Abstract: The present invention relates nanoparticles formed of a polymer and an antifungal agent, wherein the polymer is selected from the group consisting of linear or branched or cyclic polymonoguanide/polyguanidine, polybiguanide, analogues or derivatives thereof, or mixtures thereof. The nanoparticles are particularly suited for the treatment of fungal nail or skin infections.

Abstract: Methods, systems, and platforms for generating and deploying an augmented reality (AR) experience using a decoupled content management system is described herein. A method for providing an AR experience can include selecting a plurality of digital content associated with the AR experience from a content database at a decoupled CMS, defining one or more triggering mechanisms for actuating the AR experience, selecting one or more augmented reality assets based on a selected media asset type, generating an AR bundle comprised of at least one of the selected plurality of digital content, the one or more triggering mechanisms and the one or more augmented reality assets, and publishing the AR bundle to an end user application.

Abstract: A device for imaging within a body of a patient is provided. In one embodiment, the device includes a flexible elongate member that can be inserted into the body of the patient. The device also has an imaging assembly that is disposed at and extending a length of a distal portion of the flexible elongate member. The imaging assembly may include an array of imaging elements that may have an outward surface and an inward surface. The imaging assembly may further include an integrated circuit adjacent to the inward surface of the array of imaging elements. The device may further include a conductive plate adjacent to and extending at least a portion of a length of the imaging assembly. The conductive plate may receive heat generated by at least one of the array of imaging elements or the integrated circuit.

Abstract: The present invention relates to compositions comprising constituents, derivatives or extracts of cannabis. The invention also relates to uses of such compositions and methods of manufacturing them.

Abstract: The present invention relates to compositions comprising active agents formulated for both buccal and gastric delivery wherein the composition also comprises one or more constituent, derivative or extract of cannabis and a further physiologically active agent.

Abstract: The present invention relates to compositions comprising one or more constituent, derivative or extract of cannabis formulated for gastric delivery and one or more flavour or sensate formulated for buccal delivery.

Abstract: A method for printing onto a substrate is disclosed. An ink is printed onto a liquid polymer layer to form a printed polymer layer. Printed substrates are also disclosed.

Abstract: Novel and unique medical devices and associated methods are disclosed, for a medical device for puncturing tissue at a tissue site. The medical device includes an elongate member having a distal section defining a distal section curved portion and a distal section straight portion. The distal section straight portion is distal to the distal section curved portion. An active tip is located at a distal end of the distal section. The active tip is operable to deliver energy to create a puncture through the tissue. The medical device includes a constant diameter layer. The distal section straight portion includes a minimum diameter portion located proximal to a constant diameter portion, and the constant diameter layer surrounds the minimum diameter portion.

Abstract: A method of real-time noise reduction including generating spectral data using temporally localized spectral representations of a received audio signal, determining detection of voice by comparing first and second filtered data, and generating noise-reduced audio output by attenuating noise based on the determined detection of voice. The first and second filtered data are formed by attenuating temporal variations of the spectral data based on, respectively, a first timescale and a second timescale. A noise reduction system, comprising processing circuitry configured to execute a method of real-time noise reduction to generate an output that is transmitted via an output port of the noise reduction system. A noise-reduction microphone comprising a housing having a transducer coupled to a processor therein to execute a method of real-time noise reduction, and an output port. A non-transitory computer-readable medium having instructions to cause a processor to perform a method of real-time noise reduction.

Abstract: In an embodiment a method for structuring a semiconductor surface includes providing the semiconductor surface, wherein the semiconductor surface is part of a GaN-semiconductor layer, irradiating the semiconductor surface with an electron beam in order to produce an irradiated section and anisotropic wet-chemical etching of the semiconductor surface, wherein an etching rate in the irradiated section is less than that in an unirradiated section of the semiconductor surface, and wherein no etching mask is applied to the semiconductor surface before anisotropic wet-chemical etching.

Abstract: Headgear for use with a respiratory mask can include a continuous and substantially curved elongate member extending in use below a user's nose and at least two headgear straps capable of attachment to the ends of the elongate member. A mask attachment on the elongate member is disposed to sit below or on one of said user's nose, mouth, upper lip and an inlet to the mask. The attachment is capable of receiving the mask.

Abstract: One or more embodiments of the present disclosure relate to switching between execution schedules related to execution of tasks, or runnables, by multiple compute engines. The execution schedules includes respective sets of commands that dictate timing and order of execution, by the compute engines, of tasks, or runnables, corresponding to computing applications.

Abstract: A cyber security system is adapted to generate a cloud architecture assembled from a plurality of cloud resources within a customer cloud environment based on metadata associated with the plurality of cloud resources. The cyber security system features at least a plurality of components. The first component identifies the plurality of cloud resources and collects metadata associated with each of the plurality of cloud resources including a first cloud resource for storage within a storage subsystem. The second component determines how at least the first cloud resource of the plurality of cloud resources is behaving within the customer cloud environment based on analytics conducted on log data and network traffic data associated with the first cloud resource. The third component conducts analytics on information associated with the plurality of cloud resources in order to detect compliance or misconfiguration of the plurality of cloud resources forming the cloud architecture.

Abstract: A projection system and calibration method therefor relate to a light source configured to emit a light in response to an image data, an illumination optical system configured to steer the light, the illumination optical system including a first mirror and a second mirror, a digital micromirror device (DMD) including a plurality of micromirrors respectively configured to reflect the steered light to a filter as on-state light or to reflect the steered light as off-state light to a light dump; determining a deviation between an actual angle of orientation and an expected angle of orientation of the DMD; calculating a first amount of angle adjustment corresponding to the first mirror and a second amount of angle adjustment corresponding to the second mirror; and actuating the first mirror according to the first amount and the second mirror according to the second amount.

Abstract: One or more embodiments of the present disclosure relate to executing, by a plurality of compute engines, a plurality of runnables of a computing application based at least on an execution schedule and a set of commands associated with the execution schedule. The execution schedule may be generated using a compiling system to include the set of commands. The set of commands may include one or more individual commands corresponding to one or more timing fences dictating a timing and order of execution of one or more individual runnables of the plurality of runnables.

Abstract: The present disclosure relates to a controller (20) for controlling operation of an access control device (2) for a vehicle (3). The access control device (2) is selectively operable in a first operating mode (P1) and a second operating mode (P2). The access control device (2) is in a limited response mode when operating in the first operating mode (P1). The controller (20) includes a processor (24) and a memory means (23). The processor (24) is configured to determine a position of the access control device (2) and to generate a control signal for activating the first operating mode (P1). The control signal is generated in dependence on the determined position of the access control device (2). The controller (20) may be provided in the access control device (2). The present disclosure also relates to a method of controlling operation of an access control device (2).

Abstract: The present invention relates to the area of improved anti-IgE antibodies and antigen binding agents, and compositions thereof, which target IgE, for instance: for use in treating disorders caused by IgE (such as allergic responses, or certain autoimmune responses); and, in particular, disorders caused by the interaction of IgE with the Fc?RI receptor. In particular, this invention relates to improved anti-IgE antibodies and antigen binding agents related to novel mutants of omalizumab (Xolair®). The improved anti-IgE antibodies and antigen binding agents of the invention may have improved affinity for IgE and/or an improved interaction with the C?2 domain of IgE and/or an improved modified epitope on IgE (for instance further involving the C?2 domain of IgE) and/or the ability to disassociate IgE from the Fc?RI receptor for instance at pharmaceutically-relevant concentrations.

Abstract: A system, a method, and a device are provided for detecting abnormalities in a tubular structure. In one aspect, an abnormality detection system may include a sensing array, a memory, and one or more processors arranged on a tubular structure. In an example, the sensing array may include plurality of optical sensors and plurality of acoustic sensors. The processors are configured to receive sensor data relating to a tubular structure from the sensing array. Further the processors are configured to determine properties of the tubular structure based on the sensor data, where the properties are associated with at least one of: material, or physical structure and detect an abnormality in the tubular structure based on the determined properties. Further the processors are configured to determine characteristics of the detected abnormality in the tubular structure.

Abstract: Systems and methods are provided for correcting distributed acoustic sensing (DAS) data. The system can receive a seismic dataset with a plurality of initial seismic phase picks and a plurality of traces, and cross-correlate each of the plurality of initial seismic phase picks using the plurality of traces as reference traces. Each initial seismic phase pick can receive a set of corrected phase picks. The system can calculate a probability density function for each set of corrected phase picks. The system can select a peak of each probability density functions as accurate seismic phase picks. These accurate seismic phase picks can be used for event location in the DAS data.

Abstract: A radiating spacer includes a plate body having a backing plate facing side and a caliper facing side, with the backing plate facing side having a plurality of cooling grooves and the caliper facing side having a planar caliper piston contact area. The cooling grooves extend partially into the plate body to provide additional cooling of the brake pad and braking assembly. The planar caliper piston contact area is configured to provide a flat surface for contact with a caliper piston. In some embodiments, the radiating spacer and the backing plate are made from different metal materials having certain thermal conductivity coefficients to help promote advantageous heat distribution.