Patents by Inventor Johannes Köbberling
Johannes Köbberling has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230141809Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: December 9, 2022Publication date: May 11, 2023Inventors: Walter HUEBSCH, Nils GRIEBENOW, Hans-Georg SCHWARZ, Daniel KULKE, Claudia BOEHM, Kirsten BOERNGEN, Bernd ALIG, Wei ZHUANG, Iring HEISLER, Thomas ILG, Johannes KOEBBERLING, Adeline KOEHLER, Niels LINDNER, Ulrich GOERGENS, Claudia WELZ, Maike HINK
-
Publication number: 20230125394Abstract: The present invention relates to lysobactin for use in the treatment of bovine mastitis.Type: ApplicationFiled: June 6, 2022Publication date: April 27, 2023Inventors: Guido SCHIFFER, Stefan FALKER, Gert DAUBE, Kristine FRAATZ, Wolfgang WIEHL, Johannes KOEBBERLING
-
Patent number: 11572357Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: May 7, 2019Date of Patent: February 7, 2023Assignee: Bayer Animal Health GmbHInventors: Walter Hübsch, Nils Griebenow, Hans-Georg Schwarz, Daniel Kulke, Claudia Böhm, Kirsten Börngen, Bernd Alig, Wei Zhuang, Iring Heisler, Thomas Ilg, Johannes Köbberling, Adeline Köhler, Niels Lindner, Ulrich Görgens, Claudia Welz, Maike Hink
-
Publication number: 20220387608Abstract: The invention relates to stabilized Adrenomedullin derivatives and use thereof. In particular, the invention relates to novel, biologically active, stabilized Adrenomedullin (ADM) compounds. The invention further relates to the compounds for use in a method for the treatment and/or prevention of diseases, especially of cardiovascular, edematous and/or inflammatory disorders, and to medicaments comprising the compounds for treatment and/or prevention of cardiovascular, edematous and/or inflammatory disorders.Type: ApplicationFiled: June 12, 2020Publication date: December 8, 2022Applicant: Bayer AktiengesellschaftInventors: Johannes KÖBBERLING, Donald BIERER, Ingo FLAMME, Bernd RIEDL, Lucas Hudson HOFMEISTER, Annette BECK-SICKINGER, Sylvia ELS-HEINDL, Jan-Patrick FISCHER, Eva-Maria JÜLKE
-
Patent number: 11505545Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: October 30, 2020Date of Patent: November 22, 2022Assignee: Bayer Animal Health GmbHInventors: Walter Hübsch, Johannes Köbberling, Adeline Köhler, Hans-Georg Schwarz, Daniel Kulke, Claudia Welz, Thomas Ilg, Kirsten Börngen, Wei Zhuang, Nils Griebnow, Claudia Böhm, Niels Lindner, Maike Hink, Ulrich Görgens
-
Publication number: 20220000969Abstract: The present invention relates to the combination of lysobactin with an aminoglycoside antibiotic for use in the treatment of diseases caused by Gram-positive and Gram-negative bacteria in non-human animals. The invention proved to be particularly useful relating to the treatment of mastitis in non-human animals. Particularly bovine mastitis can be well addressed by the present invention.Type: ApplicationFiled: September 3, 2021Publication date: January 6, 2022Inventors: Guido SCHIFFER, Stefan FALKER, Gert DAUBE, Wolfgang WIEHL, Johannes KOEBBERLING
-
Patent number: 11130768Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 23, 2018Date of Patent: September 28, 2021Assignee: Bayer Animal Health GmbHInventors: Nils Griebenow, Wei Zhuang, Daniel Kulke, Adeline Köhler, Thomas Ilg, Claudia Welz, Hans-Georg Schwarz, Ulrich Görgens, Walter Hübsch, Johannes Köbberling
-
Publication number: 20210139468Abstract: The present invention covers new quinoline compounds of general formula (I), in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: May 7, 2019Publication date: May 13, 2021Inventors: Walter HÜBSCH, Nils GRIEBENOW, Hans-Georg SCHWARZ, Daniel KULKE, Claudia BÖHM, Kirsten BÖRNGEN, Bernd ALIG, Wei ZHUANG, Iring HEISLER, Thomas ILG, Johannes KÖBBERLING, Adeline KÖHLER, Niels LINDNER, Ulrich GÖRGENS, Claudia WELZ, Maike HINK
-
Publication number: 20210130315Abstract: The present invention relates to a method for the synthesis of cyclic depsipeptides, in particular emodepside, from the open form.Type: ApplicationFiled: November 6, 2018Publication date: May 6, 2021Applicants: Bayer Animal Health GmbH, THE KITASATO INSTITUTEInventors: Dirk HEIMBACH, Satoshi OMURA, Toshiaki SUNAZUKA, Tomoyasu HIROSE, Yoshihiko NOGUCHI, Johannes KÖBBERLING, Zhijie WU, Shuibiao FU, Wei WU, Jinfeng QIU, Liu HE, Xudong WEI
-
Publication number: 20210115026Abstract: The present invention covers new quinoline compounds of general formula (I): in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: October 30, 2020Publication date: April 22, 2021Inventors: Walter HÜBSCH, Johannes KÖBBERLING, Adeline KÖHLER, Hans-Georg SCHWARZ, Daniel KULKE, Claudia WELZ, Thomas ILG, Kirsten BÖRNGEN, Wei ZHUANG, Nils GRIEBNOW, Claudia BÖHM, Niels LINDNER, Maike HINK, Ulrich GÖRGENS
-
Patent number: 10889573Abstract: The present invention covers new quinoline compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: November 6, 2017Date of Patent: January 12, 2021Assignee: Bayer Animal Health GMBHInventors: Walter Hübsch, Johannes Köbberling, Adeline Köhler, Hans-Georg Schwarz, Daniel Kulke, Claudia Welz, Thomas Ilg, Kirsten Börngen, Wei Zhuang, Nils Griebenow, Claudia Böhm, Niels Lindner, Maike Hink, Ulrich Görgens
-
Publication number: 20200230204Abstract: The present invention relates to the combination of lysobactin with an aminoglycoside antibiotic for use in the treatment of diseases caused by Gram-positive and Gram-negative bacteria in non-human animals. The invention proved to be particularly useful relating to the treatment of mastitis in non-human animals. Particularly bovine mastitis can be well addressed by the present invention.Type: ApplicationFiled: February 14, 2018Publication date: July 23, 2020Applicant: Bayer Animal Health GmbHInventors: Guido SCHIFFER, Stefan FÄLKER, Gert DAUBE, Wolfgang WIEHL, Johannes KÖBBERLING
-
Publication number: 20200190111Abstract: The present invention covers bicyclic pyrazole compounds of general formula (I): in which G, A, R1, R2, R3, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 23, 2018Publication date: June 18, 2020Applicant: Bayer Animal Health GMBHInventors: Nils GRIEBENOW, Wei ZHUANG, Daniel KULKE, Adeline KÖHLER, Thomas ILG, Claudia WELZ, Hans-Georg SCHWARZ, Ulrich GÖRGENS, Walter HÜBSCH, Johannes KÖBBERLING
-
Patent number: 10668071Abstract: The present application relates to novel substituted (aza)pyridopyrazolopyrimidinones and indazolopyrimidinones, to processes for their preparation, the compounds for use alone or in combinations in a method for the treatment and/or prophylaxis of diseases, in particular for the treatment and/or prophylaxis of acute and recurrent bleeding in patients with or without underlying hereditary or acquired bleeding disorders, wherein the bleeding is associated with a disease or medical intervention selected from the group consisting of menorrhagia, postpartum hemorrhage, hemorrhagic shock, trauma, surgery, transplantation, stroke, liver diseases, hereditary angioedema, nosebleed, and synovitis and cartilage damage following hemarthrosis.Type: GrantFiled: August 10, 2018Date of Patent: June 2, 2020Assignee: BAYER PHARMA AKTIENGESELLSCHAFTInventors: Jorma Haßfeld, Tom Kinzel, Johannes Köbberling, Yolanda Cancho-Grande, Kristin Beyer, Susanne Röhrig, Maria Köllnberger, Michael Sperzel, Nils Burkhardt, Karl-Heinz Schlemmer, Christian Stegmann, Joachim Schuhmacher, Matthias Werner, Manuel Ellermann
-
Patent number: 10604525Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: GrantFiled: April 10, 2017Date of Patent: March 31, 2020Assignee: BAYAL ANIMAL HEALTH GMBHInventors: Adeline Köhler, Claudia Welz, Kirsten Börngen, Daniel Kulke, Thomas Ilg, Johannes Köbberling, Walter Hübsch, Hans-Georg Schwarz, Ulrich Görgens, Ulrich Ebbinghaus-Kintscher, Maike Hink, Dirk Nennstiel, Klaus Raming, Martin Adamczewski, Claudia Böhm, Nils Griebenow, Wei Zhuang
-
Publication number: 20200024264Abstract: The present invention covers new quinoline compounds of general formula (I) in which A, R1, R2, R3, R4, R5, R6, and Q are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: November 6, 2017Publication date: January 23, 2020Applicant: Bayer Animal Health GMBHInventors: Walter HÜBSCH, Johannes KÖBBERLING, Adeline KÖHLER, Hans-Georg SCHWARZ, Daniel KULKE, Claudia WELZ, Thomas ILG, Kirsten BÖRNGEN, Wei ZHUANG, Nils GRIEBENOW, Claudia BÖHM, Niels LINDNER, Maike HINK, Ulrich GÖRGENS
-
Patent number: 10357036Abstract: The invention relates inter alia to compounds of the general formula (I). Also described are methods for preparing the compounds of the formula (I). The compounds according to the invention are especially suitable for controlling insects, arachnids and nematodes in agriculture, and ectoparasites in veterinary medicine and also as herbicides.Type: GrantFiled: August 11, 2016Date of Patent: July 23, 2019Assignee: Bayer CropScience AktiengesellschaftInventors: Tobias Harschneck, Michael Maue, Werner Hallenbach, Alexander Arlt, Robert Velten, Reiner Fischer, Hans-Georg Schwarz, Ulrich Görgens, Kerstin Ilg, Klaus Raming, Sebastian Horstmann, Daniela Portz, Johannes Köbberling, Andreas Turberg, Hansjörg Dietrich
-
Patent number: 10273226Abstract: The invention comprises, inter alia, pyrazolylheteroarylamides of the general formula (I) in which the A1-A4, T, W, Q, R1 and Z1-Z3 radicals are each as defined in the description. Also described are processes for preparing the compounds of the formula (I). The inventive compounds are especially suitable for controlling insects, arachnids and nematodes in agriculture and ectoparasites in veterinary medicine.Type: GrantFiled: December 30, 2014Date of Patent: April 30, 2019Assignee: BAYER ANIMAL HEALTH GMBHInventors: Hans-Georg Schwarz, Michael Maue, Kerstin Ilg, Ulrich Görgens, Andreas Turberg, Sebastian Horstmann, Johannes Köbberling, Niels Lindner
-
Publication number: 20190071447Abstract: The present invention covers Pyrazolopyrimidine compounds of general formula (I), in which n, o, X, Y, R, Q, R1, R2, R3 and R4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment, control and/or prevention of diseases, in particular of helminth infections, as a sole agent or in combination with other active ingredients.Type: ApplicationFiled: April 10, 2017Publication date: March 7, 2019Applicant: BAYER ANIMAL HEALTH GMBHInventors: Adeline KÖHLER, Claudia WELZ, Kirsten BÖRNGEN, Daniel KULKE, Thomas ILG, Johannes KÖBBERLING, Walter HÜBSCH, Hans-Georg SCHWARZ, Ulrich GÖRGENS, Ulrich EBBINGHAUS-KINTSCHER, Maike HINK, Dirk NENNSTIEL, Klaus RAMING, Martin ADAMCZEWSKI, Claudia BÖHM
-
Patent number: 10202351Abstract: The invention comprises novel pyrazolyl derivatives of the general formula (I) Also described are processes for preparing the compounds of the formula (I). The compounds according to the invention are especially suitable for controlling insects and archnids in agriculture, and ectoparasites in veterinary medicine.Type: GrantFiled: March 9, 2016Date of Patent: February 12, 2019Assignee: BAYER ANIMAL HEALTH GMBHInventors: Hans-Georg Schwarz, Michael Maue, Werner Hallenbach, Ulrich Görgens, Daniela Portz, Kerstin Ilg, Johannes Köbberling, Andreas Turberg