Abstract: A system includes a random signal generator and a processor. The random signal generator generates detection signals of radioactive decay events. The random signal generator includes a detector and a metal tritide device disposed at the detector. The detector generates the detection signals based on detection of beta particles from radioactive decay of tritium. The detection signals include randomized timing information of the radioactive decay events. The metal tritide device includes the tritium. The tritium in the metal tritide device undergoes radioactive decay to emit the beta particles. The processor generates a random value based on the detection signals of the radioactive decay events.

Abstract: Gearwheel for structure-borne sound reduction in electric drives, having a toothed ring and a wheel hub, which has a structured annular or corrugated web between a shaft seat and the toothed ring. The web has a structure designed with deviations from uniform stiffness and mass distribution about an axis of rotation of the gearwheel, and has an axial symmetry to avoid imbalance. The gearwheel has a two-fold, four-fold, six-fold or eight-fold cyclic axial symmetry.

Abstract: The invention relates to the combined use and to a combination of either a microtubule targeting agent or a Src kinase inhibitor, a Raf-MEK-ERK pathway inhibitor and an EGFR and/or ERBB2 inhibitor for use in the treatment of RAS-mutant cancer. The invention further relates to a method of treating RAS-mutant cancers and to a method of testing a combination comprising of a either microtubule targeting agent or a Src inhibitor, a Raf-MEK-ERK pathway inhibitor and an EGFR and/or ERBB2 inhibitor on a tumor organoid. In particular, the invention relates to the combined use of either a microtubule targeting agent or a Src kinase inhibitor with: an inhibitor of the Raf-MEK-ERK pathway and at least one of an inhibitor of both EGFR and ERBB2 and a combination of an EGFR inhibitor and an ERBB2 inhibitor in the treatment of RAS mutant cancer.

Abstract: A portal axle drive for a vehicle axle of an electric vehicle with driving wheels includes a drive shaft (AN) with an input axis (a) and an output shaft (AB) with an output and wheel axis (b). The input axis (a) and the output axis (b) have an axial or portal offset (c). A first gear stage (Ü1) is arranged between the drive shaft (AN) and the output shaft (AB). In an axial direction, a second gear stage (Ü2) is arranged next to the first gear stage (Ü1) and an engagement device (SE) is arranged next to the second gear stage (Ü2). The first gear stage (Ü1) and the second gear stage (Ü2) are engageable via the engagement device (SE).

Abstract: Gearwheel for structure-borne sound reduction in electric drives, having a toothed ring and a wheel hub, which has a structured annular or corrugated web between a shaft seat and the toothed ring. The web has a structure designed with deviations from uniform stiffness and mass distribution about an axis of rotation of the gearwheel, and has an axial symmetry to avoid imbalance. The gearwheel has a two-fold, four-fold, six-fold or eight-fold cyclic axial symmetry.

Abstract: The invention relates to the combined use and to a combination of either a microtubule targeting agent or a Src kinase inhibitor, a Raf-MEK-ERK pathway inhibitor and an EGFR and/or ERBB2 inhibitor for use in the treatment of RAS-mutant cancer. The invention further relates to a method of treating RAS-mutant cancers and to a method of testing a combination comprising of a either microtubule targeting agent or a Src inhibitor, a Raf-MEK-ERK pathway inhibitor and an EGFR and/or ERBB2 inhibitor on a tumor organoid. In particular, the invention relates to the combined use of either a microtubule targeting agent or a Src kinase inhibitor with: an inhibitor of the Raf-MEK-ERK pathway and at least one of an inhibitor of both EGFR and ERBB2 and a combination of an EGFR inhibitor and an ERBB2 inhibitor in the treatment of RAS mutant cancer.

Abstract: A portal axle drive for a vehicle axle of an electric vehicle with driving wheels includes a drive shaft (AN) with an input axis (a) and an output shaft (AB) with an output and wheel axis (b). The input axis (a) and the output axis (b) have an axial or portal offset (c). A first gear stage (Ü1) is arranged between the drive shaft (AN) and the output shaft (AB). In an axial direction, a second gear stage (Ü2) is arranged next to the first gear stage (Ü1) and an engagement device (SE) is arranged next to the second gear stage (Ü2). The first gear stage (Ü1) and the second gear stage (Ü2) are engageable via the engagement device (SE).