Patents by Inventor Johannes Lambertus van Duijnhoven

Johannes Lambertus van Duijnhoven has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Pharmaceutical composition having an endoproteolytic activity
    Patent number: 6274365
    Abstract: The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process for the in vitro cleavage of a protein by treating the protein in the presence of Ca2+ ions with furin or a furin-like enzyme, or an endoproteolytically active fragment, derivative or fusion protein of furin or furin-like enzyme. The invention can be used for the (micro)biological production of a protein by culturing genetically engineered cells expressing a proform of the protein as well as furin or a furin-like enzyme and isolating the protein formed. The invention also relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers, diluents or adjuvants, as well as an endoproteolytically active amount of furin or a furin-like enzyme, or a fragment or derivative of furin or furin-like enzyme having an endoproteolytic activity.
    Type: Grant
    Filed: October 22, 1997
    Date of Patent: August 14, 2001
    Assignees: Katholieke Universiteit Leuven
    Inventors: Willem Jan van de Ven, Anna Maria van den Ouweland, Johannes Lambertus van Duijnhoven, Antonius Johannes Roebroek, Piet Nico Koning
  • Method for treating mammals having a deficiency in endoprotease
    Patent number: 6132717
    Abstract: The invention is based on the finding the furin belongs to a family of endoproteolytically active enzymes and relates to a process in the in vitro cleavage of a protein by treating the protein in the presence of a Ca.sup.2+ ions with furin, or an endoproteolytically active fragment, derivative or fusion protein of furin. The invention can be used for the (micro) biological production of a protein by culturing genetically engineered cells expressing a pro-form of the protein as well as furin and isolating the protein formed. The invention also relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers, diluents or adjuvants, as well as an endoproteolytically active amount of furin, or a fragment or derivative of furin having an endoproteolytic activity.
    Type: Grant
    Filed: February 19, 1999
    Date of Patent: October 17, 2000
    Assignees: Katholieke Universiteit Leuven, William Jan Marie van de Ven
    Inventors: Willem Jan van de Ven, Anna Maria van den Ouweland, Johannes Lambertus van Duijnhoven, Antonius Johannes Roebroek, Piet Nico Koning
  • Pharmaceutical composition having an endoproteolytic activity; a process for endoproteolytically processing (precursor) proteins and for the (micro)biological production of proteins
    Patent number: 5989856
    Abstract: The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process for the in vitro cleavage of a protein by treating the protein in the presence of Ca.sup.2+ ions with furin or furin like enzyme, or enzymatically active fragment, derivative or fusion protein of furin or furin-like enzyme.
    Type: Grant
    Filed: June 24, 1992
    Date of Patent: November 23, 1999
    Assignee: Katholieke Universiteit Leuven
    Inventors: Willem Jan van de Ven, Anna Maria van den Ouweland, Johannes Lambertus van Duijnhoven, Antonius Johannes Roebroek, Piet Nico Koning
  • Process for micro biological production of proteins
    Patent number: 5935815
    Abstract: The invention is based on the finding that furin belongs to a family of endoproteolytically active enzymes and relates to a process in the in vitro cleavage of a protein by treating the protein in the presence of Ca.sup.2+ ions with furin, or an endoproteolytically active fragment, derivative or fusion protein of furin. The invention can be used for the (micro) biological production of a protein by culturing genetically engineered cells expressing a pro-form of the protein as well as furin and isolating the protein formed. The invention also relates to a pharmaceutical composition comprising one or more pharmaceutically acceptable carriers, diluents or adjuvants, as well as an endoproteolytically active amount of furin, or a fragment or derivative of furin having an endoproteolytic activity.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: August 10, 1999
    Assignee: Katholieke Universiteit Leuven
    Inventors: Willem Jan van de Ven, Anna Maria van den Ouweland, Johannes Lambertus van Duijnhoven, Antonius Johannes Roebroek, Piet Nico Koning