Patents by Inventor Johannes Tommassen

Johannes Tommassen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Vaccine
    Publication number: 20070031449
    Abstract: The present invention discloses a Gram negative bacterium in which the expression of a protein involved in LPS transport to the outer membrane is functionally downregulated such that the level of LPS in the outer membrane is decreased compared to a wild-type Gram negative bacterium. Down regulation of Imp and MsbA proteins can result in such a bacterium. Outer membrane vesicle preparations derived from the Gram negative bacterium of the invention can be used in vaccines to provide protection against bacterial infection.
    Type: Application
    Filed: December 21, 2004
    Publication date: February 8, 2007
    Inventors: Martine Bos, Jan Poolman, Boris Tefsen, Johannes Tommassen
  • Neisseria meningitidis antigenic polypeptides, corresponding polynucleotides and protective antibodies
    Publication number: 20060189792
    Abstract: The invention provides (Neisseria meningitidis) BASB030 polypeptides and polynucleotides encoding BASB030 polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are antibodies, diagnostic, prophylactic and therapeutic uses thereof.
    Type: Application
    Filed: August 18, 2005
    Publication date: August 24, 2006
    Inventors: Jean-Louis Ruelle, Johannes Tommassen
  • Mutant protein and refolding method
    Publication number: 20060141563
    Abstract: An FrpB protein having one or more deletions of non-conserved amino acids compared to a corresponding wild-type FrpB protein, and a method of refolding an FrpB protein.
    Type: Application
    Filed: August 28, 2003
    Publication date: June 29, 2006
    Inventors: Ralph Biemans, Philippe Denoel, Christiane Feron, Karine Larine Goraj, Jeroen Kortekaas, Jan Poolman, Johannes Tommassen, Vincent Weynants