Patents by Inventor John A. Beisler

John A. Beisler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis, structure, and antitumor activity of 5,6-dihydro-5-azacytidine
    Patent number: 4058602
    Abstract: The compound 5,6-dihydro-5-azacytidine, 5AC[H], and non-toxic acid addition salts such as the hydrochloride, together with its preparation from 5-azacytidine (5-AC) by reduction of the 5,6-double bond of 5-AC with an alkali metal borohydride such as sodium borohydride. Additionally, 5,6-dihydro-5-azacytidine, 5AC[H], has antitumor activity for murine leukemia systems L1210 and P388 as an injectable. In comparison with the parent compound, 5-AC, the antitumor activity is comparable and 5AC[H] exhibits a more favorable therapeutic index. It also has better solution stability over a broad pH range. A structure for the HCl salt is given below.
    Type: Grant
    Filed: August 9, 1976
    Date of Patent: November 15, 1977
    Assignee: The United States of America as represented by the Department of Health, Education and Welfare
    Inventors: John A. Beisler, Mohamed M. Abbasi, John S. Driscoll