Patents by Inventor Johannes L. Bos

Johannes L. Bos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probes for detecting activated RAS oncogenes
    Patent number: 5847095
    Abstract: Molecules complementary to nucleotide sequences encoding mutant ras proteins which contain a single-base mutation in the codon encoding amino acids at position 13, 12 or 61 have been produced. These molecules are useful in methods of detecting specific single-base mutations in altered ras genes and the specific cancers associated with such mutations.
    Type: Grant
    Filed: January 3, 1997
    Date of Patent: December 8, 1998
    Assignee: The Board of Rijks Universiteit Leiden
    Inventors: Johannes L. Bos, Alex J. van der Eb
  • Methods for detecting activated RAS oncogenes
    Patent number: 5591582
    Abstract: Molecules complementary to nucleotide sequences encoding mutant ras proteins which contain a single-base mutation in the codon encoding amino acids at position 13, 12 or 61 have been produced. These molecules are useful in methods of detecting specific single-base mutations in altered ras genes and the specific cancers associated with such mutations.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: January 7, 1997
    Assignee: The Board of Rijks Universiteit Leiden
    Inventors: Johannes L. Bos, Alex J. van der Eb
  • Probes and methods for detecting activated ras oncogenes
    Patent number: 4871838
    Abstract: Molecules complementary to nucleotide sequences encoding mutant ras protiens which contain a single-base mutation in the codon encoding amino acids at position 13, 12 or 61 have been produced. These molecules are useful in methods of detecting specific single-base mutations in altered ras genes and the specific cancers associated with such mutations.
    Type: Grant
    Filed: July 23, 1985
    Date of Patent: October 3, 1989
    Assignee: The Board of Rijks Universiteit Leiden
    Inventors: Johannes L. Bos, Alex J. Van der Eb