Patents by Inventor John A. Chiorini

John A. Chiorini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bovine adeno-associated viral (BAAV) vector and uses thereof
    Patent number: 9193769
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Grant
    Filed: February 13, 2014
    Date of Patent: November 24, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • METHODS FOR THE DIAGNOSIS AND TREATMENT OF SJÖGREN'S SYNDROME
    Publication number: 20150273083
    Abstract: Described herein is the finding that patients with Sjögren's syndrome exhibit a statistically significant increase in expression of BMP6 in the salivary gland, relative to healthy control subjects. Also described herein is the finding that overexpression of BMP6 in the salivary glands of mice results in an increase in electrical potential across the salivary gland. Thus, provided herein are methods of diagnosing a subject as having Sjögren's syndrome, or at risk for developing Sjögren's syndrome, by measuring the level of BMP6 expression in a salivary gland of a subject, measuring electrical potential in a salivary gland of a subject, or both. Also provided herein are methods of treating a subject with Sjögren's syndrome by administering an agent that inhibits expression of BMP6 expression or activity. Also described herein is the use of XIST and MECP2 as diagnostic and therapeutic targets for male Sjögren's syndrome patients.
    Type: Application
    Filed: September 25, 2013
    Publication date: October 1, 2015
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: John A. Chiorini, Melodie Weller, Hongen Yin
  • AAV MEDIATED AQUAPORIN GENE TRANSFER TO TREAT SJOGREN'S SYNDROME
    Publication number: 20150203553
    Abstract: The invention relates to a gene transfer-based method to protect a subject from Sjogren's syndrome. The method comprises administering to the subject an AAV virion comprising an AAV vector that encodes aquaporin-1 (AQP-1) protein. Also provided are AQP-1 proteins and nucleic acid molecules that encode such proteins. Also dr GFP provided are AAV vectors and AAV virions that encode an AQP-1 protein.
    Type: Application
    Filed: August 30, 2013
    Publication date: July 23, 2015
    Inventor: John Chiorini
  • Avian Adenoassociated Virus and Uses Thereof
    Publication number: 20150152393
    Abstract: The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles.
    Type: Application
    Filed: November 26, 2014
    Publication date: June 4, 2015
    Inventors: Ioannis Bossis, John A. Chiorini
  • Avian adenoassociated virus and uses thereof
    Patent number: 8927269
    Abstract: The present invention provides an Avian adeno-associated virus (AAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAAV vectors and particles. Methods of isolating the AAAV are provided.
    Type: Grant
    Filed: May 18, 2004
    Date of Patent: January 6, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Ioannis Bossis, John A. Chiorini
  • AAV4 VECTOR AND USES THEREOF
    Publication number: 20140348794
    Abstract: The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.
    Type: Application
    Filed: August 14, 2014
    Publication date: November 27, 2014
    Inventors: John A. Chiorini, Robert M. Kotin, Brian Safer
  • EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) AND METHODS OF USE IN ADENOVIRAL-ASSOCIATED VIRUS TYPE 6 (AAV6) TRANSDUCTION
    Publication number: 20140296326
    Abstract: Comparative gene analysis (CGA) was combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. It was found that EGFR is necessary for vector internalization and functions as a co-receptor for AAV6. The identification and characterization of AAV6's requirement of EGFR expression for high transduction activity has allowed construction of recombinant AAV6 vectors which are capable of targeting and killing specific types of head and neck tumors that because of this high EGFR activity, were until now, refractory to current therapies.
    Type: Application
    Filed: June 11, 2014
    Publication date: October 2, 2014
    Inventors: John Chiorini, Melodie L. Weller, Michael Schmidt
  • AAV4 vector and uses thereof
    Patent number: 8846389
    Abstract: The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.
    Type: Grant
    Filed: July 2, 2013
    Date of Patent: September 30, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Robert M. Kotin, Brian Safer
  • Epidermal growth factor receptor (EGFR) and methods of use in adenoviral-associated virus type 6 (AAV6) transduction
    Patent number: 8808684
    Abstract: Comparative gene analysis (CGA) was combined with pathway visualization software to identify a positive correlation between AAV6 transduction and epidermal growth factor receptor (EGFR) expression. It was found that EGFR is necessary for vector internalization and functions as a co-receptor for AAV6. The identification and characterization of AAV6's requirement of EGFR expression for high transduction activity has allowed construction of recombinant AAV6 vectors which are capable of targeting and killing specific types of head and neck tumors that because of this high EGFR activity, were until now, refractory to current therapies.
    Type: Grant
    Filed: September 10, 2010
    Date of Patent: August 19, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John Chiorini, Michael Schmidt, Melodie L. Weller
  • Bovine Adeno-Associated Viral (BAAV) Vector and Uses Thereof
    Publication number: 20140221636
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Application
    Filed: February 13, 2014
    Publication date: August 7, 2014
    Applicant: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • AAV MEDIATED EXENDIN-4 GENE TRANSFER TO SALIVARY GLANDS TO PROTECT SUBJECTS FROM DIABETES OR OBESITY
    Publication number: 20140199272
    Abstract: The invention relates to a gene transfer-based method to protect a subject from diabetes or obesity. The method comprises administering to a salivary gland of the subject an AAV virion comprising an AAV vector that encodes an exendin-4 protein. Also provided are exendin-4 proteins and nucleic acid molecules that encode such exendin-4 proteins. Also provided are AAV vectors and AAV virions that encode an exendin-4 protein. One embodiment is an exendin-4 protein that is a fusion protein comprising an NGF secretory segment joined to the amino terminus of an exendin-4 protein domain.
    Type: Application
    Filed: April 19, 2012
    Publication date: July 17, 2014
    Applicants: Health and Human Services
    Inventors: John A. Chiorini, Giovanni Di Pasquale, Edoardo Mannucci
  • AAV MEDIATED CTLA-4 GENE TRANSFER TO TREAT SJOGREN'S SYNDROME
    Publication number: 20140147418
    Abstract: The invention relates to a gene transfer-based method to protect a subject from Sjogren's syndrome. The method comprises administering to the subject an AAV virion comprising an AAV vector that encodes a soluble CTLA-4 (sCTLA-4) protein. Also provided are sCTLA-4 proteins and nucleic acid molecules that encode such sCTLA-4 proteins. Also provided are AAV vectors and AAV virions that encode a sCTLA-4 protein.
    Type: Application
    Filed: April 13, 2012
    Publication date: May 29, 2014
    Applicant: THE US OF AMERICA, AS REPRESENTED BY THE SECRETARY DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: John A. Chiorini, Hongen Yin
  • Bovine adeno-associated viral (BAAV) vector and uses thereof
    Patent number: 8685722
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Grant
    Filed: March 6, 2012
    Date of Patent: April 1, 2014
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • TRANSDUCTION OF CELLS BY ADENO-ASSOCIATED VIRUS VECTORS
    Publication number: 20140088175
    Abstract: The present invention provides methods of transcytosing barrier epithelial cells using adeno-associated virus-4 (AAV4), adeno-associated virus-5 (AAV5), adeno-associated virus-7 (AAV7), bovine adeno-associated virus (BAAV), and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid across the barrier epithelia using the AAV4, AAV5, AAV7, and BAAV vectors and particles.
    Type: Application
    Filed: March 9, 2012
    Publication date: March 27, 2014
    Applicant: The USA, as represented by the Secretary, Dept. of Health and Human Services
    Inventors: John A. Chiorini, Giovanni Di Pasquale
  • Isolation, Cloning and Characterization of New Adeno-Associated Virus (AAV) Serotypes
    Publication number: 20140024013
    Abstract: The present invention provides new adeno-associated virus (AAV) viruses and vectors, and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV vectors and particles.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 23, 2014
    Applicants: Human Services
    Inventors: Michael SCHMIDT, John A. CHIORINI
  • AAV4 VECTOR AND USES THEREOF
    Publication number: 20130337543
    Abstract: The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.
    Type: Application
    Filed: July 2, 2013
    Publication date: December 19, 2013
    Applicant: The USA, as represented by the Secretary, Department of Health and Human Services
    Inventors: John A. Chiorini, Robert M. Kotin, Brian Safer, Nancy Safer
  • AAV4 vector and uses thereof
    Patent number: 8507267
    Abstract: The present invention provides an adeno-associated virus 4 (AAV4) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV4 vectors and particles.
    Type: Grant
    Filed: March 8, 2010
    Date of Patent: August 13, 2013
    Assignee: U.S. Dept. of Health and Human Services, National Institutes of Health
    Inventors: John A. Chiorini, Robert M. Kotin, Nancy Safer
  • Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes
    Patent number: 8283151
    Abstract: The present invention provides new adeno-associated virus (AAV) viruses and vectors, and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the AAV vectors and particles.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: October 9, 2012
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Michael Schmidt, John A. Chiorini
  • Bovine Adeno-Associated Viral (BAAV) Vector and Uses Thereof
    Publication number: 20120253018
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Application
    Filed: March 6, 2012
    Publication date: October 4, 2012
    Applicants: Human Services
    Inventors: John A. Chiorini, Michael Schmidt, Ioannis Bossis, Giovanni Di Pasquale
  • Bovine adeno-associated viral (BAAV) vector and uses thereof
    Patent number: 8137960
    Abstract: The present invention provides a bovine adeno-associated virus (BAAV) virus and vectors and particles derived therefrom. In addition, the present invention provides methods of delivering a nucleic acid to a cell using the BAAV vectors and particles.
    Type: Grant
    Filed: December 6, 2004
    Date of Patent: March 20, 2012
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Michael Schmidt, Ioannis Bossis, John A. Chiorini