Abstract: The present invention relates to a system (10) for supporting an elderly, frail and/or diseased person (12), in particular a person suffering from Parkinson's disease, wherein the system (10) comprises: a detection unit (14) including (i) a brain activity sensor (20) for detecting a brain activity signal relating to the brain activity of the person (12) and (ii) a motion detection unit (22) for detecting a motion signal relating to a motion of one or more body parts of the person (12); an analysis unit (16) for determining, based on the detected brain activity signal and motion signal, an activity level of the person (12) which is indicative of the motoric and cognitive activity of the person (12); and a feedback unit (18) for providing a feedback to the person (12) if the activity level of the person (12) exceeds a predetermined threshold.

Abstract: According to an aspect, there is provided an apparatus (2) for use in detecting malingering by a first subject in one or more physical and/or mental function tests, the apparatus (2) comprising a memory unit (10) and a processing unit (8). The memory unit (10) is configured to store information relating to a multivariate probability distribution, MPD, for a plurality of parameters, with each parameter relating to a particular physical and/or mental function test in a set of physical and/or mental function tests, the MPD being determined from one or more population test results, and each population test result relating to the performance of one or more tests in the set by a respective subject in a population of subjects and comprising values for the parameters relating to the one or more tests performed by the subject.

Abstract: According to an aspect there is provided an apparatus for determining a measure of the physical fitness of a subject, the apparatus comprising a processing unit that is configured to receive a first measurement signal from a first sensor that measures the force or pressure exerted on an object by the subject over time, the first measurement signal comprising measurements representing the force or pressure exerted on the object during a first movement in which the subject sits down on the object and/or during a second movement in which the subject stands up after sitting on the object; and analyze the first measurement signal to determine the measure of the physical fitness of the subject.

Abstract: The present invention relates to a selective reduction of specific aldehydes and ketones to their corresponding alcohols.

Abstract: The present invention relates to a selective reduction of esters to their corresponding alcohols.

Abstract: The present invention relates to a selective reduction of esters to their corresponding alcohols.

Abstract: The present disclosure relates to a method and non-transitory machine-readable storage medium encoded with instructions for using prediction models for predicting values, the medium comprising instructions for receiving a plurality of entry identifiers, instructions for receiving a value for each of the plurality of entry identifiers, instructions for determining whether the value for each of the plurality of entry identifiers has changed and a magnitude of the change, instructions for building a model for predicting a time-to-value change;, instructions for building a model for predicting a future magnitude of change, instructions for performing a simulation using the model for predicting the time-to-value change and the model for predicting the future magnitude of change and instructions for outputting a confidence interval.

Abstract: In summary the invention relates to a stimuli control system configured for finding ambient stimuli from a database in a way so that the ambient stimuli having the most promising effect on stress reduction is selected. The selection may be performed based on a probability distribution created for describing how likely it is that a given ambient stimuli has a positive effect on the stress level for a given patient or other user. The database is a multiuser database which may be updated based on experiences from users' already registered ambient stimuli.

Abstract: The present invention relates to a system (10) for supporting an elderly, frail and/or diseased person (12), in particular a person suffering from Parkinson's disease, wherein the system (10) comprises: a detection unit (14) including (i) a brain activity sensor (20) for detecting a brain activity signal relating to the brain activity of the person (12) and (ii) a motion detection unit (22) for detecting a motion signal relating to a motion of one or more body parts of the person (12); an analysis unit (16) for determining, based on the detected brain activity signal and motion signal, an activity level of the person (12) which is indicative of the motoric and cognitive activity of the person (12); and a feedback unit (18) for providing a feedback to the person (12) if the activity level of the person (12) exceeds a predetermined threshold.

Abstract: A stress-measuring device (10) and method determines a level (15) of stress of a user (1), in particular long-term stress. The stress-measuring device (10) includes an input interface (12) for receiving a skin conductance signal (11) indicating the skin conductance of the user (1), the skin conductance signal (11) over time forming skin conductance trace data (13). The stress-measuring device (10) further includes a processing unit (14) for processing the skin conductance trace data (13). The processing unit (14) determines, over at least a portion of the skin conductance trace data (13), values of a rise time (tr) between at least two different points of the skin conductance trace data (13), a frequency distribution of the rise time (tr) values, and the level (15) of stress of the user (1) based on the determined frequency distribution.

Abstract: The present invention relates to a system for assisting a person in walking, comprising a measurement unit for measuring physiological data including vital sign data and movement data of the person; an activity ability determination unit which is configured to determine a frailty state of the person based on the vital sign data, and to determine walking characteristics of the person based on the movement data; an activity program unit which is configured to select and continuously update a walking program based on the determined frailty state of the person and the determined walking characteristics of the person.

Abstract: The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.

Abstract: The invention relates to a process for the production of 5-formylvaleric acid and adipic acid or esters thereof from an isomeric mixture of pentenoic acid or esters thereof said mixture comprising at least 4-pentenoic acid or esters thereof, and further comprising 3-pentenoic acid and/or 2-pentenoic acid or esters thereof. The process allows for efficient production of two different intermediates for producing polyamide using a single process, with good selectivity, little waste, in an economically efficient fashion. The process is very suitable to use an isomeric pentenoic acid mixture obtained from valerolactone, and can be used to produce renewable polyamide intermediates using a single process.

Abstract: The invention relates to a process for the production of 5-formylvaleric acid and adipic acid or esters thereof from an isomeric mixture of pentenoic acid or esters thereof said mixture comprising at least 4-pentenoic acid or esters thereof, and further comprising 3-pentenoic acid and/or 2-pentenoic acid or esters thereof. The process allows for efficient production of two different intermediates for producing polyamide using a single process, with good selectivity, little waste, in an economically efficient fashion. The process is very suitable to use an isomeric pentenoic acid mixture obtained from valerolactone, and can be used to produce renewable polyamide intermediates using a single process.

Abstract: A healthcare decision support system for tailoring patient care comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor causing the processor to perform the steps of obtaining media stimulation and feedback data of a patient in an adaptive healing environment, said media stimulation and feedback data including information on interactions of the patient with the adaptive healing environment, obtaining condition data of the patient, obtaining electronic health record data of the patient, evaluating the obtained data and determining a patient parameter including information on the patient set and providing the patient parameter set to a medical decision support component. The present invention further relates to a corresponding method and to a patient care system.

Abstract: A process for producing furfural and levulinic acid from lignocellulose-comprising biomass is disclosed. The biomass is slurried using water and optionally an acid, subjected to hydrolysis, and then subjected to a solid/liquid separation to yield at least an aqueous fraction comprising C5 and C6 sugars and a solid fraction comprising cellulose and lignin. Furfural is obtained by adding an organic solvent to the aqueous fraction, heating at 120-220° C. for a sufficient time to form furfural, cooling, and separating an organic phase comprising at least part of the furfural from an aqueous phase. Levulinic acid is obtained by suspending the solid fraction in water and optionally an acid, heating the suspension to 140-220° C., and separating an aqueous fraction comprising the levulinic acid from a solid fraction.

Abstract: A healthcare support system for determining care for a patient and a corresponding healthcare support method are presented. The healthcare support system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining patient data, assessing a clinical need of the patient, proposing a clinical outcome, and determining a service to be provided to the patient for said clinical need and said proposed clinical outcome based on a service-outcome-need model. Further, the present invention relates to a computer-readable non-transitory storage medium and a computer program.

Abstract: The present invention relates to a method for preparing caprolactone, comprising converting 5-hydroxymethyl-2-furfuraldehyde by hydrogenation into at least one intermediate compound selected from the group of 2,5-tetrahydrofuran-dimethanol, 1,6-hexanediol and 1,2,6-hexanetriol, and preparing caprolactone from said intermediate compound. Further, the invention relates to a method for preparing 1,2,6-hexanetriol comprising preparing 5-hydroxymethyl-2-furfaldehyde from a renewable source, converting 5-hydroxymethyl-2-furfaldehyde into 2,5-tetrahydrofuran-dimethanol and converting 2,5-tetrahydrofuran-dimethanol into 1,2,6-hexanetriol. Further, the invention relates to a method for preparing 1,6-hexanediol from 1,2,6-hexanetriol, wherein 1,2,6-hexanetriol is subjected to a ring closure reaction, thereby forming (tetrahydro-2H-pyran-2-yl)methanol, and the (tetrahydro-2H-pyran-2-yl)methanol is hydrogenated, thereby forming 1,6-hexane diol.

Abstract: The present invention relates to a healthcare system and a corresponding healthcare method. The system comprises a processor and a computer-readable storage medium, wherein the computer-readable storage medium contains instructions for execution by the processor, wherein the instructions cause the processor to perform the steps of obtaining patient activity data descriptive of a physical activity of a patient, for whom a recommendation for a care plan shall be provided, obtaining social support activity data descriptive of a level of interaction of the patient's social network with the patient, and computing recommendations for a care plan for the patient based on the patient activity data and the social support activity data. Further, the present invention relates to a computer-readable non-transitory storage medium and a computer program.

Abstract: The invention relates to the field of carbohydrate chemistry. Provided is a process for the regioselective oxidation of a single secondary hydroxy function of a carbohydrate substrate comprising two or more secondary hydroxy functions, comprising contacting the carbohydrate substrate in a solvent in the presence of a transition metal catalyst complex with an oxidizing agent to yield a mono-oxidized carbohydrate.