Abstract: The present invention relates to analgesic treatments to reduce pain through use of an inhibitor of fatty-acid amide hydrolase pseudogene (FAAH-OUT).

Abstract: According to the present disclosure there is provided a wiper assembly for removing contaminants from a surface of a housing provided around a sensor, comprising: a drive system; a moveable part connected to the drive system to be driven by the drive system; and at least one wiper connected to the moveable part, wherein the drive system is configured to drive the moveable part, thereby to cause movement of the at least one wiper at least partially around the housing thereby to wipe the surface of the housing to remove contaminants therefrom. Further, according to the present disclosure there is provided: a sensor assembly comprising a sensor and a wiper assembly; a vehicle; and a method of operating a wiper assembly.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: Provided herein are absorbent materials for wound dressings, a bandage comprising an absorbent pad and methods for making the absorbent pad. The absorbent pad comprises a first layer comprising a polymer, such as an extruded apertured polymeric film, and a second layer thermally bonded to the first layer. The second layer comprises at least one thermally bondable fiber, such as a bicomponent fiber having at least a first material with a higher melting point than a second material. The first and second layers are bonded to each other such that the three-dimensional structure and the inherent porosity of the polymeric mesh is substantially maintained, resulting in a bilayer absorbent pad with increased absorbency and enhanced wicking capabilities.

Abstract: The present invention provides liquid repellent slippery surfaces and methods or preparing the same. The surface comprises a substrate, the substrate surface being functionalised via the deposition of a polymer layer thereon, and a lubricant impregnated into the polymer layer, thereby forming said liquid repellent slippery surface. The polymer layer comprises an aromatic ring-containing polymer layer; and the lubricant is an aliphatic compound, rapeseed oil, olive oil, vacuum pump oil, cinnamaldehyde a cinnamaldehyde derivative, essential oil or an essential oil-derived compound. The present invention also provides a liquid repellent slippery surface, wherein the surface comprises a substrate and associated substrate surface, the substrate surface functionalised via the deposition of a polymer layer thereon. The polymer layer is formed from a functional monomer precursor comprising a siloxane-group containing monomer or an alkyl-group containing monomer.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: Described herein are, among other things, techniques, devices, and systems for generating one or more trained machine-learning models used for generating content-item recommendations. Also described herein are techniques, devices, and systems for applying a consumption history of a particular user to the trained model(s) to generate score data indicating a correlation between each content-item title and the consumption history, as well as modifying this score data using one or more biasing factors for generating result data. In addition, the techniques, devices, and systems may use this result data, along with received user input, for determining an order in which to present one or more content items to the user. For example, this may include determining which content items to recommend to a user and in which order to do so.

Abstract: Described herein are, among other things, techniques, devices, and systems for generating one or more trained machine-learning models. Also described herein are techniques, devices, and systems for applying a consumption history of a particular user to the trained model(s) to generate score data indicating a correlation between each content-item title and the consumption history. The techniques then determine a ranked list of content items having a highest correlation to the consumption history, which may be used to retrieve videos associated with the most-correlated content items for generating a compilation video composed of these retrieved videos.

Abstract: One embodiment is an apparatus for inhibiting accidental contact by a human with a tail rotor connected to an empennage of an aircraft. The apparatus includes an inverted V-tail connected to an empennage of the aircraft forward of the tail rotor, the inverted V-tail stabilizer comprising a first V-tail stabilizer on a side of the empennage to which the tail rotor is connected and a second V-tail stabilizer on a side of the empennage opposite the side of the empennage to which the tail rotor is connected; and a shroud bar having a first end connected to an outboard end of the first V-tail stabilizer and a second end opposite the first end connected to the empennage aft of the tail rotor, wherein a horizontal distance from the shroud bar to the tail rotor is greater than a length of an arm of the human.

Abstract: An anchoring device for use in retaining a railway rail fastening clip having first and second leg portions and a rail-bearing portion therebetween. The anchoring device includes a base member, an opening in the base member configured to receive a fastening component for fastening the anchoring device to an underlying foundation, and first and second clip-retaining sides extending from said base member with the first clip-retaining side being spaced apart from the second clip-retaining side so as to define a space therebetween for receiving the rail-bearing portion of the clip. Each clip-retaining side comprising upper and lower clip contact walls defining a passageway for receiving one of the leg portions, wherein the leg portions contact the clip contact walls of the respective clip-retaining sides as the clip moves from a wedged position towards an engaged position where the rail-bearing portion of the clip bears on the rail.

Abstract: The present invention provides a coating comprising cinnamaldehyde, a cinnamaldehyde derivative, an essential oil, or an essential oil-derived compound; and a polyphenol, polyethyleneimine or poly(4-vinylaniline). The invention also provides a coating comprising cinnamaldehyde, a cinnamaldehyde derivative, an essential oil, or an essential oil-derived compound; a metal, metal-salt or metal-compound; and a polyphenol or a polyphenol-containing substance or solution. Substrates including the coatings applied thereto, and methods of preparing the coatings are also provided.

Abstract: Described herein are, among other things, techniques, devices, and systems for generating one or more trained machine-learning models used for generating content-item recommendations. Also described herein are techniques, devices, and systems for applying a consumption history of a particular user to the trained model(s) to generate score data indicating a correlation between each content-item title and the consumption history, as well as modifying this score data using one or more biasing factors for generating result data. In addition, the techniques, devices, and systems may use this result data, along with received user input, for determining an order in which to present one or more content items to the user. For example, this may include determining which content items to recommend to a user and in which order to do so.

Abstract: Methods of assessing wear of an electrical insulator and rail pad of an assembled rail fastening system utilize data from a 3D scan of the system to derive measurements of the system from which wear of the side post of the electrical insulator, or wear of the rail pad beneath the rail, may be assessed.

Abstract: A trained machine learning model(s) is used to determine scores (e.g., trust scores) for user accounts registered with a video game service, and the scores are used to match players together in multiplayer video game settings. In an example process, a computing system may access data associated with registered user accounts, provide the data as input to the trained machine learning model(s), and the trained machine learning model(s) generates the scores as output, which relate to probabilities of players behaving, or not behaving, in accordance with a particular behavior while playing a video game in multiplayer mode. Thereafter, subsets of logged-in user accounts executing a video game can be assigned to different matches based at least in part on the scores determined for those logged-in user accounts, and the video game is executed in the assigned match for each logged-in user account.

Abstract: Described herein are, among other things, techniques, devices, and systems for generating one or more trained machine-learning models used for generating content-item recommendations. Also described herein are techniques, devices, and systems for applying a consumption history of a particular user to the trained model(s) to generate score data indicating a correlation between each content-item title and the consumption history, as well as modifying this score data using one or more biasing factors for generating result data. In addition, the techniques, devices, and systems may use this result data, along with received user input, for determining an order in which to present one or more content items to the user. For example, this may include determining which content items to recommend to a user and in which order to do so.

Abstract: Described herein are, among other things, techniques, devices, and systems for generating one or more trained machine-learning models. Also described herein are techniques, devices, and systems for applying a consumption history of a particular user to the trained model(s) to generate score data indicating a correlation between each content-item title and the consumption history. The techniques then determine a ranked list of content items having a highest correlation to the consumption history, which may be used to retrieve videos associated with the most-correlated content items for generating a compilation video composed of these retrieved videos.

Abstract: The present disclosure relates, in general, to improved processes for the preparation of 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)-benzamide, particularly large-scale processes for manufacturing 4-{8-amino-3-[(2S)-1-(but-2-ynoyl)pyrrolidin-2-yl]imidazo[1,5-a]pyrazin-1-yl}-N-(pyridin-2-yl)benzamide and intermediates used in such processes.

Abstract: A system for tissue dissection and retraction is disclosed herein. A tissue dissection assembly generally comprises an elongate body shaft, an actuation member movable relative to the elongate body shaft, and at least one dissector arm member having at least a first end attached to the elongate body shaft, wherein the at least one dissector arm member is adapted to reconfigure within a plane from a low profile to an expanded profile when urged via the actuation member, and wherein the at least one dissector arm is further adapted to dissect tissue within the plane. In use, the assembly dissects tissue within the plane typically by advancing the elongate body shaft into the tissue region where the dissector arm member or members are then reconfigured within the plane from its low profile to its expanded profile to thereby dissect the tissue region along the plane.

Abstract: Various implementations directed to composite skid member with varying cross-sections are provided. In one implementation, an aircraft landing gear assembly may include two composite skid members configured to contact the ground, where each composite skid member includes a first cross-section and a second cross-section, and where the first cross-section is different than the second cross-section. The aircraft landing gear assembly may also include two cross members configured to couple to a fuselage of an aircraft and configured to interconnect the two composite skid members.

Abstract: A system (100) for handling sheets of flexible material comprises: a plurality of releasable connectors (20) supported on a main carrier (110). The releasable connectors (20) are individually addressable so that when actuated a connector lifts or releases a sheet of flexible material. One or more end adjustment means is provided to vary at least one of: the orientation and/or the location of the connectors (20), with respect to a surface defined in three dimensions, such that in use the sheet of flexible material is placed in a precise user selected position on the three dimensional surface without the material creasing or wrinkling. An advantage of the present invention is that previously actuators were able to orient grippers to be normal to the surface of a cylinder; whereas the provision of parallel, flexible strips enables active surfaces to be positioned normal to the surface of complex surface, such as that defined by a cone.