Abstract: Disclosed herein are compositions and methods for treating diseases characterized by expanded microsatellite repeats by impeding or inhibiting transcription of expanded microsatellite repeats.

Abstract: Apparatus and associated methods relate to forming an epitaxial layer of aluminum on an aluminum-nitride compound. The aluminum is epitaxially grown on the crystalline aluminum-nitride compound by maintaining temperature of a crystalline aluminum-nitride compound below a cluster-favoring temperature threshold within a vacuum chamber. Then, the crystalline aluminum-nitride compound is exposed to atoms of elemental aluminum for a predetermined time duration. The aluminum is epitaxially grown in this fashion for a predetermined time duration so as to produce a layer of epitaxial aluminum of a predetermined thickness. Such epitaxially-grown mono-crystalline aluminum has a lower resistivity than poly-crystalline aluminum.

Abstract: Systems, apparatuses, methods, and computer program products are disclosed for establishing shared trust between a client user and an agent user for a current communication. An example method includes providing a logon request for a client user account associated with a client user to a system device. The example method further includes determining an authentication sequence code using the mobile application in an instance in which the logon request was successfully authenticated and causing the authentication sequence code to be provided to the agent device associated with the agent user. The example method further includes receiving a shared trust decision message from the system device, wherein the shared trust decision message is indicative of a verification status for the current communication.

Abstract: Systems, apparatuses, methods, and computer program products are disclosed for establishing shared trust between a client user and an agent user for a current communication. An example method includes providing a logon request for a client user account associated with a client user to a system device. The example method further includes generating a candidate authentication sequence code message using the mobile application in an instance in which the logon request was successfully authenticated and providing the candidate authentication sequence code message to a system device. The example method further includes receiving a shared trust decision message from the system device, wherein the shared trust decision message is indicative of the current communication verification status.

Abstract: In an embodiment, a polyurethane comprises the residues of i. an aliphatic diisocyanate, ii. an aliphatic diol comprising a poly(ethylene oxide) moiety, iii. an aliphatic diol comprising a polycarbonate moiety, and iv. a chain extender, wherein the polyurethane has a melting temperature of 140° C. or less and has a weight average molecular weight of from 100,000 to 500,000 g/mol. In an embodiment, the polyurethane is substantially devoid of catalyst. In an embodiment, the polyurethane is formed by reactive extrusion. In an embodiment, a medical device comprises the polyurethane and a bioactive agent. The medical devices, methods, and polyurethanes may exhibit benefits in end-product biostability, drug release profile, health and safety, and processing speed or reproducibility.

Abstract: Systems, apparatuses, methods, and computer program products are disclosed for managing and securing sensitive electronic files. An example method includes obtaining, by interface circuitry, an electronic file associated with a third-party application. The method also includes determining, by a classification engine, a first classification of the electronic file. The method also includes, in an instance in which the first classification of the first electronic file corresponds to a first predefined classification, determining, by the classification engine, a second classification of the first electronic file, selecting, by an inbox allocation engine and based on the second classification of the electronic file, a first storage location associated with an electronic file inbox of a mobile banking application, and storing, by the inbox allocation engine, the electronic file in association with the first storage location.

Abstract: Devices and methods are provided that utilize two adjacent nanopore readers for sequencing of a polymer or a portion thereof.

Abstract: A baseball pitch selection communication system has a transmitter and a body-worn visual receiver. The transmitter includes a transmitter unit configured to transmit wireless signals, a first microcontroller and a plurality of user actuatable input elements. The first microcontroller is configured to provide the transmitter unit with a selection signal to wirelessly transmit in accordance with actuation of the user actuatable input elements, the selection signal corresponding to a pitch selection. The visual receiver includes a receiving unit configured to wirelessly receive the selection signal, a memory configured to contain a plurality of stored visual instructions, a display configured to display visual instructions, and a second microcontroller. The second microcontroller is configured to control the memory and the display to display a selected visual instruction in accordance with the received selection signal, where the selected visual instruction corresponds to the pitch selection.

Abstract: A system for communicating pitch selections wirelessly from a wireless transmitter has a coded signal generator that generates coded signals in accordance with selected pitch types. A receiver decodes the received coded signals, selects an audio file based on the received coded signal and generates an audio signal announcing the selected pitch type based on the transmitted selected pitch type in accordance with the received coded signal. The audio signal is transduced by a bone conductor transducer so that the player can hear the announced selected pitch type through bone conduction.

Abstract: The present disclosure relates to bonding a first substrate together a second substrate with adhesives that are substantially tackifier free. A layer of substantially tackifier free adhesive may be applied to a first surface of the second substrate to define an adherence zone, and the first substrate is positioned on the adherence zone of the second substrate to form a laminate. The first and second substrates are pressed against each other in the adherence zone to force the substantially tackifier free adhesive to penetrate into the first and second substrates. A first portion of the layer of the adhesive penetrates into the first substrate and a second portion of the layer of the adhesive penetrates into the second substrate. A central portion of the layer of the adhesive between the first and second portions separates the second surface of the first substrate from the first surface of the second substrate.

Abstract: A sensor assembly for a prosthetic or orthotic device (POD) may include a housing and a support. The housing may be attached with the POD. The support may be moveably connected with the housing such that the support may move relative to the housing. The support may form an enclosure with the housing. Within the enclosure, the sensor assembly may include one or more sensors and a circuit board. The one or more sensors may include one or more of an inertial measurement unit, an electromyography sensor, or a distance sensor such as a magnetic sensor and a magnet. The circuit board may be attached with the support and in electrical communication with the plurality of sensors. Movement of the support may cause the sensors to move which may be detected for control of the POD. The sensor assembly may be attached to an arm or other prosthetic socket for detection of natural limb movements.

Abstract: Methods, systems, and computer storage media for providing a set of common flat files in a composite image that can be mounted as a container (i.e. composite container) to support isolation and interoperation of computing resources. Container management is provided for a container management system based on a composite image file system engine that executes composite operations to support resource isolation and operating system (OS) virtualization functionality. In particular, a layout manager operates with a composite engine interface to support generating composite images with optimized configurations (i.e., pre-alignment and pre-computed hashes of for executable files). In operation, a plurality of files for generating a composite image are accessed.

Abstract: Systems, apparatuses, methods, and computer program products are disclosed for distributing digital rewards between third parties. An example method includes receiving rewards data representative of at least a digital rewards profile comprising a digital rewards amount for a digital rewards program of a user and receiving a rewards mapping request comprising instructions to identify one or more available digital rewards sources compatible with the digital rewards amount. The example method further includes identifying one or more digital rewards sources comprising one or more of a second digital rewards profile comprising a second digital rewards amount, a promotion of the digital rewards program, or an incentive multiplier and causing transmission of at least one of a predefined digital rewards amount or the promotion of the digital rewards program. The example method further includes executing a purchase transaction for a product associated with a product cost of the digital rewards program.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: A covert sports communication system has a transmitter configured to wirelessly transmit both coded audio track selection signals and vocalization signals encoding vocalizations. The system includes a receiver that sized and shaped to be worn within headgear. The receiver includes stored audio tracks and is configured to receive coded audio track selection signals from the transmitter, decode the audio track selection signals, and play at least one stored audio track in accordance with the decoded audio track selection signals. The audio tracks may include audio instructions to a participant of a sporting event. The receiver is also configured to audible reproduce the vocalization.

Abstract: A system, including: a plurality of load commutated inverters (LCIs) connected in parallel, wherein each LCI includes: a source bridge for converting an alternating current (AC) voltage to a direct current (DC) voltage, wherein the source bridge includes at least one current switching device; a load bridge for converting the DC voltage from the source bridge to a variable frequency AC voltage; and a DC link coupling the source bridge to the load bridge; wherein each LCI includes a respective current regulator for controlling the at least one current switching device in the source bridge of the LCI to generate a current in the DC link.

Abstract: Apparatuses, systems, and methods for brewing a desired portion of a beverage, such as a single-cup portion of coffee, are provided. The system can include one or more hopper assemblies configured to provide a controlled dose of beverage material to a brew chamber. The system can also include a water input system configured to wet the ground beverage material as the grinds enter the brew chamber and substantially prevent steam from reaching grinder components of the system. Further, the system can include an automatic cleaning mechanism such that a user does not need to manually clean components of a brewing machine between brew cycles.

Abstract: One embodiment where a support holds the book, and an arm is pivotally attached to near the center of the support. It rotates the same way with a book. The arm can be releasably locked to the support. The arm is placed adjacent to the support so it can be pried open. One end of the line is attached to the distal end of the arm. The other is anchored to the opposite end of the support. The length of the line across the support can be changed. The arm can be in the open position or the closed position. An open book is sandwiched between the support and the line in the closed position.