Patents by Inventor Johannes Winkelmann

Johannes Winkelmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4705802
    Abstract: The invention relates to new .omega.-aryl-alkylthienyl compounds having the Formula I ##STR1## i.e. omega-aryl-alkyl thienyl alkanoic acids and, respectively, omega-aryl-alkyl thienyl alkenoic acids, the alkali metal salts of such acids and certain esters thereof. The invention further relates to processes for the treatment of chronically inflammatory processes in humans.
    Type: Grant
    Filed: February 26, 1985
    Date of Patent: November 10, 1987
    Assignee: A. Nattermann & CIE GmbH
    Inventors: Hans-Heiner Lautenschlager, Michael J. Parnham, Sigurd Leyck, Johannes Winkelmann, Axel Brekle
  • Patent number: 4505854
    Abstract: The invention relates to the new optically active dipeptide D-2-phenylglycyl-D-2-phenylglycine and its pharmacologically acceptable salts or acid addition salts and the use thereof as tissue dissolving and histolytic agent.
    Type: Grant
    Filed: January 5, 1984
    Date of Patent: March 19, 1985
    Assignee: Nattermann & Cie GmbH
    Inventors: Jurgen Biedermann, Eugen Etschenberg, Hugo Friehe, Wolfgang Scheef, Johannes Winkelmann
  • Patent number: 4460598
    Abstract: The invention relates to new triphenylimidazolyloxyalkanoic acids of the general formula I ##STR1## and a process for the treatment of thromboembolic, inflammatory and/or atherosclerotic diseases in humans by using the same.
    Type: Grant
    Filed: July 25, 1983
    Date of Patent: July 17, 1984
    Assignee: A. Nattermann & Cie GMBH
    Inventors: Hans-Heiner Lautenschlager, Andre Welter, Gerd Hilboll, Johannes Winkelmann, Gerrit Prop, Axel Brekle, Ottfried Zierenberg
  • Patent number: 4358442
    Abstract: The present invention is directed to a new rosmarinic acid-phospholipide-complex product containing rosmarinic acid and the phospholipide in a molar ratio of 1:2. The invention is further directed to a process for producing the same and to pharmaceutical preparations containing the same.
    Type: Grant
    Filed: December 11, 1980
    Date of Patent: November 9, 1982
    Assignee: Nattermann & Cie GmbH
    Inventors: Ferdinand Wirtz-Peitz, Manfred Probst, Johannes Winkelmann
  • Patent number: 4352799
    Abstract: The present invention is related to pharmaceutical preparations containing as active components the known compound 2-phenyl-1.2-benzisoselenazol-3(2H)-one containing pharmaceutical preparations and process for the treatment in particular of rheumatic diseases.
    Type: Grant
    Filed: July 9, 1981
    Date of Patent: October 5, 1982
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Marcel Renson, Eugen Etschenberg, Johannes Winkelmann
  • Patent number: 4349686
    Abstract: The present invention refers to new 5-(N-Alkyl-N-acyl-amino)-thiophen-2-carboxylic acid derivatives having the general formula I ##STR1##
    Type: Grant
    Filed: November 12, 1981
    Date of Patent: September 14, 1982
    Assignee: A. Nattermann & Cie GmbH
    Inventors: Hans-Heiner Lautenschlager, Hans Betzing, Johannes Winkelmann, Manfred Probst, Brigitte Stoll
  • Patent number: 4309407
    Abstract: The invention provides novel .omega.-(5-alkenylthien-2-yl)alkanecarboxylic acids and their functional derivatives having the formula ##STR1## wherein n is an integer from 1 to 9, inclusive; R.sup.1 is H and R.sup.2 is --OH, or R.sup.1 and R.sup.2 together with the wavy lines represent a keto group; and R.sup.3 is H, C.sub.1 -C.sub.6 straight or branched-chain saturated hydrocarbon, or a pharmaceutically acceptable alkali cation. The 3-oxoalkenyl-substituted compounds of formula (I) are prepared by a Wittig-Horner reaction using a 2-oxoheptylphosphonic acid dialkyl ester and an aldehyde of the formula ##STR2## as starting materials, while the 3-hydroxyalkenyl-substituted compounds are obtained by reduction of the corresponding 3-oxoalkenyl compounds. The esters of formula (I) can also be readily converted to the corresponding acids and salts of formula (I).
    Type: Grant
    Filed: November 12, 1980
    Date of Patent: January 5, 1982
    Assignee: A. Nattermann & Cie. GmbH
    Inventors: Hans-Heiner Lautenschlager, Hans Betzing, Johannes Winkelmann, Manfred Probst