Patents by Inventor Johannes Van Der Loo

Johannes Van Der Loo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11066678
    Abstract: The invention relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using eukaryotic cells.
    Type: Grant
    Filed: July 18, 2014
    Date of Patent: July 20, 2021
    Assignee: Children's Hospital Medical Center
    Inventors: Johannes Van Der Loo, Punam Malik
  • Patent number: 9551010
    Abstract: The invention relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using eukaryotic cells.
    Type: Grant
    Filed: July 19, 2013
    Date of Patent: January 24, 2017
    Assignee: Children's Hospital Medical Center
    Inventors: Johannes Van der Loo, Lilith Reeves
  • Publication number: 20160168590
    Abstract: The invention relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using eukaryotic cells. A method of improving viral titer in a transfectionbased production system using a eukaryotic cell is provided. The method can include at least one of: harvesting a confluent population of eukaryotic cells that have progressed beyond log phase of cell growth for at least 24 hours prior to transfection; transfecting the cells by mixing the population with transfection reagents and plasmid DNA at the time of re-seeding the cells into a culture vessel, where the harvesting and transfecting steps, alone or in combination, results in an improved viral titer, by at least 2-fold, in a transfectionbased production using a eukaryotic cell.
    Type: Application
    Filed: July 18, 2014
    Publication date: June 16, 2016
    Inventors: Johannes VAN DER LOO, Punam MALIK
  • Publication number: 20130302898
    Abstract: The invention relates to methods of improving titer in transfection-based bioreactor culture production or transfection-based production systems using eukaryotic cells.
    Type: Application
    Filed: July 19, 2013
    Publication date: November 14, 2013
    Inventors: Johannes Van der Loo, Lilith Reeves
  • Patent number: 8348809
    Abstract: System for training optimisation, the system comprising: at least one sensor for measuring a mechanical load parameter which is indicative for a mechanical load of the training a storage module for storing data which are dispatched by the least one sensor in a log file; a training advice module which is arranged for determining a personal training advice related to a load assessment of the user based on at least the data stored in the log file, the data comprising a cumulative load parameter or a training load history determined on the basis of historical sensor data stored in the log file, the training advice comprising the frequency of next training sessions and/or a type of training to be performed in the next training session; at least one output device such as a display, a sound signal, audio output, voice output or a vibrating element for outputting said training advice to said user.
    Type: Grant
    Filed: September 4, 2007
    Date of Patent: January 8, 2013
    Assignee: Nederlandse organisatie voor toegepast-natuurwetenschappelijk onderzoek TNO
    Inventors: Marc Esse van der Zande, Johannes van der Loo, Sytze Kalisvaart
  • Patent number: 8095208
    Abstract: System for effective training heart rate zone determination, the system comprising:—a training module adapted to determine target training heart rate zone based on at least one stored parameter;—at least one sensor for measuring core temperature of a user's body during training;—at least one sensor for measuring a user's heart rate during training;—a compensation module, which is arranged for compensating the target training heart rate zone based on said core temperature;—an indicating module adapted to compare the users heart rate to an effective training heart rate zone based on information from the compensation module and to inform the user when the heart rate exceeds or drops under the effective training heart rate zone. The invention further relates to use of such a system.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: January 10, 2012
    Assignee: Nederlandse Organisatie Voor Toegepast-Natuurwetenschappelijk Onderzoek TNO
    Inventor: Johannes Van Der Loo
  • Publication number: 20100076278
    Abstract: System for training optimisation, the system comprising: at least one sensor for measuring a mechanical load parameter which is indicative for a mechanical load of the training a storage module for storing data which are dispatched by the least one sensor in a log file; a training advice module which is arranged for determining a personal training advice related to a load assessment of the user based on at least the data stored in the log file, the data comprising a cumulative load parameter or a training load history determined on the basis of historical sensor data stored in the log file, the training advice comprising the frequency of next training sessions and/or a type of training to be performed in the next training session; at least one output device such as a display, a sound signal, audio output, voice output or a vibrating element for outputting said training advice to said user.
    Type: Application
    Filed: September 4, 2007
    Publication date: March 25, 2010
    Applicant: Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO
    Inventors: Marc Esse van der Zande, Johannes van der Loo, Sytze Kalisvaart
  • Publication number: 20090253992
    Abstract: System for effective training heart rate zone determination, the system comprising: -a training module adapted to determine target training heart rate zone based on at least one stored parameter; -at least one sensor for measuring core temperature of a user's body during training; -at least one sensor for measuring a user's heart rate during training; -a compensation module, which is arranged for compensating the target training heart rate zone based on said core temperature; -an indicating module adapted to compare the users heart rate to an effective training heart rate zone based on information from the compensation module and to inform the user when the heart rate exceeds or drops under the effective training heart rate zone. The invention further relates to use of such a system.
    Type: Application
    Filed: July 5, 2007
    Publication date: October 8, 2009
    Applicant: Nederlandse Organisatie voor toegepast- natuurwetenschappelijk Onderzoek TNO
    Inventor: Johannes Van Der Loo