Abstract: An antenna arrangement (1), for use within a full-duplex communication channel. The antenna arrangement (1) having at least a first planar receiving antenna (4) and a transmitting antenna group with a first planar transmitting antenna (2) and a second planar transmitting antenna (3). The transmitting antennas (2, 3) and the first receiving antenna (4) are arranged with their respective main surfaces (6) parallel to a common base surface (7) around a common center of rotation (Z), wherein the planar transmitting antennas (2, 3) are arranged rotated 180° to one another around the center of rotation (Z). The first receiving antenna (4) has the same center-to-center distance (D) to both transmitting antennas (2, 3).

Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).

Abstract: An antenna arrangement (1) for use within a full-duplex communication channel, comprising at least a first planar receiving antenna (4) and a transmitting antenna group with a first planar transmitting antenna (2) and a second planar transmitting antenna (3). The transmitting antennas (2, 3) and the first receiving antenna (4) are arranged with their respective main surfaces (6) parallel to a common base surface (7) around a common center of rotation (Z), wherein the transmitting antennas (2, 3) are arranged rotated 180° to one another around the center of rotation (Z). The first receiving antenna (4) has the same center-to-center distance (D) to both transmitting antennas (2, 3).

Abstract: An antenna arrangement (1) for use within a full-duplex communication channel, comprising at least a first planar receiving antenna (4) and a transmitting antenna group with a first planar transmitting antenna (2) and a second planar transmitting antenna (3). The transmitting antennas (2, 3) and the first receiving antenna (4) are arranged with their respective main surfaces (6) parallel to a common base surface (7) around a common center of rotation (Z), wherein the transmitting antennas (2, 3) are arranged rotated 180° to one another around the center of rotation (Z). The first receiving antenna (4) has the same center-to-center distance (D) to both transmitting antennas (2, 3).

Abstract: An electric drive axle of a vehicle with a parking lock and with at least one electric drive with a drive gear of a drive shaft. The drive gear is coupled via at least one intermediate gear of an intermediate shaft to an output gear of a differential gear unit for driving at least one output shaft. For decoupling the electric drive, at least one claw shift element is associated with the drive shaft and/or with the intermediate shaft in such a way that the claw shift element is arranged upstream of the parking lock in power flow direction from electric drive to differential gear unit.

Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).

Abstract: The present invention relates to a circuit for switching an AC voltage. It contains an input terminal able to be connected to an AC voltage source, an output terminal able to be connected to a load impedance, and a first series circuit. This series circuit comprises a diode and a circuit for storing electrical charges. The series circuit has a first end connection that is connected to the input terminal and a second end connection that is connected to the output terminal. The circuit for switching an AC voltage furthermore contains a DC voltage source, which is connected to an electrical connection between the diode and the input terminal or to an electrical connection between the diode and the output terminal and is designed to impress a DC current in the diode. The circuit for switching an AC voltage finally contains a first switch that is connected to an electrical connection between the diode and the circuit for storing electrical charges at one terminal.

Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g, purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).

Abstract: An electric drive axle of a vehicle with a parking lock and with at least one electric drive with a drive gear of a drive shaft. The drive gear is coupled via at least one intermediate gear of an intermediate shaft to an output gear of a differential gear unit for driving at least one output shaft. For decoupling the electric drive, at least one claw shift element is associated with the drive shaft and/or with the intermediate shaft in such a way that the claw shift element is arranged upstream of the parking lock in power flow direction from electric drive to differential gear unit.

Abstract: The present invention relates to a circuit for switching an AC voltage. It contains an input terminal able to be connected to an AC voltage source, an output terminal able to be connected to a load impedance, and a first series circuit. This series circuit comprises a diode and a circuit for storing electrical charges. The series circuit has a first end connection that is connected to the input terminal and a second end connection that is connected to the output terminal. The circuit for switching an AC voltage furthermore contains a DC voltage source, which is connected to an electrical connection between the diode and the input terminal or to an electrical connection between the diode and the output terminal and is designed to impress a DC current in the diode. The circuit for switching an AC voltage finally contains a first switch that is connected to an electrical connection between the diode and the circuit for storing electrical charges at one terminal.

Abstract: Embodiments of an electrical plug may include an electrical circuit having an input-side interface with at least one input-side contact point for connecting at least one signal conductor of at least one electrical lead. In some embodiments the electrical circuit has an output-side interface with at least one output-side contact point. The electrical circuit may have a transmission option from the input-side interface to the output-side interface for controlling impedance, and the design of the input-side interface in some embodiments may differ from the design of the output-side interface.

Abstract: An embodiment of a plug system having an electrical plug for connecting at least one electrical lead and having an electrical circuit. In certain embodiments, the electrical may have: at least one input-side contact which can be electrically connected to a signal conductor of the electrical lead; at least one output-side contact which can be electrically connected to an inner conductor of the plug; means for shielding which can be electrically connected to an earth conductor of the at least one electrical lead; a receptacle for the electrical circuit; and a closure element for closing an access opening of the receptacle. In some embodiments, the electrical circuit has contact points for contacting at least one input-side contact and at least one output-side contact when the electrical circuit is in the receptacle. The electrical circuit may have a transmission option for transmission from at least one input-side contact to at least one output-side contact.

Abstract: An embodiment of a plug system having an electrical plug for connecting at least one electrical lead and having an electrical circuit. In certain embodiments, the electrical may have: at least one input-side contact which can be electrically connected to a signal conductor of the electrical lead; at least one output-side contact which can be electrically connected to an inner conductor of the plug; means for shielding which can be electrically connected to an earth conductor of the at least one electrical lead; a receptacle for the electrical circuit; and a closure element for closing an access opening of the receptacle. In some embodiments, the electrical circuit has contact points for contacting at least one input-side contact and at least one output-side contact when the electrical circuit is in the receptacle. The electrical circuit may have a transmission option for transmission from at least one input-side contact to at least one output-side contact .

Abstract: Embodiments of an electrical plug may include an electrical circuit having an input-side interface with at least one input-side contact point for connecting at least one signal conductor of at least one electrical lead. In some embodiments the electrical circuit has an output-side interface with at least one output-side contact point. The electrical circuit may have a transmission option from the input-side interface to the output-side interface for controlling impedance, and the design of the input-side interface in some embodiments may differ from the design of the output-side interface.

Abstract: An axially actuatable positive engagement clutch which includes an input shaft with an input toothing and an output shaft with an output toothing. An axially displaceable connection element can occupy a meshing position which is located in an actuation path (s) between the open position and the closed position and in which the driving toothing engages with the input toothing or the output toothing for the first time during the transition from the open position into the closed position. An actuation device is configured to displace the connection element from the closed position to the open position, and an elastic return element which applies a restoring force to the connection element in direction of the closed position. The return element has a force/deflection characteristic with a local force maximum (F1) which coincides in the actuation path (s) at least approximately with the meshing position of the connection element.

Abstract: The present invention relates to a choke with two coils and a core for interleaved applications in step-up or step-down circuits or power factor compensation circuits. The core comprises several core sections with several lateral legs and a middle leg, whereby the core is designed such, that a coupling factor k of the two coils is smaller than 3%-5%. Furthermore, the core is designed such, that the core section form two loops with the middle leg as a common section, whereby each of the two coils lies on different loops outside of the common section. The lateral legs have a cross section A1 and the middle leg for the common section has a cross section A2<2×A1.

Abstract: An axially actuatable positive engagement clutch which includes an input shaft with an input toothing and an output shaft with an output toothing. An axially displaceable connection element can occupy a meshing position which is located in an actuation path (s) between the open position and the closed position and in which the driving toothing engages with the input toothing or the output toothing for the first time during the transition from the open position into the closed position. An actuation device is configured to displace the connection element from the closed position to the open position, and an elastic return element which applies a restoring force to the connection element in direction of the closed position. The return element has a force/deflection characteristic with a local force maximum (F1) which coincides in the actuation path (s) at least approximately with the meshing position of the connection element.

Abstract: The invention relates to an antisense or siRNA oligonucleotide or conjugate with improved pharmacokinetic properties, methods of producing the same as well as the use of such compounds and conjugates, e.g. as pharmaceutical composition, a pharmaceutical kit, a medicament or a tool in biomedical research. The conjugates of the invention have the formula I being P-(L-S—S—Y—X)n, wherein P represents a natural, artificial and/or modified oligonucleotide, L represents a linker group attached to one or more nucleosides at any position within the oligonucleotides sequence; S represents sulfur; X represents a ligand; Y represents a spacer and n is an integer ranging from 1 to the oligonucleotide length of P.

Abstract: The present disclosure relates to methods for selectively reducing CysL97 in a preparation of IL-17 antibodies or antigen binding fragments thereof (e.g., a preparation of secukinumab antibodies) that have been recombinantly produced by mammalian cells. Also provided are purified preparations of IL-17 antibodies or antigen binding fragments thereof produced by such methods, e.g., purified preparations of secukinumab, wherein the level of intact IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 90%, as measured by sodium dodecyl sulfate capillary electrophoresis (CE-SDS), and wherein the level of activity of IL-17 antibodies or antigen binding fragments thereof (e.g., secukinumab) in the preparation is high, e.g., at least about 92%, as measured by cation exchange chromatograph (CEX).

Abstract: A rod-shaped magnetic core element, having a first end with a spherical or cylindrical recess or a spherical or cylindrical connecting protrusion, and a second end with a spherical or cylindrical recess or a spherical or cylindrical connecting protrusion so that a bent connection of at least two magnetic core elements is variably adjustable. Magnetic core elements comprising spherical or cylindrical magnetic core ends of this type allow a nearly gap-free construction with little magnetic leakage due to slightly larger end surfaces in comparison with ferrite rods having beveled plane end section surfaces. The enlarged end surface of the spherical surface advantageously allows a more stable connection of individual magnetic core elements without adhesive bonding. This allows the construction of flexible, multiple-member and inexpensive rod core coils and antennae.