Patents by Inventor Johannes Hildebrandt

Johannes Hildebrandt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10571292
    Abstract: Embodiments of the present disclosure relate to a method and a system for determining a route from a motor vehicle location to a destination, in which a vehicle control unit transmits an emergency call to a recipient of a central exchange. In the process, a computing device at the central exchange determines the route to the destination. In the process, the computing device of the central exchange takes into account, in selecting the destination, a first time period which the motor vehicle requires to traverse the route and a second time period which a rescue vehicle requires to reach the destination. The computing device selects the destination such that a sum of the two time periods is minimal.
    Type: Grant
    Filed: April 26, 2017
    Date of Patent: February 25, 2020
    Assignee: AUDI AG
    Inventors: Christian Schmell, Johannes Kniep, G√ľnter Hildebrandt, Christoph Weigand, Florian Schwensfeier
  • Patent number: 7790749
    Abstract: A method of preventing or treating diseases mediated by Helicobacter pylori, comprising administering to a subject in need of such treatment an effective amount of pleuromutilin.
    Type: Grant
    Filed: April 22, 2003
    Date of Patent: September 7, 2010
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Johannes Hildebrandt
  • Publication number: 20090209584
    Abstract: A compound of formula (I) wherein R and R2 and the attached nitrogen atom form pyrrolidinyl or piperidinyl. R1 is a group of formula (II). R3 and R?3 are hydrogen, deuterium or halogen. R4, R5 and R10 are independently of each other hydrogen or alkyl. R6, R7 and R8 are hydrogen or deuterium. R9 is amino, alkyl, aryl, heterocyclyl or mercapto. If X is oxygen, R9 is additionally hydrogen; R?10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0, 1 or 2, with the proviso that, when R and R2 and the attached nitrogen atom form piperidinyl, m is O, Y is S and Y is attached in position 3 of the piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S)-configuration which is useful as antimicrobial, antibacterial.
    Type: Application
    Filed: April 7, 2009
    Publication date: August 20, 2009
    Applicant: Nabriva Therapeutics Forschungs AG
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 7569587
    Abstract: A compound of formula (I) wherein R and R2 and the attached nitrogen atom form pyrrolidinyl or piperidinyl. R1 is a group of formula (II). R3 and R?3 are hydrogen, deuterium or halogen. R4, R5 and R10 are independently of each other hydrogen or alkyl. R6, R7 and R8 are hydrogen or deuterium. R9 is amino, alkyl, aryl, heterocyclyl or mercapto. If X is oxygen, R9 is additionally hydrogen; R?10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0,1 or 2, with the proviso that, when R and R2 and the attached nitrogen atom form piperidinyl, m is O, Y is S and Y is attached in position 3 of the piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S)-configuration which is useful as antimicrobial, antibacterial.
    Type: Grant
    Filed: January 12, 2007
    Date of Patent: August 4, 2009
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 7534814
    Abstract: A compound of formula wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.
    Type: Grant
    Filed: June 14, 2004
    Date of Patent: May 19, 2009
    Assignee: Nabriva Therapeutics AG
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Publication number: 20070135483
    Abstract: A compound of formula (I) wherein R and R2 together with the nitrogen atom to which they are attached form pyrrolidinyl or piperidinyl, R1 is a group of formula (II) R3 and R?3 are hydrogen, deuterium or halogen, R4, R5 and R10 are independently of each other hydrogen or alkyl, R6, R7 and R8 are hydrogen or deuterium; R9 is amino, alkyl, aryl, heterocyclyl or mercapto; and, if X is oxygen, R9 is additionally hydrogen; R10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0,1 or 2; with the proviso that, when R and R2 together with the nitrogen atom to which they are attached form piperidinyl, m is O, Y is S and Y is attached in position 3 of said piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-conflguration, preferably in the (S)-configuration which is e.g. useful as antimicrobial, antibacterial.
    Type: Application
    Filed: January 12, 2007
    Publication date: June 14, 2007
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Publication number: 20070117764
    Abstract: Highly compatible or synergistic combinations of a macrolide T-cell immunomodulator or immunosuppressant such as 33-epichloro-33-desoxyascomycin and an antibacterial such as sulfasalazin, ciprofloxacin, ofloxacin, erythromycin or gentamycin, optionally with a further pharmaceutically active agent, especially a retinoid, are provided, which are useful in particular in the treatment of diseases involving bacterial or suspected or anticipated bacterial infection, for immunomodulation or immunosuppression in conditions in which bacterial or suspected or anticipated bacterial colonization of e.g. the skin plays a role, such as atopic, contact and seborrhoeic dermatitis, eczema, psoriasis, acne, rosacea, post-peel, skin burning, itching, or IBD, and in situations of bacterial resistance.
    Type: Application
    Filed: April 2, 2004
    Publication date: May 24, 2007
    Inventors: Maximilian Grassberger, Johannes Hildebrandt, Stefan Hirsch, Carle Paul, Neil Ryder, Nabila Sekkat, Anton Stutz
  • Patent number: 7169804
    Abstract: A compound of formula (I) wherein R and R2 together with the nitrogen atom to which they are attached form pyrrolidinyl or piperidinyl, R1 is a group of formula (II) R3 and R?3 are hydrogen, deuterium or halogen, R4, R5 and R10 are independently of each other hydrogen or alkyl, R6, R7 and R8 are hydrogen or deuterium; R9 is amino, alkyl, aryl, heterocyclyl or mercapto; and, if X is oxygen, R9 is additionally hydrogen; R?10 is alkyl, X is sulphur, oxygen, NR10, or N+(R?10)2; Y is sulphur or oxygen, and m is 0, 1 or 2; with the proviso that, when R and R2 together with the nitrogen atom to which they are attached form piperidinyl, m is O, Y is S and Y is attached in position 3 of said piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S) -configuration which is e.g. useful as antimicrobial, antibacterial.
    Type: Grant
    Filed: September 11, 2001
    Date of Patent: January 30, 2007
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Publication number: 20050131023
    Abstract: A method of preventing or treating diseases mediated by Helicobacter pylori, comprising administering to a subject in need of such treatment an effective amount of pleuromutilin.
    Type: Application
    Filed: April 22, 2003
    Publication date: June 16, 2005
    Inventors: Gerd Ascher, Johannes Hildebrandt
  • Publication number: 20040235910
    Abstract: A compound of formula 1
    Type: Application
    Filed: June 14, 2004
    Publication date: November 25, 2004
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 6784193
    Abstract: A compound of formula (I) wherein R2 is arylene or heterocyclene; or R and R2 together with the nitrogen atom to which they are attached form non-aromatic heterocyclene; and the other residues have various meanings, useful as pharmaceuticals, e.g. antimicrobials.
    Type: Grant
    Filed: January 28, 2002
    Date of Patent: August 31, 2004
    Assignee: Sandoz GmbH
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Publication number: 20040132709
    Abstract: A compound of formula 1
    Type: Application
    Filed: November 12, 2003
    Publication date: July 8, 2004
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Publication number: 20040102482
    Abstract: A compound of formula (I) wherein R and R2 together with the nitrogen atom to which they are attached form pyrrolidinyl or piperidinyl, R1 is a group of formula (II) R3 and R′3 are hydrogen, deuterium or halogen, R4, R5 and R10 are independently of each other hydrogen or alkyl, R6, R7 and R8 are hydrogen or deuterium; R9 is amino, alkyl, aryl, heterocyclyl or mercapto; and, if X is oxygen, R9 is additionally hydrogen; R′10 is alkyl, X is sulphur, oxygen, NR10, or N+(R′10)2; Y is sulphur or oxygen, and m is 0, 1 or 2; with the proviso that, when R and R2 together with the nitrogen atom to which they are attached form piperidinyl, m is O, Y is S and Y is attached in position 3 of said piperidine ring, that group of formula (I) which is attached to the piperidine ring via the residue Y is either in the (S)-configuration or in the (R)-configuration, preferably in the (S) -configuration which is e.g. useful as antimicrobial, antibacterial.
    Type: Application
    Filed: March 10, 2003
    Publication date: May 27, 2004
    Inventors: Gerd Ascher, Heinz Berner, Johannes Hildebrandt
  • Patent number: 6693095
    Abstract: A compound of formula wherein W, V, R1, R5, R2, R3 and R4 have various meanings, a process for their production and their use as a pharmaceutical.
    Type: Grant
    Filed: November 13, 2001
    Date of Patent: February 17, 2004
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Publication number: 20030114665
    Abstract: A compound of formula 1
    Type: Application
    Filed: September 23, 2002
    Publication date: June 19, 2003
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Patent number: 6440957
    Abstract: A compound useful as an anti-bacterial agent, having the formula wherein R2 together with the nitrogen atom to which it is attached forms a cyclic aminoguanidine group or derivative thereof as defined
    Type: Grant
    Filed: September 21, 2000
    Date of Patent: August 27, 2002
    Assignee: Biochemie Gesellschaft m.b.H.
    Inventors: Gerd Ascher, Werner Heilmayer, Johannes Ludescher, Johannes Hildebrandt, Michael Schranz, Josef Wieser
  • Publication number: 20020115852
    Abstract: A compound of formula 1
    Type: Application
    Filed: November 13, 2001
    Publication date: August 22, 2002
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Publication number: 20020091252
    Abstract: A compound of formula 1
    Type: Application
    Filed: November 13, 2001
    Publication date: July 11, 2002
    Inventors: Gerd Ascher, Josef Wieser, Michael Schranz, Johannes Ludescher, Johannes Hildebrandt
  • Patent number: 4428953
    Abstract: Novel pleuromutilin derivatives of formula I, ##STR1## in which R.sub.1 is ethyl or vinyl,m is 0 or 1, andR.sub.2 is a heterocyclic radical, in which a 5- or 6-membered, unsaturated or saturated heterocyclic ring containing one or more hetero atoms selected from oxygen, sulphur and nitrogen, is attached to the --S(CH.sub.2).sub.m --group,provided that when m is 0, R.sub.2 is other than pyridyl,their production and use as antimicrobial agents are described.
    Type: Grant
    Filed: March 8, 1982
    Date of Patent: January 31, 1984
    Assignee: Sandoz, Ltd.
    Inventors: Heinz Berner, Friederike Turnowsky, Georg Laber, Johannes Hildebrandt