Patents by Inventor Johannes Hendrikus van Es

Johannes Hendrikus van Es has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment of an intestinal adenoma and/or adenocarcinoma by inhibition of notch pathway activation
    Publication number: 20100292165
    Abstract: The invention relates to the field of biochemistry and medicine. More specifically, the invention relates to methods and pharmaceuticals for the treatment of intestinal neoplasia. The invention discloses the surprising finding that inhibitors of Notch pathway activation (for example, ?-secretase inhibitors) are extremely useful in the treatment of intestinal adenoma and/or adenocarcinoma.
    Type: Application
    Filed: July 26, 2010
    Publication date: November 18, 2010
    Applicant: Hubrecht Laboratorium a corporation of the Netherlands
    Inventors: Johannes Carolus Clevers, Maria Elisabeth Van Gijn, Johannes Hendrikus Van Es
  • Treatment of Barrett's Esophagus
    Publication number: 20090306049
    Abstract: The invention relates to the field of biochemistry and medicine. More specifically, the invention relates to the treatment of epithelial changes in the esophagus. Even more specific, the invention relates to the treatment of Barrett's esophagus. The invention provides a method for at least in part decreasing Barrett's esophagus present in an animal comprising at least in part inhibiting Notch pathway activation in said animal. Preferably, said inhibition of Notch pathway activation is accomplished via a g-secretase inhibitor.
    Type: Application
    Filed: December 8, 2006
    Publication date: December 10, 2009
    Applicant: HUBRECHT LABORATORIUM
    Inventors: Johannes Carolus Clevers, Johannes Hendrikus van Es