Patents by Inventor Johannes H. Fruehauf

Johannes H. Fruehauf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BACTERIAL MEDIATED THF ALPHA GENE SILENCING
    Publication number: 20180087060
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating an inflammatory disease or disorder. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Application
    Filed: December 9, 2017
    Publication date: March 29, 2018
    Inventors: Johannes H. Fruehauf, Chiang J. Li
  • COMPOSITIONS FOR BACTERIAL MEDIATED GENE SILENCING AND METHODS OF USING SAME
    Publication number: 20160369282
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating cancer of cell proliferative disorders. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Application
    Filed: October 6, 2015
    Publication date: December 22, 2016
    Inventors: Chiang Li, Johannes H. Fruehauf, Shuanglin Xiang
  • BACTERIAL MEDIATED THF ALPHA GENE SILENCING
    Publication number: 20150030573
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating an inflammatory disease or disorder. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Application
    Filed: October 26, 2013
    Publication date: January 29, 2015
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Johannes H. Fruehauf, Ching J. Li
  • BACTERIAL MEDIATED THF ALPHA GENE SILENCING
    Publication number: 20150017138
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating an inflammatory disease or disorder. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Application
    Filed: July 11, 2014
    Publication date: January 15, 2015
    Inventors: Johannes H. Fruehauf, Chiang J. Li
  • E. Coli Mediated Gene Silencing of Beta-Catenin
    Publication number: 20100189691
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium or BTP. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating viral diseases and disorders. The bacterium or BTP includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Application
    Filed: November 13, 2009
    Publication date: July 29, 2010
    Applicant: Cequent Pharmaceuticals, Inc.
    Inventors: Johannes H. Fruehauf, Moreswhar B. Vaze, Floyd S. Laroux, Jessica A. Sexton