Patents by Inventor Johannes Sombroek

Johannes Sombroek has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazopyridines
    Patent number: 6037349
    Abstract: Imidazopyridine derivatives ad pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: January 4, 1999
    Date of Patent: March 14, 2000
    Assignee: Merck Patent GmbH
    Inventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Imidazopyridines
    Patent number: 5798364
    Abstract: Imidazopyridine derivatives and pharmacologically acceptable salts having antagonistic properties towards angiotensin II can be used for the treatment of hypertension, aldosteronism and cardiac insufficiency.
    Type: Grant
    Filed: October 4, 1996
    Date of Patent: August 25, 1998
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Werner Mederski, Johannes Sombroek, Pierre Schelling, Norbert Beier, Ingeborg Lues, Klaus-Otto Minck
  • Peptide analogues
    Patent number: 5401722
    Abstract: New peptide analogues of the formula IR.sup.1 --Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CH.sub.2).sub.o --(CR.sup.5).sub.t --(CH.sub.2).sub.v --CE--C.sub.w H.sub.2w --R.sup.6 Iin which R.sup.1 to R.sup.6 Z, E, o, t and w have the meanings described herein, and the salts thereof, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: February 15, 1991
    Date of Patent: March 28, 1995
    Inventors: Horst Juraszyk, Peter Raddatz, Johannes Sombroek, Claus J. Schmitges, Klaus-Otto Minck
  • Amino acid derivatives
    Patent number: 5378691
    Abstract: New amino acid derivatives of the formula IR.sup.1 --C.sub.p H.sub.2p --(NH).sub.y --CO--NH--CHR.sup.2 --CO--Z--C.sub.m H.sub.2m --CO--NH--CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--Q--Y Iin which R.sup.1 to R.sup.5, p, y, Z, m, n, E, Q and Y have the meanings defined herein, and the salts thereof, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: January 3, 1995
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Peter Raddatz, Joachim Gante, Johannes Sombroek, Claus J. Schmitges, Klaus-Otto Minck
  • Aminoacid derivatives inhibiting renin
    Patent number: 5215967
    Abstract: New amino acid derivatives of the formulaR.sup.1 --Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.a --CO--E--Q--Ywherein R.sup.1 to R.sup.5, a, Z, E, Q and Y have the meanings defined herein, and salts thereof inhibit the activity of human plasma renin.
    Type: Grant
    Filed: November 30, 1989
    Date of Patent: June 1, 1993
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Joachim Gante, Peter Raddatz, Johannes Sombroek, Claus J. Schmitges, Klaus O. Minck
  • Peptide and renin inhibitors
    Patent number: 5215966
    Abstract: Novel amino acid derivatives of the formula IX--Z--NH--CHR.sup.1 --CO--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--W'--Ywherein X, Z, R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, W', Y and n have the meanings defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: November 27, 1987
    Date of Patent: June 1, 1993
    Assignee: Merck Patent Gesellschaft mit Beschrankter Haftung
    Inventors: Gunter Holzemann, Peter Raddatz, Claus J. Schmitges, Klaus Otto Minck, Alfred Jonczyk, Johannes Sombroek, Joachim Gante
  • Amino acid derivatives
    Patent number: 4829053
    Abstract: New aminoacid derivatives of the formula IX--Z--NR.sup.2 --CHR.sup.3 --CR.sup.4 --(CHR.sup.5).sub.n --CO--E--NR.sup.6 --(CHR.sup.7).sub.s --D Iwherein X, Z, R.sup.2, R.sup.3, R.sup.4, R.sup.5, E, R.sup.6, R.sup.7, D, n and s have the meanings defined herein and their salts, inhibit the activity of human plasma renin.
    Type: Grant
    Filed: July 31, 1987
    Date of Patent: May 9, 1989
    Assignee: Merck Patent Gesellschaft Mit Beschrankter Haftung
    Inventors: Peter Raddatz, Joachim Gante, Claus J. Schmitges, Klaus Otto Minck, Johannes Sombroek, Gunter Holzemann
  • Statine-containing peptides useful in medicaments
    Patent number: 4755592
    Abstract: New peptides of the formula IX--Z--W--E--W'--Y Iwherein X, Z, W, E, W' and Y are as defined herein and their salts inhibit the activity of human plasma renin.
    Type: Grant
    Filed: April 3, 1986
    Date of Patent: July 5, 1988
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Peter Raddatz, Gunter Holzemann, Alfred Jonczyk, Claus J. Schmitges, Klaus-Otto Minck, Hans-Eckart Radunz, Johannes Sombroek
  • 1-Aryloxy-3-nitratoalkylamino-2-propanols and use as .beta.-receptor blocker
    Patent number: 4288452
    Abstract: Compounds of the formulaAr--O--CH.sub.2 --CHOH--CH.sub.2 --NH--RwhereinAr is phenyl; phenyl monosubstituted or polysubstituted by halogen, cyano, acylamino (in which the acyl group has 1-7 carbon atoms), alkanoyl of 1-4 carbon atoms, alkyl (in which the chain can be interrupted by 1 or 2 oxygen atoms or by one sulfur atom and/or in which a multiple bond can be present) of a total of 1-10 carbon atoms, cycloalkyl of 3-8 carbon atoms, and/or cycloalkoxy of 3-8 carbon atoms; naphthyl; indanyl; indenyl; tetralyl; indolyl; indolyl monosubstituted or polysubstituted by alkyl, each of 1-4 carbon atoms; carbazolyl; or 1,2,3,4-tetrahydro-2-oxoquinolyl; andR is nitratoalkyl of 2-10 carbon atoms,and the physiologically acceptable acid addition salts thereof have valuable pharmacological properties, e.g., which make them useful for prophylaxis and treatment of heart problems, e.g., as .beta.-receptor blockers.
    Type: Grant
    Filed: February 9, 1979
    Date of Patent: September 8, 1981
    Assignee: Merck Patent Gesellschaft mit beschrankter Haftung
    Inventors: Johannes Sombroek, Karl-Heinz Becker, Klaus O. Minck, Hans-Joachim Enenkel