Abstract: A measurement device includes a measurement head configured to capture dimensional measurement data of a measurement object. A guide structure is configured to move and guide at least one of the measurement head and the measurement object in a measurement volume of the measurement device. A measurement unit is configured to capture positional data of the guide structure based on which a pose of the measurement head can be calculated. Multiple temperature sensor units are configured to capture temperature data about the measurement volume. Each temperature sensor unit includes a carrier element, a temperature sensor connected to the carrier element, and a heating element connected to the carrier element. A control system is configured to process the dimensional measurement data and the positional data and, based on the temperature data, correct at least one of the dimensional measurement data and the positional data.

Abstract: Devices for laser welding using welding wire have a welding head, a wire guide for the welding wire, and a wire feed drive. The welding wire can be moved by the wire feed drive during a welding process with a feed movement in a feed direction, guided by the wire guide. A positioning device has a positioning drive, by which the welding wire is moved in an oscillating manner in the longitudinal direction of the welding wire, when a wire end of the welding wire is arranged in a welding readiness position. Methods for laser welding using a welding wire as added material are carried out using the devices. A control program controls the devices. The devices for laser welding can be provided as a part of a welding robot.

Abstract: A coordinate measuring machine and a method for operating a coordinate measuring machine, and a rotary table module for a coordinate measuring machine with a rotary table for receiving a workpiece and a rotary table block are provided. The rotary table is supported on a rotary table side rotatably about a rotary table axis. The rotary table block has, opposite the rotary table side of the rotary table block, a bottom side with which the rotary table module can be supported on a measurement table of the coordinate measuring machine. The rotary table block has a further supporting side with which the rotary table block is supportable on the measurement table of the coordinate measuring machine and which differs from the bottom side in its alignment. The rotary table module includes a pose capturing device for the determination of whether the rotary table block is supported on the bottom side.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with a gene of the ATP-binding cassette (ABC) family, such as ABCA3.

Abstract: The present disclosure provides a pharmaceutical composition comprising a polyribonucleotide for use in treating a ciliopathy in a subject suffering of a ciliopathy, wherein the polyribonucleotide encodes a functional version of a protein a defect of which is associated with said ciliopathy, and wherein administration of said pharmaceutical composition to the respiratory system of said subject is effected when the subject shows an inflammation of the respiratory system. Further, the present disclosure relates to a method for analyzing the effect of a polyribonucleotide on ciliogenesis, wherein said polyribonucleotide encodes a protein involved in and/or required for ciliogenesis.

Abstract: The present disclosure provides a method of purifying mRNA molecules comprising (Ia) purifying precipitated mRNA molecules from a suspension comprising precipitated mRNA molecules, (Ib) washing and dissolving the purified precipitated mRNA molecules, (IIa) purifying the mRNA molecules using a solution comprising a chelating agent, followed by (IIb) washing the purified mRNA molecules, wherein steps (Ia) to (IIb) are performed using tangential flow filtration.

Abstract: Described is an RNA molecule comprising (a) a coding region coding for a polypeptide; and (b) upstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:1 or a sequence which shows 1 to 4 substitutions in comparison to SEQ ID NO:1 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:1; and/or (c) downstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:2 or a sequence which shows 1 to 7 substitutions in comparison to SEQ ID NO:2 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:2; wherein said polypeptide encoded by said coding region is not a cytochrome b-245 alpha polypeptide (CYBA). Moreover, described is a nucleic acid molecule encoding the RNA molecule according to the present invention.

Abstract: A coordinate measuring machine and a method for operating a coordinate measuring machine, and a rotary table module for a coordinate measuring machine with a rotary table for receiving a workpiece and a rotary table block are provided. The rotary table is supported on a rotary table side rotatably about a rotary table axis. The rotary table block has, opposite the rotary table side of the rotary table block, a bottom side with which the rotary table module can be supported on a measurement table of the coordinate measuring machine. The rotary table block has a further supporting side with which the rotary table block is supportable on the measurement table of the coordinate measuring machine and which differs from the bottom side in its alignment. The rotary table module includes a pose capturing device for the determination of whether the rotary table block is supported on the bottom side.

Abstract: In certain aspects, the disclosure relates to compositions comprising modified Ornithine transcarbamylase (OTC) polyribonucleotides and methods of use.

Abstract: The present disclosure provides polyribonucleotides, in particular polyribonucleotides, which comprise deuterated adenosine, cytidine, guanosine, and/or uridine residues and which show reduced immunogenicity and/or enhanced expression, and methods of using such polyribonucleotides for the therapy of diseases.

Abstract: In certain aspects, the disclosure relates to compositions comprising modified Ornithine transcarbamylase (OTC) polyribonucleotides and methods of use.

Abstract: Described is an RNA molecule comprising (a) a coding region coding for a polypeptide; and (b) upstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:1 or a sequence which shows 1 to 4 substitutions in comparison to SEQ ID NO:1 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:1; and/or (c) downstream of said coding region one or more UTR(s) comprising the sequence as shown in SEQ ID NO:2 or a sequence which shows 1 to 7 substitutions in comparison to SEQ ID NO:2 and which results in an RNA molecule having the same or a higher translation efficiency as an RNA molecule comprising an UTR comprising SEQ ID NO:2; wherein said polypeptide encoded by said coding region is not a cytochrome b-245 alpha polypeptide (CYBA). Moreover, described is a nucleic acid molecule encoding the RNA molecule according to the present invention.

Abstract: Devices for laser welding using welding wire have a welding head, a wire guide for the welding wire, and a wire feed drive. The welding wire can be moved by the wire feed drive during a welding process with a feed movement in a feed direction, guided by the wire guide A positioning device has a positioning drive, by which the welding wire is moved in an oscillating manner in the longitudinal direction of the welding wire, when a wire end of the welding wire is arranged in a welding readiness position. Methods for laser welding using a welding wire as added material are carried out using the aforementioned device. A control program controls the devices. The devices for laser welding can be provided as a part of a welding robot.

Abstract: A method for starting an internal combustion engine with a fuel tank and a low-pressure pump which pumps gasoline out of the fuel tank at a low-pressure to a high-pressure pump that pumps the gasoline at a high-pressure to injectors of the internal combustion engine. An electronic controller is provided for controlling and/or regulating the low-pressure pump, the high-pressure pump, and the injectors. After a start pulse for the internal combustion engine, the method: checks whether a formation of vapor bubbles in the gasoline is possible on the low-pressure side during a hot start. If not possible, then the normal low-pressure is set. If possible, then a low pressure which is high enough that the formation of vapor bubbles is not possible on the low-pressure side is set, and the normal low-pressure is set after a period of time. The problem of vapor bubble formation is prevented in an inexpensive or cost neutral manner via the method.

Abstract: Polynucleotides encoding peptides, proteins, enzymes, and functional fragments thereof are disclosed. The polynucleotides of the disclosure can be effectively delivered to an organ, such as the lung, and expressed within cells of the organ. The polyribonucleotides of the disclosure can be used to treat a disease or condition associated with a gene of the ATP-binding cassette (ABC) family, such as ABCA3.

Abstract: A method for starting an internal combustion engine with a fuel tank and a low-pressure pump which pumps gasoline out of the fuel tank at a low-pressure to a high-pressure pump that pumps the gasoline at a high-pressure to injectors of the internal combustion engine. An electronic controller is provided for controlling and/or regulating the low-pressure pump, the high-pressure pump, and the injectors. After a start pulse for the internal combustion engine, the method: checks whether a formation of vapor bubbles in the gasoline is possible on the low-pressure side during a hot start. If not possible, then the normal low-pressure is set. If possible, then a low pressure which is high enough that the formation of vapor bubbles is not possible on the low-pressure side is set, and the normal low-pressure is set after a period of time. The problem of vapor bubble formation is prevented in an inexpensive or cost neutral manner via the method.

Abstract: The invention discloses a method for expressing an mRNA in lung wherein —the mRNA to be expressed is combined with polyethyleneimine (PEI) to provide a combination comprising the mRNA and PEI; —the combination comprising the mRNA and PEI is administered to lung where it enters lung cells; and —the mRNA is expressed in the lung cells.

Abstract: A control unit has an ABS control algorithm. For use on motorcycles, it is advantageous if the control unit also includes an airbag algorithm for actuating an airbag, a maximum of two but preferably only a single acceleration sensor for detecting a collision, and a maximum of two but preferably only a single ignition stage which generates a signal for igniting an airbag when a collision is detected.