Patents by Inventor Johannes Nicolaas Koek

Johannes Nicolaas Koek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]-methyl]-2,4-thiazolidinedione and salts thereof
    Patent number: 11731963
    Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification.
    Type: Grant
    Filed: September 20, 2021
    Date of Patent: August 22, 2023
    Assignee: Minoryx Therapeutics S.L.
    Inventors: Ana Maria García Collazo, Wolter Ten Hoeve, Johannes Nicolaas Koek, Johannes B. M. Rewinkel, Sander De Wilde
  • PROCESS FOR PREPARING 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY]PHENYL]-METHYL]-2,4-THIAZOLIDINEDIONE AND SALTS THEREOF
    Publication number: 20220204496
    Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof; and the process of making the intermediate of Formula III; wherein PG is as defined as set forth in the specification.
    Type: Application
    Filed: September 20, 2021
    Publication date: June 30, 2022
    Applicant: Minoryx Therapeutics S.L.
    Inventors: Ana Maria GARCÍA COLLAZO, Wolter TEN HOEVE, Johannes Nicolaas KOEK, Johannes B.M. REWINKEL, Sander DE WILDE
  • Process for preparing 5-[[4-[2-[5-(1-hydroxyethyl)-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione and salts thereof
    Patent number: 11124505
    Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof: and the process of making the intermediate of Formula III: wherein PG is as defined as set forth in the specification.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: September 21, 2021
    Assignee: Minoryx Therapeutics S.L.
    Inventors: Ana Maria García Collazo, Wolter Ten Hoeve, Johannes Nicolaas Koek, Johannes B. M. Rewinkel, Sander De Wilde
  • PROCESS FOR PREPARING 5-[[4-[2-[5-(1-HYDROXYETHYL)-2-PYRIDINYL]ETHOXY]PHENYL]METHYL]-2,4-THIAZOLIDINEDIONE AND SALTS THEREOF
    Publication number: 20190389852
    Abstract: The disclosure provides a process of making the compound of Formula I, and pharmaceutically acceptable salts thereof: and the process of making the intermediate of Formula III: wherein PG is as defined as set forth in the specification.
    Type: Application
    Filed: December 22, 2017
    Publication date: December 26, 2019
    Applicant: Minoryx Therapeutics S.L.
    Inventors: Ana Maria GARCÍA COLLAZO, WoIter TEN HOEVE, Johannes Nicolaas KOEK, Johannes B.M. REWINKEL, Sander DE WILDE
  • Process for the separation of enantiomers of piperazine derivatives
    Patent number: 10344021
    Abstract: The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-racemic, chiral acid.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: July 9, 2019
    Assignee: Asceneuron S A
    Inventors: Anna Quattropani, Santosh S. Kulkarni, Awadut Gajendra Giri, Johannes Nicolaas Koek
  • PROCESS FOR THE SEPARATION OF ENANTIOMERS OF PIPERAZINE DERIVATIVES
    Publication number: 20190062316
    Abstract: The invention relates to a process for preparing either enantiomer of a compound of formula (I), wherein X, Y and n have the meaning given in claim 1, with high enantiomeric excess (e.e.), by chiral resolution in the presence of a non-racemic, chiral acid.
    Type: Application
    Filed: February 24, 2017
    Publication date: February 28, 2019
    Inventors: Anna QUATTROPANI, Santosh S. KULKARNI, Awadut Gajendra GIRI, Johannes Nicolaas KOEK
  • NOVEL PROCESSES FOR THE PREPARATION OF (R)-ALPHA-(2,3-DIMETHOXYPHENYL)-1-[2-(4-FLUOROPHENYL)ETHYL]-4-PIPERIDINEMETHANOL
    Publication number: 20090227798
    Abstract: The present invention provides various processes for the preparation of (R)-?-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: March 13, 2009
    Publication date: September 10, 2009
    Applicants: SANOFI-AVENTIS DEUTSCHLAND GMBH, AVENTIS PHARMACEUTICALS INC.
    Inventors: Wolfgang Laux, Gerard Guillamot, Frederick M. Laskovics, Chi-Hsin R. King, James E. Hitt, Sandra K. Stolz-Dunn, Ian A. Tomlinson, Johannes Nicolaas Koek
  • Processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
    Patent number: 6713627
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Grant
    Filed: January 11, 2002
    Date of Patent: March 30, 2004
    Assignee: Aventis Pharmaceuticals Inc.
    Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson
  • Novel processes for the preparation or (R)-alpha-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol
    Publication number: 20020151717
    Abstract: The present invention provides various processes for the preparation of (R)-&agr;-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperidinemethanol.
    Type: Application
    Filed: January 11, 2002
    Publication date: October 17, 2002
    Inventors: Edward D. Daugs, Jonathan C. Evans, Hans-Wolfram Flemming, Thomas Heinz Eduard Hilpert, Johannes Nicolaas Koek, Frederick M. Laskovics, Sandra K. Stolz-Dunn, Ian A. Tomlinson