Abstract: A multiple chamber container forming and filling method includes (i) forming at least one strong seal around a periphery of first and second sheets so as to leave an opening between the first and second sheets; (ii) forming a temporary peel seal across the opening; (iii) forming a mixing peel seal between the first and second sheets so as to separate a diluent chamber from a powdered drug chamber; (iv) adding diluent to the diluent chamber; (v) sterilizing the multiple chamber container including the diluent; (vi) opening the temporary peel seal in an aseptic environment; (vii) adding powdered drug to the powdered drug chamber through the opening; and (viii) strong sealing the opening so as to be closed.

Abstract: A multiple chamber container includes a first sheet; a second sheet; a first peel seal between the first and second sheets, the first peel seal extending across the first and second sheets; wherein at a first time at least one strong seal is provided around a periphery of the first and second sheets so as to leave an opening between the first and second sheets, and wherein a second peel seal is provided between the first and second sheets, the second peel seal extending across the opening between the first and second sheets; and wherein at a second time the second peel seal is removed and the at least one strong seal is extended to seal the opening between the first and second sheets.

Abstract: A multiple chamber container forming and filling method includes (i) forming at least one strong seal around a periphery of first and second sheets so as to leave an opening between the first and second sheets; (ii) forming a temporary peel seal across the opening; (iii) forming a mixing peel seal between the first and second sheets so as to separate a diluent chamber from a powdered drug chamber; (iv) adding diluent to the diluent chamber; (v) sterilizing the multiple chamber container including the diluent; (vi) opening the temporary peel seal in an aseptic environment; (vii) adding powdered drug to the powdered drug chamber through the opening; and (viii) strong sealing the opening so as to be closed.

Abstract: A device for mixing at least two separate streams of components which, when mixed, form a combined fluid stream. The device comprises a conduit with at least two separate passageways leading to exit openings at an end face of the conduit. Each passageway communicates with a separate component stream and is arranged to direct the separate component stream in a downstream direction. The exit openings each have a predetermined cross-sectional flow area. A separate channel is located at a downstream end of each passageway exit opening. The channels are arranged to redirect the flow from each passageway to an axial direction. A single mixing chamber communicates with all of the separate channels, the mixing chamber being arranged to receive each of the component streams at an upstream end thereof and to permit a mixing of the component streams. An outlet is arranged downstream of the mixing chamber through which the combined fluid stream is dispensed.

Abstract: A device for mixing at least two separate streams of components which, when mixed, form a combined fluid stream. The device comprises a conduit with at least two separate passageways leading to exit openings at an end face of the conduit. Each passageway communicates with a separate component stream and is arranged to direct the separate component stream in a downstream direction. The exit openings each have a predetermined cross-sectional flow area. A separate channel is located at a downstream end of each passageway exit opening The channels are arranged to redirect the flow from each passageway to an axial direction. A single mixing chamber communicates with all of the separate channels, the mixing chamber being arranged to receive each of the component streams at an upstream end thereof and to permit a mixing of the component streams. An outlet is arranged downstream of the mixing chamber through which the combined fluid stream is dispensed.