Patents by Inventor John A.A. Ladias

John A.A. Ladias has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of screening for compounds with ability to alter apolipoprotein AI gene expression
    Patent number: 5721096
    Abstract: Activation of the apolipoprotein AI (apoAI) gene in mammalian liver cells has been studied, as described herein, and shown to depend on synergistic interactions between nuclear proteins which bind to three distinct sites within a hepatocyte-specific transcriptional enhancer located between nucleotides -222 to -110 5' of the human apoAI gene (relative to the transcription start site). Two proteins, the apoAI regulatory protein-1 and the retinoic acid receptor RXR.alpha., have been shown to regulate expression of the apoAI gene.
    Type: Grant
    Filed: June 8, 1994
    Date of Patent: February 24, 1998
    Assignee: Children's Medical Center Corporation
    Inventors: Sotirios K. Karathanasis, John A.A. Ladias, Jeffrey N. Rottman, Russell L. Widom