Patents by Inventor Johannes Hendrikus Nicolaas Lindeman

Johannes Hendrikus Nicolaas Lindeman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the functional determination of mannan-binding-lectin associated serine proteases (MASPs) and complexes thereof
    Patent number: 7811771
    Abstract: This invention relates to the field of determining, assaying or quantifying activity of components of the complement system. More particularly, the invention relates to methods for detecting the presence or level of activity in a sample of mannan-binding-lectin associated serine proteases (MASPs) or complexes of such proteases with lectins and to detection of the particular lectins themselves. Provided is a method for determining the activity of a MASP in a sample, comprising incubating the sample with a pro-urokinase comprising at its activation site the consensus sequence Arg/Leu/Gly-Yyy-Arg/Lys-Ile/Leu/Val-Zzz-Gly-Gly cleavable by a MASP, wherein Yyy can be any amino acid and Zzz is preferably an aliphatic amino acid, and determining proteolytic activation of said pro-urokinase.
    Type: Grant
    Filed: December 19, 2005
    Date of Patent: October 12, 2010
    Assignee: Nederlandse Organisatie voor toegepast-natuurwetenschappelijk Onderzoek TNO
    Inventors: Johan Hendrikus Verheijen, Jan Roeland Occo Hanemaaijer, Natascha Alexandra Van Lent, Johannes Hendrikus Nicolaas Lindeman, Mohamed Rahoef Daha, Johanna Roos
  • Method for the Functional Determination of Mannan-Binding-Lectin Associated Serine Proteases (Masps) and Complexes Thereof
    Publication number: 20080286803
    Abstract: This invention relates to the field of determining, assaying or quantifying activity of components of the complement system. More particularly, the invention relates to methods for detecting the presence or level of activity in a sample of mannan-binding-lectin associated serine proteases (MASPs) or complexes of such proteases with lectins and to detection of the particular lectins themselves. Provided is a method for determining the activity of a MASP in a sample, comprising incubating the sample with a pro-urokinase comprising at its activation site the consensus sequence Arg/Leu/Gly-Yyy-Arg/Lys-Ile/Leu/Val-Zzz-Gly-Gly cleavable by a MASP, wherein Yyy can be any amino acid and Zzz is preferably an aliphatic amino acid, and determining proteolytic activation of said pro-urokinase.
    Type: Application
    Filed: December 19, 2005
    Publication date: November 20, 2008
    Inventors: Johan Hendrikus Verheijen, Jan Roeland Occo Hanemaaijer, Natascha Alexandra Van Lent, Johannes Hendrikus Nicolaas Lindeman, Mohamed Rahoef Daha, Johanna Roos