Patents by Inventor Johannes Hubner

Johannes Hubner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11278609
    Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: March 22, 2022
    Assignees: KLINIKUM DER UNIVERSITÄT MÜNCHEN, UNIVERSITE DE CAEN BASSE-NORMANDIE
    Inventors: Johannes Hübner, Axel Hartke, Luis Felipe Romero Saavedra
  • Patent number: 11267841
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Grant
    Filed: October 7, 2019
    Date of Patent: March 8, 2022
    Assignee: KLINIKUM DER UNIVERSITÄT MÜNCHEN
    Inventors: Johannes Hübner, Otto Holst, Christian Theilacker, Zbigniew Kaczynski
  • Publication number: 20200048296
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Application
    Filed: October 7, 2019
    Publication date: February 13, 2020
    Inventors: JOHANNES HÜBNER, OTTO HOLST, CHRISTIAN THEILACKER, ZBIGNIEW KACZYNSKI
  • Patent number: 10100103
    Abstract: The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: October 16, 2018
    Assignee: ALBERT-LUDWIGS-UNIVERSITÄT FREIBURG
    Inventors: Johannes Hübner, Friederike Rossmann, Andrea Kropec Hübner
  • Publication number: 20180009834
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Application
    Filed: August 31, 2017
    Publication date: January 11, 2018
    Inventors: Johannes HÜBNER, Otto HOLST, Christian THEILACKER, Zbigniew KACZYNSKI
  • Patent number: 9796744
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Grant
    Filed: November 13, 2007
    Date of Patent: October 24, 2017
    Assignee: UNIVERSITÄTSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Otto Holst, Christian Theilacker, Zbigniew Kaczynski
  • Publication number: 20170087239
    Abstract: Medicament for the treatment or the prevention of a bacterial infection, characterized in that it contains at least one polypeptide selected from the group of SEQ ID NO: 1 to SEQ ID NO: 9, and contiguous fragments thereof, wherein said at least one polypeptide or contiguous fragment thereof induces opsonic antibodies in a patient in need thereof. The polypeptides or the contiguous fragments thereof according to the present invention can be used for the preparation of a vaccine against an infection against Enterococcus.
    Type: Application
    Filed: February 25, 2015
    Publication date: March 30, 2017
    Inventors: Johannes HÜBNER, Axel HARTKE, Felipe ROMERO
  • Publication number: 20160318997
    Abstract: The present invention in the fields of immunology and infectious diseases relates to opsonic and protective antibodies that are specific for Gram-positive bacteria, particularly to carbohydrate structures exposed on the surface of the bacteria. The invention includes monoclonal and chimeric antibodies, as well as fragments, regions and derivatives thereof. This invention also relates to the epitope to which the antibodies of the invention bind as well as the sequences, fragments, and regions of the epitopes. Both the antibodies and peptides that encompass the epitope, and regions and fragments thereof, may be used for diagnostic, prophylactic and therapeutic applications.
    Type: Application
    Filed: November 17, 2014
    Publication date: November 3, 2016
    Inventors: Johannes HÜBNER, Friederike ROSSMANN, Andrea KROPEC HÜBNER
  • Patent number: 9255157
    Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: February 9, 2016
    Assignees: Universitaetsklinikum Freiburg, Forschungszentrum Borstel
    Inventors: Johannes Hübner, Christian Theilacker, Zbigniew Kaczynski, Otto Holst
  • Patent number: 9005622
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: April 14, 2015
    Assignees: Forschungszentrum Borstel, Universitätsklinikum Freiburg
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Publication number: 20140161792
    Abstract: The present invention relates to a rhamno-polysaccharide antigen from Enterococcus faecium clonal complex which is useful as a vaccine component for therapy and/or prophylaxis of bacterial infection.
    Type: Application
    Filed: May 25, 2012
    Publication date: June 12, 2014
    Applicants: FORSCHUNGSZENTRUM BORSTEL, UNIVERSIT TSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Christian Theilacker, Zbignew Kacynski, Otto Holst
  • Publication number: 20130309264
    Abstract: The present invention relates to antigens, more particularly protein antigens of enterococcal pathogens which are useful as vaccine components for therapy and/or prophylaxis.
    Type: Application
    Filed: November 3, 2011
    Publication date: November 21, 2013
    Applicant: UNIVERSITÄTSKLINIKUM FREIBURG
    Inventors: Johannes Hübner, Elisabeth Grohmann, Andrea Kropec-Hübner
  • Publication number: 20120282268
    Abstract: The present invention relates to enterococcal cell wall components and their uses in the prevention and therapy of bacterial infection.
    Type: Application
    Filed: January 19, 2010
    Publication date: November 8, 2012
    Inventors: Johannes Hübner, Christian Theilacker, Otto Holst, Zbigniew Kaczynski
  • Patent number: 7877095
    Abstract: A method of adapting a radio network model to conditions of a real radio network consists of the following steps: defining different measuring positions; carrying out measurements of variables at the different measuring positions, thereby generating measured data; providing position-dependent modelling values, using the measured data for the modelling values from the real radio network obtained at the measuring positions; setting a fine grid in a radio cell, defining small area portions, wherein one or more of the modelling values is attributed to each area portion by the radio network model. Mathematical operations are then established for modifying the modelling values of all area portions of the fine grid by adapting the modelling values to the measured data. In this manner, the mathematical operations are for each area portion and directly dependent on the measured data and the position of the respective area portions.
    Type: Grant
    Filed: July 14, 2006
    Date of Patent: January 25, 2011
    Assignee: Actix GmbH
    Inventors: Johannes Hübner, Dietrich Hunold
  • Patent number: 7768968
    Abstract: A method of optimising real cellular, wireless communication networks comprising the steps of providing location-referenced values of subscriber traffic for area elements; transmitting a reference signal of constant transmission power; providing a cell-referenced value of the power received from the reference signal; providing a model of the communication network having an original model network configuration, and iteratively optimising the model network configuration by accumulating and weighting the subscriber traffic values of the area elements and by locally adjusting the model network configuration, to provide an optimised model network configuration.
    Type: Grant
    Filed: May 6, 2005
    Date of Patent: August 3, 2010
    Assignee: Vodafone Holding GmbH
    Inventors: Jürgen Plehn, Jann Erik Dietert, Johannes Hübner, Michael Berg, Peter Schneider, Dietrich Hunold, Peter Steinkönig, Jürgen Deiβner, Jens Voigt
  • Publication number: 20100055112
    Abstract: The present invention generally relates to the field of detecting and preventing infectious diseases caused by Enterococcus faecalis and/or Enterococcus faecium.
    Type: Application
    Filed: November 13, 2007
    Publication date: March 4, 2010
    Inventors: Johannes Hübner, Otto Holst, Christian Theilacker, Zbigniew Kaczynski
  • Publication number: 20070010204
    Abstract: A method of adapting a radio network model to conditions of a real radio network consists of the following steps: defining different measuring positions; carrying out measurements of variables at the different measuring positions, thereby generating measured data; providing position-dependent modelling values, using the measured data for the modelling values from the real radio network obtained at the measuring positions; setting a fine grid in a radio cell, defining small area portions, wherein one or more of the modelling values is attributed to each area portion by the radio network model. Mathematical operations are then established for modifying the modelling values of all area portions of the fine grid by adapting the modelling values to the measured data. In this manner, the mathematical operations are for each area portion and directly dependent on the measured data and the position of the respective area portions.
    Type: Application
    Filed: July 14, 2006
    Publication date: January 11, 2007
    Inventors: Johannes Hubner, Dietrich Hunold
  • Publication number: 20050254455
    Abstract: A method of optimising real cellular, wireless communication networks comprising the steps of providing location-referenced values of subscriber traffic for area elements; transmitting a reference signal of constant transmission power; providing a cell-referenced value of the power received from the reference signal; providing a model of the communication network having an original model network configuration, and iteratively optimising the model network configuration by accumulating and weighting the subscriber traffic values of the area elements and by locally adjusting the model network configuration, to provide an optimised model network configuration.
    Type: Application
    Filed: May 6, 2005
    Publication date: November 17, 2005
    Inventors: Jurgen Plehn, Jann Dietert, Johannes Hubner, Michael Berg, Peter Schneider, Dietrich Hunold, Peter Steinkonig, Jurgen Deissner, Jens Voigt