Abstract: Pharmaceutical compositions containing tetrathiomolybdate (TTM) are disclosed. Pharmaceutical compositions and formulations that contain TTM along with other co-drugs, such as diethylcarbamazine (DEC) and astaxanthin (ATX), are also disclosed. Formulations include a delayed release oral form that releases the TTM in the gastrointestinal tract after the oral form passes the stomach, and an enteric oral form that is not a delayed release form are disclosed. Methods of treating cancer, treating cancer patients as an adjuvant therapy, and treating pulmonary arterial hypertension by administering the pharmaceutical compositions are further disclosed.

Abstract: A method of determining information indicative of a material attribute of a composition, wherein the method comprises manufacturing the composition using a thermal manufacturing process, detecting detection data from the composition by low coherence interferometry during the manufacturing, in particular during said thermal manufacturing process, and determining the information based on the detected detection data.

Abstract: A device and a method for providing granular matter is described. The device includes a receiving container configured and adjusted for receiving the granular matter. The receiving container has an output for providing the granular matter to a further processing. The device has a measuring unit configured for measuring a density of the granular matter in the receiving container using terahertz spectroscopy.

Abstract: A system and a method for a constant micro dosing of powder material include a control device, a cylinder with a first opening and a piston movably arranged inside the cylinder and controllable by the control device. The piston is movable in the direction to or away from the first opening along a piston stroke direction. The cylinder stores the powder material between the piston and the first opening. The piston pushes the powder material through the first opening by moving along the piston stroke direction. Further the system and the method include a removing device for removing the powder material which is pushed out of the first opening of the cylinder. The control device controls the piston and the removing device in a synchronized manner such that a predetermined amount of powder material pushed through the first opening is removable by the removing device.

Abstract: A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process is disclosed. The method includes at least partially dissolving the dosage form, and during the dissolution of the dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.

Abstract: A system and a method for a constant micro dosing of powder material include a control device, a cylinder with a first opening and a piston movably arranged inside the cylinder and controllable by the control device. The piston is movable in the direction to or away from the first opening along a piston stroke direction. The cylinder stores the powder material between the piston and the first opening. The piston pushes the powder material through the first opening by moving along the piston stroke direction. Further the system and the method include a removing device for removing the powder material which is pushed out of the first opening of the cylinder. The control device controls the piston and the removing device in a synchronized manner such that a predetermined amount of powder material pushed through the first opening is removable by the removing device.

Abstract: There is provided an apparatus for molding a thermoplastic material into a homogenous sample body having a predetermined shape, the apparatus comprising: (a) a main body (110) comprising a first opening (112), a second opening and a hollow bore (116) connecting the first opening (112) with the second opening, the hollow bore (116) being adapted to receive a separation foil shaped to cover at least a part of the hollow bore surface; (b) a piston (120) adapted to fit moveably into the hollow bore (116) containing the separation foil; (c) a base plate (130) comprising a protrusion, wherein the base plate (130) is adapted to be inserted into the first opening (112) in such a manner that the protrusion extends into a part of the hollow bore (116) containing the separation foil, and wherein the base plate (130) is adapted to transfer heat from a heating unit to a thermoplastic material (150) resting on the protrusion (132); (d) a vacuum connector (142) adapted to be connected to a vacuum source; (e) a lid (140) ada

Abstract: A method of monitoring a property of a dissolution of an at least partially solid dosage form during a dissolution process is disclosed. The method includes at least partially dissolving the dosage form, and during the dissolution of the dosage form, simultaneously monitoring the property of the dissolution of the dosage form in progress by low coherence interferometry.

Abstract: There is provided an apparatus for molding a thermoplastic material into a homogenous sample body having a predetermined shape, the apparatus comprising: (a) a main body (110) comprising a first opening (112), a second opening and a hollow bore (116) connecting the first opening (112) with the second opening, the hollow bore (116) being adapted to receive a separation foil shaped to cover at least a part of the hollow bore surface; (b) a piston (120) adapted to fit moveably into the hollow bore (116) containing the separation foil; (c) a base plate (130) comprising a protrusion, wherein the base plate (130) is adapted to be inserted into the first opening (112) in such a manner that the protrusion extends into a part of the hollow bore (116) containing the separation foil, and wherein the base plate (130) is adapted to transfer heat from a heating unit to a thermoplastic material (150) resting on the protrusion (132); (d) a vacuum connector (142) adapted to be connected to a vacuum source; (e) a lid (140) ada

Abstract: A method and a device for monitoring a property of a coating of a solid dosage form during a coating process forming the coating of the solid dosage form are provided. The device comprises a coating apparatus configured for forming the coating on the solid dosage form, and a monitoring apparatus configured for monitoring the property of the coating of the solid dosage form in process, wherein at least a part of the monitoring apparatus is located so as to have insight in an interior of the coating apparatus, the interior accommodating the solid dosage form to be coated and a precursor for forming the coating, and wherein the monitoring apparatus is configured for monitoring the property of the coating of the solid dosage form simultaneously with and during a coating process using low coherence interferometry.

Abstract: An embodiment of the invention relates to an apparatus for manufacturing particles, wherein the apparatus comprises a supply unit adapted for supplying a viscous raw material, a perforated body having a plurality of perforations and arranged to receive the viscous raw material from the supply unit to flow through the plurality of perforations, and a cutter arranged so that the viscous raw material flowing out of the plurality of perforations is cut into the particles by the cutter, wherein the apparatus is configured so that, during manufacturing the particles, a temperature of at least a portion of the perforated body is lower than a temperature of the viscous raw material flowing through the plurality of perforations, wherein the perforated body and the cutter are arranged relative to one another such that the cutter is cooled by thermal exchange with the perforated body during operation of the apparatus.

Abstract: A method and a device for monitoring a property of a coating of a solid dosage form during a coating process forming the coating of the solid dosage form are provided. The device comprises a coating apparatus configured for forming the coating on the solid dosage form, and a monitoring apparatus configured for monitoring the property of the coating of the solid dosage form in process, wherein at least a part of the monitoring apparatus is located so as to have insight in an interior of the coating apparatus, the interior accommodating the solid dosage form to be coated and a precursor for forming the coating, and wherein the monitoring apparatus is configured for monitoring the property of the coating of the solid dosage form simultaneously with and during a coating process using low coherence interferometry.

Abstract: An apparatus for manufacturing a medication comprising an ejector unit adapted for ejecting a predefined amount of a drug having a liquid component to a solid carrier substrate. The ejector unit comprises a capillary and a tubular piezoelectric actuator surrounding at least a part of the capillary. The apparatus further comprises a control unit adapted for applying an electric signal to the piezoelectric actuator which, in response to the electric signal, is adapted to generate a compressional wave in the capillary for ejecting the predefined amount of the drug via an orifice of the capillary. Moreover, a method of manufacturing a medication is provided, the method comprising ejecting a predefined amount of a drug having a liquid component to a solid carrier substrate. Furthermore, a medication is provided comprising a solid carrier substrate, and a predefined amount of a drug ejected with a liquid component to the solid carrier substrate by an ejector unit.