Patents by Inventor Johannes Pieter van Dijken
Johannes Pieter van Dijken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11634735Abstract: The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.Type: GrantFiled: July 1, 2020Date of Patent: April 25, 2023Assignee: Lallemand Hungary Liquidity Management LLCInventors: John E. McBride, Vineet Rajgarhia, Arthur J. Shaw, IV, Shital A. Tripathi, Elena Brevnova, Nicky Caiazza, Johannes Pieter Van Dijken, Allan C. Froehlich, William Ryan Sillers, James H. Flatt
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Publication number: 20210277427Abstract: The present invention provides for novel metabolic pathways to detoxify biomass-derived acetate via metabolic conversion to ethanol, acetone, or isopropanol. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more first engineered metabolic pathways to achieve: (1) conversion of acetate to ethanol; (2) conversion of acetate to acetone; or (3) conversion of acetate to isopropanol; and one or more native and/or heterologous enzymes that function in one or more second engineered metabolic pathways to produce an electron donor used in the conversion of acetate to less inhibitory compounds; wherein the one or more native and/or heterologous enzymes is activated, upregulated, or downregulated.Type: ApplicationFiled: May 13, 2021Publication date: September 9, 2021Inventors: Rintze Meindert Zelle, Arthur J. Shaw, IV, Johannes Pieter Van Dijken
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Publication number: 20200325500Abstract: The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.Type: ApplicationFiled: July 1, 2020Publication date: October 15, 2020Inventors: John E. McBride, Vineet Rajgarhia, Arthur J. Shaw, IV, Shital A. Tripathi, Elena Brevnova, Nicky Caiazza, Johannes Pieter Van Dijken, Allan C. Froehlich, William Ryan Sillers, James H. Flatt
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Patent number: 10760105Abstract: Disclosed are transformed cells comprising one or more genetic modifications that increase the lipid content of the cell, e.g., relative to an unmodified cell of the same type. Also disclosed are methods for increasing the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the cell.Type: GrantFiled: December 29, 2015Date of Patent: September 1, 2020Assignee: NOVOGY, INC.Inventors: Arthur J. Shaw, IV, Johannes Pieter Van Dijken, Annapurna Kamineni, Jonathan Friedlander, Vasiliki Tsakraklides, Maureen Hamilton, Elena E. Brevnova
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Publication number: 20200095613Abstract: The present invention provides for novel metabolic pathways to detoxify biomass-derived acetate via metabolic conversion to ethanol, acetone, or isopropanol. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more first engineered metabolic pathways to achieve: (1) conversion of acetate to ethanol; (2) conversion of acetate to acetone; or (3) conversion of acetate to isopropanol; and one or more native and/or heterologous enzymes that function in one or more second engineered metabolic pathways to produce an electron donor used in the conversion of acetate to less inhibitory compounds; wherein the one or more native and/or heterologous enzymes is activated, unregulated, or downregulated.Type: ApplicationFiled: December 4, 2019Publication date: March 26, 2020Inventors: Rintze Meindert Zelle, Arthur J. Shaw, IV, Johannes Pieter Van Dijken
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Publication number: 20180208951Abstract: The present in provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.Type: ApplicationFiled: March 21, 2018Publication date: July 26, 2018Inventors: John E. McBride, Vineet Rajgarhia, Arthur J. Shaw, IV, Shital A. Tripathi, Elena Brevnova, Nicky Caiazza, Johannes Pieter Van Dijken, Allan C. Froehlich, William Ryan Sillers, James H. Flatt
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Patent number: 9957530Abstract: The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, upregulated or downregulated.Type: GrantFiled: August 20, 2010Date of Patent: May 1, 2018Assignee: Lallemand Hungary Liquidity Management LLCInventors: John E. McBride, Vineet Rajgarhia, Arthur J. Shaw, IV, Shital A. Tripathi, Elena Brevnova, Nicky Caiazza, Johannes Pieter Van Dijken, Allan C. Froehlich, William Ryan Sillers, James H. Flatt
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Publication number: 20170369912Abstract: Disclosed are transformed cells comprising one or more genetic modifications that increase the lipid content of the cell, e.g., relative to an unmodified cell of the same type. Also disclosed are methods for increasing the lipid content of a cell by increasing the activity of one or more proteins in the cell and/or by decreasing the activity of one or more proteins in the cell.Type: ApplicationFiled: December 29, 2015Publication date: December 28, 2017Inventors: Arthur J. SHAW, IV, Johannes Pieter VAN DIJKEN, Annapurna KAMINENI, Jonathan FRIEDLANDER, Vasiliki TSAKRAKLIDES, Maureen HAMILTON, Elena E. BREVNOVA
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Patent number: 9803221Abstract: The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting organisms that have been genetically modified to allow the production of ethanol at a high yield by redirecting carbon flux at key steps of central metabolism.Type: GrantFiled: September 28, 2012Date of Patent: October 31, 2017Assignees: Enchi Corporation, Dartmouth CollegeInventors: Yu Deng, Daniel G. Olson, Johannes Pieter van Dijken, Arthur J. Shaw, IV, Aaron Argyros, Trisha Barrett, Nicky Caiazza, Christopher D. Herring, Stephen R. Rogers, Frank Agbogbo
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Publication number: 20160265005Abstract: The present invention provides for novel metabolic pathways to detoxify biomass-derived acetate via metabolic conversion to ethanol, acetone, or isopropanol. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more first engineered metabolic pathways to achieve: (1) conversion of acetate to ethanol; (2) conversion of acetate to acetone; or (3) conversion of acetate to isopropanol; and one or more native and/or heterologous enzymes that function in one or more second engineered metabolic pathways to produce an electron donor used in the conversion of acetate to less inhibitory compounds; wherein the one or more native and/or heterologous enzymes is activated, unregulated, or downregulated.Type: ApplicationFiled: May 10, 2016Publication date: September 15, 2016Inventors: Rintze Meindert Zelle, Arthur J. Shaw, IV, Johannes Pieter Van Dijken
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Patent number: 9303253Abstract: The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol.Type: GrantFiled: January 6, 2012Date of Patent: April 5, 2016Assignee: DSM IP ASSETS B.V.Inventors: Antonius Jeroen Adriaan Van Maris, Jacobus Thomas Pronk, Hendrik Wouter Wisselink, Johannes Pieter Van Dijken, Aaron Adriaan Winkler, Johannes Hendrik Winde
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Publication number: 20150104543Abstract: Improved systems for the biological production of organic acids are described.Type: ApplicationFiled: September 25, 2014Publication date: April 16, 2015Inventors: Aaron Adriaan WINKLER, Abraham Frederik DE HULSTER, Johannes Pieter VAN DIJKEN, Jacobus Thomas PRONK, Joshua TRUEHEART, Kevin T. MADDEN, Carlos Gancedo RODRIGUEZ, Carmen-Lisset Flores MAURIZ, Antonius Jeroen Adriaan VAN MARIS, Jacob C. HARRISON
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Publication number: 20150010943Abstract: The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modifications are aimed at improving the efficiency of xylose metabolism and include, e.g., reduction of nonspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.Type: ApplicationFiled: June 24, 2014Publication date: January 8, 2015Inventors: Aaron Adriaan WINKLER, Sipko Maarten KUYPER, Wilhelmus Theodorus Antonius Maria DE LAAT, Johannes Pieter VAN DIJKEN, Jacobus Thomas PRONK
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Publication number: 20140356921Abstract: The present invention provides for the manipulation of carbon flux in a recombinant host cell to increase the formation of desirable products. The invention relates to cellulose-digesting organisms that have been genetically modified to allow the production of ethanol at a high yield by redirecting carbon flux at key steps of central metabolism.Type: ApplicationFiled: September 28, 2012Publication date: December 4, 2014Applicant: Mascoma CorporationInventors: Yu Deng, Daniel G. Olson, Johannes Pieter van Dijken, Arthur J. Shaw, IV, Aaron Argyros, Trisha Barrett, Nicky Caiazza, Christopher D. Herring, Stephen R. Rogers, Frank Agbogbo
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Publication number: 20140256011Abstract: The present invention provides for novel metabolic pathways to detoxify biomass-derived acetate via metabolic conversion to ethanol, acetone, or isopropanol. More specifically, the invention provides for a recombinant microorganism comprising one or more native and/or heterologous enzymes that function in one or more first engineered metabolic pathways to achieve: (1) conversion of acetate to ethanol; (2) conversion of acetate to acetone; or (3) conversion of acetate to isopropanol; and one or more native and/or heterologous enzymes that function in one or more second engineered metabolic pathways to produce an electron donor used in the conversion of acetate to less inhibitory compounds; wherein the one or more native and/or heterologous enzymes is activated, upregulated, or downregulated.Type: ApplicationFiled: November 8, 2013Publication date: September 11, 2014Inventors: Rintze Meindert ZELLE, Arthur J. Shaw, IV, Johannes Pieter Van Dijken
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Patent number: 8790903Abstract: The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modifications are aimed at improving the efficiency of xylose metabolism and include. e.g., reduction of nonspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.Type: GrantFiled: September 2, 2011Date of Patent: July 29, 2014Assignee: DSM IP Assets B.V.Inventors: Aaron Adriaan Winkler, Sipko Maarten Kuyper, Wilhelmus Theordorus Antonius Maria De Laat, Johannes Pieter Van Dijken, Jacobus Thomas Pronk
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Publication number: 20120322078Abstract: The present invention provides for novel metabolic pathways leading to propanol, alcohol or polyol formation in a consolidated bioprocessing system (CBP), where lignocellulosic biomass is efficiently converted to such products. More specifically, the invention provides for a recombinant microorganism, where the microorganism expresses one or more native and/or heterologous enzymes; where the one or more enzymes function in one or more engineered metabolic pathways to achieve: (1) conversion of a carbohydrate source to 1,2-propanediol, isopropropanol, ethanol and/or glycerol; (2) conversion of a carbohydrate source to n-propanol and isopropanol; (3) conversion of a carbohydrate source to isopropanol and methanol; or (4) conversion of a carbohydrate source to propanediol and acetone; wherein the one or more native and/or heterologous enzymes is activated, up-regulated or down-regulated.Type: ApplicationFiled: August 20, 2010Publication date: December 20, 2012Inventors: John E. Mcbride, Vineet Rajgarhia, Arthur J. Shaw, Shital A. Tripathi, Elena Brevnova, Nicky Caiazza, Johannes Pieter Van Dijken, Allan C. Froehlich, William Ryan Sillers, James H. Flatt
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Publication number: 20120225451Abstract: The present invention relates to genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers on the host cell the ability to isomerize xylose to xylulose. These genetic modifications are aimed at improving the efficiency of xylose metabolism and include. e.g., reduction of nonspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.Type: ApplicationFiled: September 2, 2011Publication date: September 6, 2012Applicant: Technische Universiteit DelftInventors: Aaron Adriaan WINKLER, Sipko Maarten Kuyper, Wilhelmus Theodorus Antonius Maria De Laat, Johannes Pieter Van Dijken, Jacobus Thomas Pronk
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Publication number: 20120208231Abstract: The invention relates to an eukaryotic cell expressing nucleotide sequences encoding the ara A, ara B and ara D enzymes whereby the expression of these nucleotide sequences confers on the cell the ability to use L-arabinose and/or convert L-arabinose into L-ribulose, and/or xylulose 5-phosphate and/or into a desired fermentation product such as ethanol. Optionally, the eukaryotic cell is also able to convert xylose into ethanol.Type: ApplicationFiled: January 6, 2012Publication date: August 16, 2012Applicant: DSM IP ASSETS B.V.Inventors: Antonius Jeroen Adriaan VAN MARIS, Jacobus Thomas PRONK, Hendrik Wouter WISSELINK, Johannes Pieter VAN DIJKEN, Aaron Adriaan WINKLER, Johannes Hendrik DE WINDE
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Patent number: 8034591Abstract: The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerizing xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction of unspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.Type: GrantFiled: July 15, 2005Date of Patent: October 11, 2011Assignee: Techische Universiteit DelftInventors: Aaron Adriaan Winkler, Sipko Maarten Kuyper, Wilhelmus Theodorus Antonius Maria De Laat, Johannes Pieter Van Dijken, Jacobus Thomas Pronk