Abstract: The present invention relates to mutants of S100A12 having at least one mutation in the high-affinity calcium binding hand or the low-affinity calcium binding hand or the zinc binding region. The present invention also relates to methods of detecting S100A12 dimers in a sample as well as methods of diagnosis using the S100A12 mutant of the invention, as well as to diagnostic compositions and kits comprising such an S100A12 mutant. The present invention further relates to a method of generating an antibody that specifically binds to an S100A12 dimer using the S100A12 mutant of the invention, as well as to an antibody that specifically binds to an S100A12 dimer.

Abstract: The present application provides for the use of S100A8 or S100A9 homodimer or S100A8/A9 heterodimer in the prevention or treatment of a NF-?B-associated postnatal inflammatory disorder in a newborn subject. Moreover, the present invention relates to a pharmaceutical composition comprising S100A8 or S100A9 homodimer or S100A8/A9 heterodimer and an in vitro method for evaluating the risk of a newborn subject for developing a NF-?B-associated postnatal inflammatory disorder.

Abstract: The present invention relates to a method of stratifying a subject having no symptoms of acute tonsillitis for tonsillectomy or tonsillotomy, to a method of diagnosing recurrent tonsillitis in a subject having no symptoms of acute tonsillitis and to a method of predicting the risk or the predisposition for recurrence of acute tonsillitis (RAT) in a subject having no symptoms of acute tonsillitis. These methods ae based on the determination of the biomarkers IL-1 ?, IL-18 and S100A8/S100A9 in said subject.

Abstract: A neutrino detector device (100) for detecting neutrinos comprises at least one target detector (10) including a target crystal (11) for creating phonons in response to an interaction of neutrinos to be detected with the target crystal (11) and a target temperature sensor (12) for sensing a temperature change in response to an absorption of phonons created in the target crystal (11), an inner veto detector (20) comprising at least one inner veto component (21) with an inner veto temperature sensor (23), wherein the at least one inner veto component (21) is adapted for supporting the at least one target detector (10) and for an anticoincidence based discrimination of alpha and beta background interaction events by creating phonons in response to the background interaction events and sensing a temperature change in response to an absorption of the phonons with the inner veto temperature sensor (23), and an outer veto detector (30) for accommodating the inner veto detector (20), wherein the outer veto detector (

Abstract: The present application provides for the use of S100A8 or S100A9 homodimer or S100A8/A9 heterodimer in the prevention or treatment of a NF-?B-associated postnatal inflammatory disorder in a newborn subject. Moreover, the present invention relates to a pharmaceutical composition comprising S100A8 or S100A9 homodimer or S100A8/A9 heterodimer and an in vitro method for evaluating the risk of a newborn subjectfor developing a NF-?B-associated postnatal inflammatory disorder.

Abstract: The present application provides quinoline-3-carboxamide compounds covalently linked to a label for use in the diagnosis of an inflammatory disease at local site. The above mentioned compounds can be used to detect or image accumulation of S100A9 in the body of a subject at sites of inflammation, using in vivo non-invasive molecular imaging techniques for the detection of said compounds. Accordingly, labeled quinoline-3-carboxamide compounds can be applied to evaluate the risk of a subject of developing an inflammatory disease and to follow the progress of the disease.

Abstract: The present invention relates to mutants of S100A12 having at least one mutation in the high-affinity calcium binding hand or the low-affinity calcium binding hand or the zinc binding region. The present invention also relates to methods of detecting S100A12 dimers in a sample as well as methods of diagnosis using the S100A12 mutant of the invention, as well as to diagnostic compositions and kits comprising such an S100A12 mutant. The present invention further relates to a method of generating an antibody that specifically binds to an S100A12 dimer using the S100A12 mutant of the invention, as well as to an antibody that specifically binds to an S100A12 dimer.

Abstract: This pick-up apparatus for picking up harvested root crop defines a pick-up plane and comprises a pick-up section. The pick-up section comprises a pick-up member adapted to pick up the root crop, and a cleaning member. The pick-up member defines a pick-up position with respect to the pick-up plane. The pick-up apparatus comprises a cleaning adjustment device adapted to adjust the position of the cleaning member between at least two cleaning positions, the cleaning positions being different one from another. In each of the cleaning positions of the cleaning member and while the pick-up member is in the pick-up position, the distance of the cleaning member with respect to the pick-up plane is different from the distance of the cleaning member with respect to the pick-up plane in the other cleaning position.

Abstract: The present invention relates to a compound for use in a method of diagnosing acute or chronic inflammatory diseases in a subject. In particular, the present invention provides a S100A8/S100A9 heterodimer standard comprising at least one mutation in low- or high-affinity calcium binding hand that can be used in a method of detecting biomarkers of inflammation in a sample. Accordingly, the S100A8/S100A9 heterodimer standard allows for standardizing quantitative immunoassays and quantifying S100A8/S100A9 heterodimers.

Abstract: The present application provides quinoline-3-carboxamide compounds covalently linked to a label for use in the diagnosis of an inflammatory disease at local site. The above mentioned compounds can be used to detect or image accumulation of S100A9 in the body of a subject at sites of inflammation, using in vivo non-invasive molecular imaging techniques for the detection of said compounds. Accordingly, labeled quinoline-3-carboxamide compounds can be applied to evaluate the risk of a subject of developing an inflammatory disease and to follow the progress of the disease.

Abstract: A semiconductor device comprising a substrate and an electronic circuit thereon is described. The electronic circuit comprises a first voltage provider node, a second voltage provider node, and an intermediary node connected to the first and second voltage provider node by a first and second network with a first and second resistance, respectively. The substrate is susceptible to conducting a substrate current. The semiconductor device further comprises a substrate current sensor. The first network is arranged to reduce the first resistance in response to the substrate current sensor signaling an increase of the substrate current and vice versa. Similarly, the second network is arranged to reduce the second resistance in response to the substrate current sensor signaling an increase of the substrate current and vice versa. A method of operating a semiconductor device is also disclosed.

Abstract: This pick-up apparatus for picking up harvested root crop defines a pick-up plane PP and comprises a pick-up section. The pick-up section comprises a pick-up member adapted to pick up the root crop, and a cleaning member. The pick-up member defines a pick-up position with respect to the pick-up plane PP. The pick-up apparatus comprises a cleaning adjustment device adapted to adjust the position of the cleaning member between at least two cleaning positions, the cleaning positions being different one from another. In each of the cleaning positions of the cleaning member and while the pick-up member is in the pick-up position, the distance DC1 of the cleaning member with respect to the pick-up plane PP is different from the distance DC2 of the cleaning member with respect to the pick-up plane PP in the other cleaning position.

Abstract: Provided is an isolated peptide or a peptidomimetic comprising a sequence corresponding to amino acid positions 431-616 or 411-616 of the human protein TLR4 or corresponding to amino acid positions 84-131 of the human protein MD-2. Provided is also an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 411 to 616 of variant 1 the human protein TLR4. Provided is further an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 86 to 131 of the human protein MD2. Provided is further the use of such antibody in the treatment or diagnosis of an inflammatory disorder. Also provided is an in-vitro method of identifying a compound capable of inhibiting the formation of a complex between one of the above peptides or whole molecules and an S100A8 or S100A9 or S100A8/S100A9 protein or a functional fragment thereof.

Abstract: A semiconductor device, comprising a substrate and an electronic circuit formed thereon is described. The substrate is susceptible to conducting a substrate current. The semiconductor device further comprises a substrate current sensor, which comprises a sensing line for sensing the potential at a charge collecting region; a supply node; and a current source connected between the supply node and the charge collecting region. The current source is arranged to inject a stationary current into the charge collecting region when the potential at the charge collecting region is below the supply potential. The sensing line comprises a monoflop, which is arranged to assume an unstable state when the potential at its input has exceeded a threshold and to return to a stable state when the potential at its input has remained below the threshold for at least a time period.

Abstract: A semiconductor device comprising a substrate and an electronic circuit thereon is described. The electronic circuit comprises a first voltage provider node, a second voltage provider node, and an intermediary node connected to the first and second voltage provider node by a first and second network with a first and second resistance, respectively. The substrate is susceptible to conducting a substrate current. The semiconductor device further comprises a substrate current sensor. The first network is arranged to reduce the first resistance in response to the substrate current sensor signaling an increase of the substrate current and vice versa. Similarly, the second network is arranged to reduce the second resistance in response to the substrate current sensor signaling an increase of the substrate current and vice versa. A method of operating a semiconductor device is also disclosed.

Abstract: Provided is an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 63-79 or 73-85 of the human protein S100A9. Provided is further an antibody with a specificity to an epitope that is a region corresponding to amino acid positions 55-71 of the human protein S100A8. Provided is further the use of such antibody in the treatment or diagnosis of an inflammatory disorder. Also provided is an in-vitro method of identifying a compound capable of inhibiting the formation of a complex between a peptide corresponding to one of the above epitopes of S100A9 or the above epitope of S100A8 and a TLR4 receptor, where a compound suspected to affect the complex formation is contacted with the peptide and the TLR4 receptor.

Abstract: The present invention relates to a pharmaceutical composition comprising glucocorticoid (GC)-induced human monocytes, and optionally a pharmaceutically acceptable carrier.

Abstract: The invention relates to a large-format scanning system (1) comprising at least two image acquisition elements (2) in a cascade arrangement, at least one platen, preferably a glass plate (3), arranged upstream thereof, and at least two reflector rolls (5) arranged opposite the at least two image acquisition elements (2) in a cascade arrangement, said reflector rolls being pressed against the glass plate (3) and/or a copy (4) to be scanned by means of resilient elements (6) that are arranged at the sides of the reflector rolls (5). According to the invention, the side portions (7) of the reflector rolls (5) are designed such that they touch the glass plate (3) only outside the reading area of the image acquisition elements (2) for the copy to be scanned (4) and that the copy to be scanned (4) rests on the glass plate (3) in the center area (8) of the reflector rolls (5).

Abstract: The invention relates to a large-format scanning system (1) comprising at least two image acquisition elements (2) in a cascade arrangement, at least one platen, preferably a glass plate (3), arranged upstream thereof, and at least two reflector rolls (5) arranged opposite the at least two image acquisition elements (2) in a cascade arrangement, said reflector rolls being pressed against the glass plate (3) and/or a copy (4) to be scanned by means of resilient elements (6) that are arranged at the sides of the reflector rolls (5). According to the invention, the side portions (7) of the reflector rolls (5) are designed such that they touch the glass plate (3) only outside the reading area of the image acquisition elements (2) for the copy to be scanned (4) and that the copy to be scanned (4) rests on the glass plate (3) in the center area (8) of the reflector rolls (5).

Abstract: The present invention relates to a pharmaceutical composition comprising glucocorticoid (GC)-induced human monocytes, and optionally a pharmaceutically acceptable carrier.