Patents by Inventor Johannes Jakobus Grote

Johannes Jakobus Grote has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ANTIMICROBIAL PEPTIDES DERIVED FROM CAP18
    Publication number: 20110053835
    Abstract: The present invention relates to a group of peptidic compounds which have antimicrobial activity. The compounds also have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. The compounds can be used to manufacture medicaments useful for the treatment of bacterial or fungal infections. The medicaments may be administered systemically or locally.
    Type: Application
    Filed: September 14, 2010
    Publication date: March 3, 2011
    Applicant: OctoPlus Sciences B.V.
    Inventors: Johannes Jakobus GROTE, Jan Wouter Drijfhout, Pieter Sicco Hiemstra, Marcel Jan Vonk, Maartje Johanna Nell, Guido Vincent Bloemberg
  • Peptide inhibitors of toxins derived from LL-37
    Patent number: 7807617
    Abstract: The invention relates to a peptidic compound with affinity to bacterial and fungal toxins, especially to lipopolysaccharide or lipoteichoic acid. The peptidic compound includes an amino acid sequence X1KEFX2RIVX3RIKX4FLRX5LVX6, wherein X1 represents the N-terminal part: X2 is K or E; X3 is Q or E; X4 is D or R; X5 is N or E; X6 represents the C-terminal part: an amino acid of the core sequence is optionally derivatized; the N-terminal part is acetylated, and/or the C-terminal part is amidated, and/or the sequence differs from the native amino acid sequence X1KEFKRIVQRIKDFLRNLVX6.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: October 5, 2010
    Assignee: Academisch Ziekenhuis Leiden
    Inventors: Johannes Jakobus Grote, Jan Wouter Drijfhout
  • Antimicrobial peptides derived from CAP18
    Patent number: 7803756
    Abstract: The invention provides methods to exert antimicrobial effects in prophylactic or therapeutic treatment of bacterial or fungal infections employing polypeptides that have affinity to microbial and fungal toxins.
    Type: Grant
    Filed: July 26, 2005
    Date of Patent: September 28, 2010
    Assignees: Octoplus Technologies B.V., Academisch Ziekenhuis Leiden
    Inventors: Johannes Jakobus Grote, Jan Wouter Drijfhout, Pieter Sicco Hiemstra, Marcel Jan Vonk, Maartje Johanna Nell, Guido Vincent Bloemberg
  • Antimicrobial Peptides Derived From Cap18
    Publication number: 20080249022
    Abstract: The present invention relates to a group of peptidic compounds which have antimicrobial activity. The compounds also have affinity for toxins and especially for bacterial toxins, such as lipopolysaccharide or lipoteichoic acid. The compounds can be used to manufacture medicaments useful for the treatment of bacterial or fungal infections. The medicaments may be administered systemically or locally.
    Type: Application
    Filed: July 26, 2005
    Publication date: October 9, 2008
    Applicants: OCTOPLUS TECHNOLOGIES B.V., ACADEMISCH ZIEKENHUIS LEIDEN
    Inventors: Johannes Jakobus Grote, Jan Wouter Drijfhout, Pieter Sicco Hiemstra, Marcel Jan Vonk, Maartje Johanna Nell, Guido Vincent Bloemberg