Patents by Inventor Johannes LANGLER

Johannes LANGLER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ADENO ASSOCIATED VIRUS BASED GENE THERAPY FOR PHENYLKETONURIA
    Publication number: 20230055020
    Abstract: The present disclosure provides, among other things, a recombinant adeno-associated virus (rAAV) vector comprising an AAV8 capsid and a codon-optimized sequence encoding a human phenylalanine hydroxylase (PAH) enzyme. The disclosure also provides a method of treating a subject having phenylketonuria (PKU), comprising administering to the subject in need thereof a recombinant adeno-associated vims (rAAV) vector comprising an AAV8 capsid, and a promoter operably linked to a nucleic acid sequence that encodes PAH, and wherein administering results in a decrease in phenylalanine level in the subject.
    Type: Application
    Filed: January 15, 2021
    Publication date: February 23, 2023
    Inventors: Matthias KLUGMANN, Hanspeter ROTTENSTEINER, Franziska HORLING, Johannes LANGLER