Abstract: Timing-based methods, systems, and computer readable mediums for a gated linear accelerator include synchronising a local clock of the linear accelerator with a clock of a patient monitoring system, determining latencies within one or more MR-gated radiotherapy processes and implementing latency based interlocks.

Abstract: Systems and methods for controlling operation of a vehicle system are provided. This vehicle system can be at least partially powered by electric current conducted to a collector device of the vehicle system from a conductive pathway extending along a route traveled by the vehicle system. A voltage level of the conductive pathway may be monitored, and a conduction impaired location of the conductive pathway may be identified based at least in part on the voltage level of the conductive pathway that is monitored. The collector device or a removal device may be controlled to remove a contaminant from the conductive pathway at the conduction impaired location, the vehicle system may be controlled to compensate for the conduction impaired location, and/or an off-board facility and/or another vehicle system may be notified of the conduction impaired location responsive to identifying the conduction impaired location.

Abstract: A method including detecting that a vehicle that may be propelled by an electric drive system having one or more motors disconnects or begins disconnecting from an off-board source of power while the one or more motors are being powered by the off-board source of power. The method may include supplanting a decreasing amount of a first electric energy supplied by the off-board source of power to the electric drive system with an amount of a second electric energy supplied by an onboard source of power to the electric drive system responsive to the detection of the disconnect from the off-board source of power.

Abstract: A device and method are presented. Largest and smallest successful values of a receive clock delay and a transmit clock delay are determined. A first set of parameters for an SPI coupled to a DDR flash memory are set, including the largest successful values of the transmit clock delay and the receive clock delay, and a first value of a RD cycle. A second set of parameters for the SPI are set, including the smallest successful value of the transmit clock delay and receive clock delay, and a second value of the RD cycle. One of the first and second sets of parameters is selected based on whether the first or second set of parameters results in successfully reading from the DDR flash memory over a larger range of operating temperatures. The SPI is programmed using the selected one of the first and second sets of parameters.

Abstract: A bone cleaning assembly with cleaning elements that remove soft tissue from bone stock. The module also includes a clearing element that is periodically urged against the cleaning elements to remove bone stock trapped by the cleaning elements from the cleaning elements.

Abstract: Provided herein is a method of characterising a target polynucleotide as it moves with respect to a nanopore using a motor protein. Also provided are polynucleotide adapters and kits comprising such adapters. The methods, kits and adapters find use in characterising polynucleotides, for example in sequencing.

Abstract: A method of operating a device, which includes providing a user interface with a display artifact; in response to an indication a user selected to copy the display artifact, storing multiple levels of detail of the display artifact; allowing the user to paste a selected level of detail by steps of: in response to an indication a user selected an input field and a paste command, displaying a plurality of paste options for pasting the display artifact into the input field, wherein the plurality of paste options each have a unique level of detail for representing the display artifact; allowing the user to select from the plurality of paste options; and in response to an indication a user selected a paste option from the plurality of paste options, pasting the display artifact with a level of detail associated with the selected paste option into the input filed.

Abstract: The method of manufacturing a magnetic rotor unit comprises providing a composite magnetic rotor body. The composite magnetic rotor body comprises magnetic particles dispersed in a polymer resin. The composite magnetic rotor body has a hole. The method further comprises inserting a shaft into the hole. The outer diameter of the shaft corresponds to the inner diameter of the hole. The method further comprises heating of the shaft. By heating the shaft, the elevated temperature of the shaft surface preferentially induces the polymer resin from an inner surface of the hole to exude or sweat on to the shaft surface, so as to provide a bonding layer between the magnetic rotor body and the shaft. An apparatus for such manufacture, and a magnetic rotor unit manufactured by such method, are also provided. Such rotor units have wide application, and may for example be used in sensors, electromagnetic generators, pulse generators, motors, magnetic brakes and magnetic couplings.

Abstract: A sequence of polymer units in a polymer (3), eg. DNA, is estimated from at least one series of measurements related to the polymer, eg. ion current as a function of translocation through a nanopore (1), wherein the value of each measurement is dependent on a k-mer being a group of k polymer units (4). A probabilistic model, especially a hidden Markov model (HMM), is provided, comprising, for a set of possible k-mers: transition weightings representing the chances of transitions from origin k-mers to destination k-mers; and emission weightings in respect of each k-mer that represent the chances of observing given values of measurements for that k-mer. The series of measurements is analysed using an analytical technique, eg. Viterbi decoding, that refers to the model and estimates at least one estimated sequence of polymer units in the polymer based on the likelihood predicted by the model of the series of measurements being produced by sequences of polymer units.

Abstract: An apparatus is described. The apparatus includes a balloon venting system. The balloon venting system includes a clamp. The clamp is to clamp to the balloon so as to bear a mechanical load away from an opening in the balloon. The balloon venting system includes a fluidic channel that is coupled to the opening in the balloon. The opening in the balloon is not located at the bottom of the balloon. The balloon venting system includes an electro-mechanical device that is mechanically coupled to a valve. The electro-mechanical device is to drive the valve to open the channel so that gas within the balloon escapes the balloon when the valve is open and to close the channel so that gas remains within the balloon when the valve is closed.

Abstract: An equipment mounting system for mounting equipment to a support structure is described. An equipment mounting system including: (i) a mounting plate having defined therein a plate aperture of a particular shape; (ii) a bolt having a shaft portion including a threaded portion and a non-threaded portion that is of a complementary shape that complements the particular shape of the plate aperture; and (iii) a washer having defined therein a scored aperture that includes multiple radially extending scorings. In an assembled configuration of the mounting plate, the bolt and the washer, the plate aperture of the particular shape aligns with the scoring aperture such that both of the plate aperture and the scoring aperture receive the non-threaded portion of the complementary shape, and the particular shape of the mounting plate engages with the complementary shape of the bolt to prevent rotational displacement of the bolt around the mounting plate.

Abstract: An insulated wire or cable is made by a process comprising the steps of: (A) extruding onto a covered or uncovered metal conductor or optical fiber a composition having a DF measured at 130° C. (60 Hz, 2 kV) or 120° C. (60 Hz, 8 kV) or 100° C. (60 Hz, 8 kV) of ?0.5% and comprising: (1) a high melt strength ethylene-based polymer made in a tubular reactor, and (2) a peroxide, and (B) crosslinking the high melt strength ethylene-based polymer.

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R3, R4a, R4b, R4c, R4d, R4f, X1, X2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, R4, R4a, R4b, R4c, R4d, R4e, R4f, R5, R6 have the meaning as indicated in the description and claims The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating or preventing of one or more diseases or disorders associated with integrated stress response.

Abstract: Systems and methods for generating three-dimensional models with correlated three-dimensional and two dimensional imagery data are provided. In particular, imagery data can be captured in two dimensions and three dimensions. Imagery data can be transformed into models. Two-dimensional data and three-dimensional data can be correlated within models. Two-dimensional data can be selected for display within a three-dimensional model. Modifications can be made to the three-dimensional model and can be displayed within a three-dimensional model or within two-dimensional data. Models can transition between two dimensional imagery data and three dimensional imagery data.

Abstract: A network element includes at least two Time Division Multiplexing (TDM) modules each including a TDM client interface, TDM processing circuitry, and circuit emulation circuitry; and a packet switch fabric connected to the at least two TDM modules in a Link Aggregation Group (LAG) for a protected TDM service, and configured to output a packet interface, wherein the protected TDM service is provided as a single packetized TDM stream via the packet interface from the packet switch fabric.

Abstract: Provided are imaging agents comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, and methods of their use.

Abstract: The present invention relates to a support structure for supporting a top structure, in particular a wind turbine, above the ground or a seabed, the support structure comprising: one single support pile having a length and a first outer diameter, the one single support pile comprising an upper part configured and intended to extend above the ground or the seabed, wherein the upper part of the support pile is configured to be connected to the top structure; a lower part configured to be in contact with the ground or seabed, wherein the support pile is configured to exert an upward vertical force on the top structure in order to carry the top structure; a plurality of foundation guides connected to the lower part of the single support pile, each foundation guide having an opening extending in a direction of the support pile.

Abstract: The present invention relates to compounds of formula (I) or pharmaceutically acceptable salts, solvates, hydrates, tautomers or stereoisomers thereof, wherein R1, R2, R2a, R3, Ra1, Ra2, Ra4, Ra5, X1, X1a, A1 and A2 have the meaning as indicated in the description and claims. The invention further relates to pharmaceutical compositions comprising said compounds, their use as medicament and in a method for treating and preventing of one or more diseases or disorders associated with integrated stress response.