Patents by Inventor Johannes Streffer

Johannes Streffer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of identifying genetic risk for and evaluating treatment of alzheimer's disease by determining single nucleotide polymorphisms
    Publication number: 20050177881
    Abstract: Based on the unexpected identification of single nucleotide polymorphisms in the LIPA gene as novel genetic risk factors that link cholesterol metabolism to Alzheimer's disease, the present invention provides a method of diagnosing or prognosticating Alzheimer's disease, or determining the propensity or predisposition of a subject to develop Alzheimer's disease. The method comprises detecting the presence or absence of a variation in the LIPA gene which encodes the enzyme acid cholesteryl ester hydrolase. Furthermore, the invention provides methods of diagnosing Alzheimer's disease by using the CH25H gene and/or the LIPA gene and their corresponding gene products.
    Type: Application
    Filed: December 3, 2002
    Publication date: August 11, 2005
    Inventors: Andreas Papassotiropoulos, Johannes Streffer, Christoph Hock, Roger Nitsch
  • Methods of identifying genetic risk for and evaluating treatment of alzheimer's disease by determining cyp46 genotype
    Publication number: 20050048492
    Abstract: Based on the unexpected identification of a CYP46 gene polymorphism as a novel genetic risk factor that links cholesterol metabolism to Alzheimer's disease, the present invention provides a method of diagnosing or prognosticating Alzheimer's disease, or determining the propensity or predisposition of a subject to develop Alzheimer's disease. The method comprises detecting the presence or absence of a variation in the CYP46 gene which encodes the enzyme cholesterol 24-hydroxylase.
    Type: Application
    Filed: March 1, 2002
    Publication date: March 3, 2005
    Inventors: Andreas Papassotiropoulos, Johannes Streffer, Roger Nitsch, Christoph Hock