Patents by Inventor Johannes Schoemaker

Johannes Schoemaker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Piperidine derivatives, their preparation and their application in therapy
    Patent number: 5434169
    Abstract: A compound which is a piperidine derivative of formula (I) ##STR1## in which R represents hydrogen, or unbranched or branched C.sub.1 -C.sub.6 alkyl group; andAr represents phenyl optionally substituted with one or more radicals selected from the halogens, amino, C.sub.1 -C.sub.2 alkoxy and (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.2)alkoxy, or a heteroaryl group;or a pharmaceutically acceptable acid addition salt thereof;provided that when R is hydrogen Ar is not phenyl or 4 -chlorophenyl.The compounds are useful in therapy as ligands for 5-HT.sub.3 and 5-HT.sub.4 receptors.
    Type: Grant
    Filed: September 27, 1993
    Date of Patent: July 18, 1995
    Assignee: Synthelabo
    Inventors: Samir Jegham, Itzchak Angel, Thomas Purcell, Johannes Schoemaker
  • Piperidine derivatives, their preparation and their therapeutic application
    Patent number: 5280030
    Abstract: A compound which is a piperidine derivative of general formula (I) ##STR1## in which R.sub.1 represents a hydrogen atom, a linear or branched (C.sub.1-6)alkyl group or a cyclo(C.sub.3-8)alkyl group, X represents an oxygen atom, a sulphur atom or a group of general formula N--R.sub.3 in which R.sub.3 is a hydrogen atom, or a linear or branched (C.sub.1-8)alkyl, cyclo(C.sub.3-6)alkyl, cyclo(C.sub.3-6)alkylmethyl, (C.sub.1-4)alkoxy-(C.sub.1-4)alkyl, phenyl, pyridin-4-yl, pyridin-3-yl, pyridin-4-ylmethyl or pyridin-3-ylmethyl group and Z represents a hydrogen or fluorine atom and acid addition salts thereof with pharmaceutically acceptable acids, can be used for the treatment and prevention of disorders in which 5-HT receptors are involved.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: January 18, 1994
    Assignee: Synthelabo
    Inventors: Samir Jegham, Gerard DeFosse, Thomas Purcell, Johannes Schoemaker
  • Method of treatment of psychotic disorders
    Patent number: 5023266
    Abstract: Ifenprodil and its analogues are useful for the treatment of psychoses such as schizophrenia.
    Type: Grant
    Filed: January 24, 1990
    Date of Patent: June 11, 1991
    Assignee: Synthelabo
    Inventors: Salomon Z. Langer, Jonathan R. Frost, Johannes Schoemaker, Bernard Gaudilliere, Jean Bertin, Jean Rousseau, Regis Dupont, Alexander E. Wick