Patents by Inventor Johannes N. Koek

Johannes N. Koek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hydroxylated ene ketones, acetylenic grignards and hydroxylated yne ketones therefrom
    Patent number: 4973756
    Abstract: An alpha-hydroxyl-alpha,alpha-di(inert-substituted)-gamma',delta'-yne ketone can be prepared by a procedure comprising contacting an acetylenic Grignard reagent with an alpha-hydroxyl-alpha,alpha-di(inert substituted)-alpha',beta'-ene ketone, and the alpha-hydroxyl-alpha,alpha-di(inert-substituted)-alpha',beta'-ene ketone can be prepared by a procedure comprising steps of contacting, first, an alkoxy allene with a lithium donating organic agent, second, product of the first step with a di(inert-substituted)ketone, and third, product of the second step with an acidic substance.
    Type: Grant
    Filed: August 21, 1989
    Date of Patent: November 27, 1990
    Assignee: Marion Laboratories, Inc.
    Inventors: Hans Wynberg, Wolter T. Hoeve, Gerrit A. Barf, Johannes N. Koek, David R. Borcherding
  • Thermochemiluminescent cyclodextrin complexes
    Patent number: 4935407
    Abstract: Thermochemiluminescent complexes of an adamanthylideneadamantane 1,2-dioxetane and a cyclodextrin are non-volatile at the temperatures used to excite the thermochemiluminescence. The complexes can be encapsulated in immunosensitized microcapsules, e.g., liposomes, to provide a labeled immunoreagent useful in immunoassay using thermochemiluminescent labeled immunoreagents.
    Type: Grant
    Filed: September 22, 1987
    Date of Patent: June 19, 1990
    Assignee: Akzo N.V.
    Inventors: Theo M. Luider, Jan C. Hummelen, Johannes N. Koek, Hans Wynberg