Abstract: The invention concerns a phenoxyphenyl compound having the formula ##STR1## wherein R is one or two halogen atoms; andA is CH.sub.2 NR.sub.1 R.sub.2 or 4,5-dihydro-1H-imidazole, in which R.sub.1 and R.sub.2 are independently selected from hydrogen and lower alkyl; ora pharmaceutically acceptable salt thereof.The compounds have long half-lives and can be used against depression.

Abstract: The invention relates to a piperazine derivative having the formula ##STR1## wherein each .phi. is a phenyl group which may independently be substituted by one or more substituents selected from the group consisting of lower alkyl, lower alkoxy, CF.sub.3, and halogen, and Y is O or S, or a pharmaceutically acceptable salt thereof. The piperazine derivatives have sigma receptor affinity, and may be used for the treatment of psychosis.

Abstract: The invention relates to a 3-quinuclidine derivative having the formula I ##STR1## wherein X is O or S, and R represents one to five substituents independently selected from hydrogen, hydroxy, lower alkyl, lower alkoxy, lower aralkyloxy, lower alkanoyloxy, halogen, NO.sub.2, CF.sub.3, CN, NR.sub.1 R.sub.2, and COR.sub.3, in which R.sub.1 and R.sub.2 are independently selected from hydrogen, lower alkyl, and lower alkanoyl, and R.sub.3 is selected from OH, lower alkyl, lower alkoxy, and NR.sub.4 R.sub.5, wherein R.sub.4 and R.sub.5 are independently hydrogen or lower alkyl; or pharmaceutically acceptable salts thereof.

Abstract: The invention concerns a phenoxyphenyl derivative having the formula ##STR1## wherein R is one or two halogen atoms; andA is CH.sub.2 NR.sub.1 R.sub.2 or 4,5-dihydro-1H-imidazole, in which R.sub.1 and R.sub.2 are independently selected from hydrogen and lower alkyl; ora pharmaceutically acceptable salt thereof.The compounds have long half-lives and can be used against depression.

Abstract: Dibenzodioxazecine and dibenzodioxaazacycloundecine derivatives having the general formula I: ##STR1## or a pharmaceutically acceptable salt or nitrogen oxide thereof, in which R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each represent independently hydrogen, hydroxy, halogen, cyano, alkyl, alkoxy or CF.sub.3 ;R.sub.5 represents hydrogen, alkyl, alkenyl, aralkyl, hydroxyalkyl or acyloxyalkyl; andn represents the number 1 or 2.The compounds in accordance with the invention are valuable C.N.S. (central nervous systems) active compounds, and in particular possess strong anti-psychotic properties with low propensity to induce extra-pyramidal side effects.

Abstract: This invention relates to dopamine uptake-inhibiting compounds of the general formula I: ##STR1## wherein R.sup.1 and R.sup.2 independently are hydrogen, NO.sub.2, OH, halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, unsubstituted amino or C.sub.1 -C.sub.4 alkyl substituted amino;X denotes O, S, CH.sub.2, NH or NALK;A represents C.sub.m H hd 2m or C.sub.k H.sub.2k O;l is 1 to 4;m is 0 to 2;n is 0 to 1;Q represents hydrogen, phenyl or an ALK group optionally substituted by phenyl, whereinALK is a C.sub.1 -C.sub.6 aliphatic hydrocarbon;and the acid addition salts thereof.

Abstract: The invention relates to novel tetracyclic compounds with an anti-depressant action, without neuroleptic or sedative side effects, of the general formula I ##STR1## and also functional derivatives hereof, wherein: R.sup.1 represents one or two identical or different substituents denoting H, OH, halogen, C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.4 alkoxy;R.sup.2 represents one or two identical or different substituents having the same meaning as R.sup.1 ;R.sup.3 and R.sup.4 are two substituents which are in the cis configuration and of which one is H and the other is OH;R.sup.5 is H or C.sub.1 -C.sub.4 alkyl;X denotes O or S;n is 0 or 1.

Abstract: The present invention relates to new tricyclic compounds of the formula: ##STR1## having valuable CNS and cardiovascular properties.

Abstract: The present invention relates to new dibenzoxazonine, dibenz-oxazecine or dibenzo-oxaazacycloundecane derivatives and corresponding thia- and aza derivatives thereof, of the general formula I: ##STR1## or a pharmaceutically acceptable acid addition salt or nitrogen oxide thereof, in whichX represents oxygen, sulphur or the group NR.sub.5,R.sub.5 is hydrogen or alkyl (1-4 C),R.sub.1, R.sub.2, R.sub.3, R.sub.4 each represent hydrogen, hydroxy, halogen, cyano, alkyl, alkoxy, aralkoxy, alkylthio, methylenedioxy, CF.sub.3, NO.sub.2, NH.sub.2, hydroxyalkyl or an acyloxy group,R represents hydrogen, alkyl, alkenyl or aralkyl, hydroxyalkyl or acyloxyalkyl andn represents the number 0, 1 or 2, having valuable C.N.S. properties.