Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: Described herein are compounds of Formula (I) and pharmaceutically acceptable salts thereof, as well as pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, such as cancer, metabolic and blood disorders. Compounds of Formula (I) have the following structure of Formula (I).

Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: A processor assembly including: an exposure station operable to expose a sample on a slide; a print station operable to apply a reagent to the exposed sample through a thermal inkjet process; and a robotic transfer mechanism to transfer the slide from the exposure station to the print station. Also, a reagent cartridge including: a body defining a container having a volume therein; a nonmetallic bag in the container operable to contain a reagent; and a printhead at a base of the body, the printhead coupled to an outlet of the bag. Further, a method including exposing a sample on a slide in a processor assembly; robotically transferring the slide to a printing station of the processor assembly; and applying a reagent to the exposed sample at the printing station by a thermal inkjet printing process.

Abstract: A processor assembly including a core module operable to expose a sample on a slide; a staining module operable to apply a stain to the exposed sample; and a robotic transfer mechanism to transfer the slide from the core module to the staining module. Also, an apparatus including a rectangular body having an open rear end and an opposite front end; a flange having a first side and a second side, wherein the first side of the flange is coupled to the front end of the body; and a pair of legs extending from second side of the flange, wherein the pair of legs are operable to engage opposite side edges of a slide.

Abstract: A remotely deployed untethered device for actuation of a downhole application. The device may be equipped with inductive measurement capacity for interaction with a downhole well architecture. Such capacity affords the ability to trigger an actuation remotely at a site specific location in the well without further intervention relative surface equipment.

Abstract: A technique includes deploying an untethered object though a passageway of a string in a well; and sensing a property of an environment of the string, an electromagnetic coupling or a pressure as the object is being communicated through the passageway. The technique includes selectively autonomously operating the untethered object in response to the sensing.

Abstract: An electric submersible pump device has a pump and a motor. The motor can be adjacent to the pump. A support member supports the sensor and has a length so that the sensor is located a first distance downhole from a downhole distal end of the motor.

Abstract: A system can include a transformer and a rectifier to derive DC power from AC power at a wye point of an electric motor; a sensor that includes a sensor signal output to output a sensor signal; a telemetry driver that includes a DC power input to receive the derived DC power and that includes an input to receive the sensor signal and an output to output a data signal representing the sensor signal; and circuitry to deliver the data signal representing the sensor signal to the wye point of the electric motor. Various other apparatuses, systems, methods, etc., are also disclosed.

Abstract: A remotely deployed untethered device for actuation of a downhole application. The device may be equipped with inductive measurement capacity for interaction with a downhole well architecture. Such capacity affords the ability to trigger an actuation remotely at a site specific location in the well without further intervention relative surface equipment.

Abstract: Exemplary embodiments provide computer-implemented methods, computer-readable media, and systems for changing the identifier associated with an entity, such as a variable or function, in a portion of code. During editing, a reference may be maintained that identifies the location of each instance of the entity in the code. When the identifier associated with one instance of the entity is changed, the change in the identifier may be propagated throughout the code to change each instance of the identifier in the code. The identifier may be changed without interrupting the workflow of the user and without the need to change to a separate refactoring mode. In some embodiments, a syntactical analysis may be performed and some or all instances of the identifier may be changed based on one or more rules.

Abstract: A system can include a transformer and a rectifier to derive DC power from AC power at a wye point of an electric motor; a sensor that includes a sensor signal output to output a sensor signal; a telemetry driver that includes a DC power input to receive the derived DC power and that includes an input to receive the sensor signal and an output to output a data signal representing the sensor signal; and circuitry to deliver the data signal representing the sensor signal to the wye point of the electric motor. Various other apparatuses, systems, methods, etc., are also disclosed.

Abstract: A technique includes deploying an untethered object though a passageway of a string in a well; and sensing a property of an environment of the string, an electromagnetic coupling or a pressure as the object is being communicated through the passageway. The technique includes selectively autonomously operating the untethered object in response to the sensing.

Abstract: A data communication system for use in downhole applications wherein electrical energy is supplied over a multiple-conductor power cable to an ESP motor assembly. A downhole unit is AC-coupled to the conductors of the power cable through the wye point of the ESP motor assembly. A surface unit is AC-coupled to the conductors of the power cable. Uplink communication of telemetry data occurs over an AC communication scheme supported by the downhole unit and the surface unit. Downlink communication of remote control command data occurs over a different AC communication scheme supported by the surface unit and the downhole unit. These AC communication schemes provide an independent supply of power to the downhole environment. All communication between the surface and downhole environment is accomplished through the power cable without the use of additional communication lines. Data communication is maintained in the event of a ground fault on the power cable.

Abstract: A wireline telemetry system and method of transmitting data on multiple carrier frequencies. The system and method adjust power level and number of bits-per-carrier to optimally or near-optimally utilize the capacity of the wireline cable. Due to the nature of wireline telemetry the overall power level is restricted only by the output capability of the downhole telemetry cartridge and the input power restrictions of the uphole telemetry unit receiver. The optimal power level is determined during a training sequence and is a function of such factors as cable length, cable material, cable temperature and cable geometry. The uplink and downlink transmission are executed using different modulation techniques.

Abstract: An electric submersible pump device, comprising an electric motor having stators and coils; a pump coupled with the electric motor; a thermocouple or RTD for measuring temperature of the motor windings.

Abstract: A system and method is provided for sensing parameters within a wellbore. At least one sensor sub is coupled between stage components of an electric submersible pumping system. A plurality of sensor subs can be disposed between adjacent pairs of stage components to obtain sensor data along the electric submersible pump string. Each sensor sub contains a sensor element or elements designed to sense parameters internal and/or external to the electric submersible pumping system.

Abstract: An electric submersible pump device having a pump; a motor, the motor being adjacent to the pump and having motor windings extending a first distance along the motor; a support member, the support member supporting the sensor and having a length so that the sensor is located the first distance downhole from a downhole distal end of the motor windings; the sensor device comprising at least one selected from the following: a temperature sensor, a flow-meter, a vibration sensor or a pressure sensor.

Abstract: A data communication system for use in downhole applications wherein electrical energy is supplied over a multiple-conductor power cable to an ESP motor assembly. A downhole unit is AC-coupled to the conductors of the power cable through the wye point of the ESP motor assembly. A surface unit is AC-coupled to the conductors of the power cable. Uplink communication of telemetry data occurs over an AC communication scheme supported by the downhole unit and the surface unit. Downlink communication of remote control command data occurs over a different AC communication scheme supported by the surface unit and the downhole unit. These AC communication schemes provide an independent supply of power to the downhole environment. All communication between the surface and downhole environment is accomplished through the power cable without the use of additional communication lines. Data communication is maintained in the event of a ground fault on the power cable.

Abstract: A system and method is provided for sensing parameters within a wellbore. At least one sensor sub is coupled between stage components of an electric submersible pumping system. A plurality of sensor subs can be disposed between adjacent pairs of stage components to obtain sensor data along the electric submersible pump string. Each sensor sub contains a sensor element or elements designed to sense parameters internal and/or external to the electric submersible pumping system.