Abstract: A circuit arrangement and a method with a DC voltage supply, a DC voltage intermediate circuit, a power converter, a control device for the power converter, and with a braking resistor. The power converter is formed as a multi-phase bridge circuit having at least one, preferably at least two first half bridge circuit(s) and having at least one, preferably at least two second half bridge circuit(s), which are each connected to the DC voltage intermediate circuit. A first resistor terminal of the braking resistor is connected to the middle tap of the first bridge circuit, and wherein a second resistor terminal of the braking resistor is connected to the middle tap of the second bridge circuit.

Abstract: A device assembly for controlling an integrated continuous pharmaceutical or biopharmaceutical manufacturing process including a first process equipment for performing a first process step; a second process equipment for performing a second process step subsequent to the first process step; a single measuring unit for measurement of a set of signals of a liquid process medium at a single location, the measured signals depending on first and second parameters; and an evaluation and control unit for evaluating the measured signals to determine values of the first and second parameters. The evaluation and control unit determines first and second corrective feedback based on the values of the first and second parameters, respectively. The evaluation and control unit controls the first process step by providing the first corrective feedback to the first process equipment and controls the second process step by providing the second corrective feedback to the second process equipment.

Abstract: A system for an automated production of high cell density seed culture, HCDC, preparations, for cryo-preservation comprising a cell expansion device for growing a HCDC in a medium inside a device volume of the cell expansion device, at least one sensor for collecting data by at least temporally monitoring at least one parameter being indicative of the physiological state of the HCDC; and a control unit for processing the collected data to determine whether at least one predetermined criterion is fulfilled by the monitored parameter to control, based on whether the at least one predetermined criterion is fulfilled by the monitored parameter, at least a partial exchange of the medium by a cryo-protective agent, CPA.