Patents by Inventor Johannes Heinrich. Fruehauf

Johannes Heinrich. Fruehauf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for Bacterial Mediated Gene Silencing and Methods of Using Same
    Publication number: 20120093773
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating cancer of cell proliferative disorders. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Application
    Filed: August 2, 2011
    Publication date: April 19, 2012
    Inventors: Chiang Li, Johannes Heinrich Fruehauf, Shuanglin Xiang
  • BACTERIAL MEDIATED TNF ALPHA GENE SILENCING
    Publication number: 20100239546
    Abstract: Methods are described for the delivery of one or more small interfering RNAs (siRNAs) to a eukaryotic cell using a bacterium. Methods are also described for using this bacterium to regulate gene expression in eukaryotic cells using RNA interference, and methods for treating an inflammatory disease or disorder. The bacterium includes one or more siRNAs or one or more DNA molecules encoding one or more siRNAs. Vectors are also described for use with the bacteria of the invention for causing RNA interference in eukaryotic cells.
    Type: Application
    Filed: June 13, 2008
    Publication date: September 23, 2010
    Applicant: BETH ISRAEL DEACONESS MEDICAL CENTER
    Inventors: Johannes Heinrich. Fruehauf, Chiang Li