Patents by Inventor Johannes Pill
Johannes Pill has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20230132361Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.Type: ApplicationFiled: August 13, 2021Publication date: April 27, 2023Inventors: Ralf Heinrich, Johannes Pill, Sabine Neudecker, Daniel Schock-Kusch, Juergen Guenther, Stefan Koenig, Jochen Friedemann
-
Publication number: 20220047724Abstract: The invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, diagnostic compositions comprising the conjugates, their use, and their production.Type: ApplicationFiled: October 29, 2021Publication date: February 17, 2022Inventors: Leopoldo DELLA CIANA, Norbert GRETZ, Rossana PERCIACCANTE, Federica RODEGHIERO, Stefania GERACI, Jiaguo HUANG, Zeneida HERRERA PÉREZ, Johannes PILL, Stefanie WEINFURTER
-
Publication number: 20220022753Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.Type: ApplicationFiled: August 13, 2021Publication date: January 27, 2022Inventors: Ralf Heinrich, Johannes Pill, Sabine Neudecker, Daniel Schock-Kusch, Juergen Guenther, Stefan Koenig, Jochen Friedemann
-
Patent number: 11179481Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.Type: GrantFiled: August 30, 2019Date of Patent: November 23, 2021Assignee: CYANAGEN S.R.L.Inventors: Leopoldo Della Ciana, Norbert Gretz, Rossana Perciaccante, Federica Rodeghiero, Stefania Geraci, Jiaguo Huang, Zeneida Herrera Pérez, Johannes Pill, Stefanie Weinfurter
-
Patent number: 11122979Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.Type: GrantFiled: February 28, 2019Date of Patent: September 21, 2021Assignee: MediBeacon Inc.Inventors: Ralf Heinrich, Johannes Pill, Sabine Neudecker, Daniel Schock-Kusch, Juergen Guenther, Stefan Koenig, Jochen Friedemann
-
Publication number: 20210052207Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.Type: ApplicationFiled: August 17, 2020Publication date: February 25, 2021Inventors: Norbert Gretz, Johannes Pill, Daniel Schock-Kusch, Thomas Walter, Jürgen Hesser, Maliha Sadick, Felix Eickemeyer, Jae Hyung Hwang, Christian Schildknecht, Soichi Watanabe, Wolfgang Wach, Thomas Rose
-
Patent number: 10765354Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.Type: GrantFiled: September 16, 2016Date of Patent: September 8, 2020Assignee: MediBeacon Inc.Inventors: Norbert Gretz, Johannes Pill, Daniel Schock-Kusch, Thomas Walter, Jürgen Hesser, Maliha Sadick, Felix Eickemeyer, Jae Hyung Hwang, Christian Schildknecht, Soichi Watanabe, Wolfgang Wach, Thomas Rose
-
Publication number: 20190381196Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.Type: ApplicationFiled: August 30, 2019Publication date: December 19, 2019Inventors: Leopoldo DELLA CIANA, Norbert GRETZ, Rossana PERCIACCANTE, Federica RODEGHIERO, Stefania GERACI, Jiaguo HUANG, Zeneida HERRERA PÉREZ, Johannes PILL, Stefanie WEINFURTER
-
Patent number: 10441666Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.Type: GrantFiled: May 15, 2015Date of Patent: October 15, 2019Assignee: CYANAGEN S.R.L.Inventors: Leopoldo Della Ciana, Norbert Gretz, Rossana Perciaccante, Federica Rodeghiero, Stefania Geraci, Jiaguo Huang, Zeneida Herrera Pérez, Johannes Pill, Stefanie Weinfurter
-
Publication number: 20190261862Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.Type: ApplicationFiled: February 28, 2019Publication date: August 29, 2019Inventors: Ralf Heinrich, Johannes Pill, Sabine Neudecker, Daniel Schock-Kusch, Juergen Guenther, Stefan Koenig, Jochen Friedemann
-
Patent number: 10264977Abstract: Disclosed herein is a method for the transcutaneous determination of organ function in a subject. The method includes administering a fluorescent indicator substance to the subject, determining a first and a second concentration-time curve of the fluorescent indicator in a body fluid of the patient and fitting the concentration-time curves to a four compartment kinetic model.Type: GrantFiled: October 20, 2014Date of Patent: April 23, 2019Assignee: MediBeacon Inc.Inventors: Ralf Heinrich, Johannes Pill, Sabine Neudecker, Daniel Schock-Kusch, Juergen Guenther, Stefan Koenig, Jochen Friedmann
-
Publication number: 20180125407Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.Type: ApplicationFiled: January 3, 2018Publication date: May 10, 2018Inventors: Norbert Gretz, Johannes Pill, Daniel Schock-Kusch, Thomas Walter, Jürgen Hesser, Maliha Sadick, Felix Eickemeyer, Jae Hyung Hwang, Christian Schildknecht, Soichi Watanabe, Wolfgang Wach, Thomas Rose
-
Patent number: 9910007Abstract: A sensor device for detecting at least one analyte in a fluid, in particular in a body fluid, is disclosed. The sensor device includes at least one closed detector chamber and at least one electrical sensor having at least one sensor electrode. The detector chamber can be connected to the fluid in such a way that the analyte can penetrate into the detector chamber. The detector chamber includes at least one detector substance. The detector substance is designed to influence at least one electrical property of the electrical sensor, in particular at least one electrical property of the sensor electrode, depending on a concentration of the analyte in the detector chamber.Type: GrantFiled: November 22, 2013Date of Patent: March 6, 2018Assignee: ROCHE DIABETES CARE, INC.Inventors: Otto Fuerst, Johannes Pill, Bernd Roesicke
-
Publication number: 20170112425Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.Type: ApplicationFiled: September 16, 2016Publication date: April 27, 2017Inventors: Norbert Gretz, Johannes Pill, Daniel Schock-Kusch, Thomas Walter, Jürgen Hesser, Maliha Sadick, Felix Eickemeyer, Jae Hyung Hwang, Christian Schildknecht, Soichi Watanabe, Wolfgang Wach, Thomas Rose
-
Patent number: 9632094Abstract: A sensor plaster (116) for the transcutaneous measurement of an organ function, more particularly of a kidney function, is proposed. The sensor plaster (116) comprises at least one flexible carrier element (134) having at least one adhesive surface (138) which can be stuck onto a body surface. Furthermore, the sensor plaster (116) comprises at least one radiation source, more particularly a light source (142), wherein the radiation source is designed to irradiate the body surface with at least one interrogation light (162). Furthermore, the sensor plaster (116) comprises at least one detector (146) designed to detect at least one response light (176) incident from the direction of the body surface.Type: GrantFiled: August 20, 2009Date of Patent: April 25, 2017Assignee: Norbert GretzInventors: Norbert Gretz, Johannes Pill, Daniel Schock-Kusch, Thomas Walter, Jürgen Hesser, Maliha Sadick, Felix Eickemeyer, Jae Hyung Hwang, Christian Schildknecht, Soichi Watanabe, Wolfgang Wach, Thomas Rose
-
Publication number: 20160249808Abstract: The present invention relates to a method for determining an organ function in a subject, comprising the steps of: providing a first concentration-time curve obtained by transcutaneously measuring in a body fluid at a first position background fluorescence in at least one first time point and fluorescence of an indicator compound in at least a second, a third, a fourth, a fifth, and a sixth time point; providing a second concentration curve obtained by transcutaneously measuring in a body fluid at a second position background fluorescence in at least one seventh time point and fluorescence of an indicator compound in at least a eighth, a ninth, a tenth, an eleventh, and a twelfth time point; fitting the first and the second concentration curve into a kinetic model representing at least four diffusion compartments; and thereby determining an organ function in a subject.Type: ApplicationFiled: October 20, 2014Publication date: September 1, 2016Inventors: Ralf HEINRICH, Johannes PILL, Sabine NEUDECKER, Daniel SCHOCK-KUSCH, Jurgen GUNTHER, Stefan KONIG, Jochen FRIEDMANN
-
Publication number: 20150328342Abstract: The present invention relates to novel tricarbocyanine-cyclodextrin(s) conjugates useful as markers in the diagnosis of kidney diseases, a diagnostic composition comprising said conjugates, their use and their production.Type: ApplicationFiled: May 15, 2015Publication date: November 19, 2015Inventors: Leopoldo DELLA CIANA, Norbert GRETZ, Rossana PERCIACCANTE, Federica RODEGHIERO, Stefania GERACI, Jiaguo HUANG, Zeneida HERRERA PÉREZ, Johannes PILL, Stefanie WEINFURTER
-
Publication number: 20140083872Abstract: A sensor device for detecting at least one analyte in a fluid, in particular in a body fluid, is disclosed. The sensor device includes at least one closed detector chamber and at least one electrical sensor having at least one sensor electrode. The detector chamber can be connected to the fluid in such a way that the analyte can penetrate into the detector chamber. The detector chamber includes at least one detector substance. The detector substance is designed to influence at least one electrical property of the electrical sensor, in particular at least one electrical property of the sensor electrode, depending on a concentration of the analyte in the detector chamber.Type: ApplicationFiled: November 22, 2013Publication date: March 27, 2014Applicant: Roche Diagnostics Operations, Inc.Inventors: Otto Fuerst, Johannes Pill, Bernd Roesicke
-
Patent number: 8267949Abstract: An introducing device for introduction of a medical device into a body is described which has a distal region with a tip region for generating an opening in the skin, and a segment region which comprises at least two sections which, in a rigid state, are essentially rigidly connected at least to one another and to the distal region and which are movable relative to one another in a flexible state. Furthermore, a system is described in which a sensor is integrated into the device for introduction into a body.Type: GrantFiled: December 22, 2008Date of Patent: September 18, 2012Assignees: Roche Diagnostics International AG, Roche Diagnostics Operations, Inc.Inventors: Hans List, Otto Fuerst, Hans-Peter Haar, Ulrich Haueter, Herbert Harttig, Johannes Pill
-
Patent number: 8131474Abstract: The invention relates to a method for investigating the glucose metabolism of a human being for disease-relevant and/or disease-related particularities. The glucose concentration g(t1) to g(tn) of a body fluid is measured at time points t1 to tn that are distributed over a period of at least six hours. The data points are then determined in phase space coordinates from the glucose concentration measuring values g(t1) to g(tn). The data points are then processed to highlight disease-relevant and/or disease-related particularities of the glucose metabolism of the investigated human being. The processing of the data points can be implemented by plotting them in a phase space representation or by determining from the data points a disturbance parameter that is correlated to the severity of a disturbance of glucose metabolism.Type: GrantFiled: March 15, 2006Date of Patent: March 6, 2012Assignee: Roche Diagnostics Operations, Inc.Inventors: Arnulf Staib, Johannes Pill, Reinhard Kotulla, Reiner Hegger