Patents by Inventor John A. Frangos
John A. Frangos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20110224524Abstract: The present invention includes a method for sensing glucose in a mammal, which includes implanting an a sensor having a permeable membrane and a plurality of spaced apart patches of titanium dioxide disposed on the permeable membrane and sensing glucose in the mammal.Type: ApplicationFiled: May 20, 2011Publication date: September 15, 2011Inventors: LARS M. BJURSTEN, John A. Frangos
-
Patent number: 7943390Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.Type: GrantFiled: April 20, 2009Date of Patent: May 17, 2011Assignees: The Curators of the University of Missouri, The Regents of the University of California, La Jolla Bioengineering InstituteInventors: Mark A. Haidekker, Sheila Grant, Emmanuel Theodorakis, Marcos Intaglietta, John A. Frangos
-
Patent number: 7910221Abstract: Methods and compositions are disclosed for coating a biocompatible medical implant with a surface layer having antioxidant activity. In various embodiments, a surface layer described herein destroys the oxidative activity of a reactive oxygen species (ROS) upon contact. An ROS can be, for example, an ROS generated by neutrophils in vivo. In various embodiments, a surface layer comprises a titanium oxide layer that can comprise a rutile, an anatase or a perovskite crystal structure, and can include defects comprising Ti(III). In some embodiments, the oxide layer can further comprise a dopant such as niobium. In some embodiments, methods for forming a surface layer on a biocompatible medical implant having antioxidant activity are disclosed.Type: GrantFiled: February 8, 2007Date of Patent: March 22, 2011Assignee: La Jolla Bioengineering InstituteInventors: Ramiro Contreras, Herman Sahlin, John A. Frangos
-
Patent number: 7670844Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.Type: GrantFiled: January 20, 2005Date of Patent: March 2, 2010Assignees: The Curators of the University of Missouri, The Regents of the University of California, La Jolla Bioengineering InstituteInventors: Mark A. Haidekker, Sheila Grant, Emmanuel Theodorakis, Marcos Intaglietta, John A. Frangos
-
Publication number: 20090292191Abstract: The present invention includes a method for implanting a cardiac pacemaker. The cardiac pacemaker has leads with a plurality of spaced apart patches disposed on the leads, each patch having a distance of separation from its nearest adjacent patch of about 10 nm to about 10 ?m. The invention also includes a method for sensing glucose in a mammal, which includes implanting an a sensor having a permeable membrane and a plurality of spaced apart patches of titanium dioxide disposed on the permeable membrane and sensing glucose in the mammal.Type: ApplicationFiled: May 29, 2009Publication date: November 26, 2009Inventors: Lars M. Bjursten, John A. Frangos
-
Publication number: 20090227880Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.Type: ApplicationFiled: April 20, 2009Publication date: September 10, 2009Applicant: THE CURATORS OF THE UNIVERSITY OF MISSOURIInventors: Mark A. Haidekker, Sheila Grant, Emmanuel Theodorakis, Marcos Intaglietta, John A. Frangos
-
Patent number: 7547471Abstract: The present invention relates to a material for implantation, which is characterised in that the surface of the material partially comprises at least one area of an inorganic, catalytical substance for improved biocompatibility of the material. Methods for the manufacturing of the material for implantation and the use thereof is also disclosed.Type: GrantFiled: January 31, 2003Date of Patent: June 16, 2009Assignee: La Jolla Bioengineering InstituteInventors: Lars M. Bjursten, John A. Frangos
-
Patent number: 7439057Abstract: The present invention provides for an improved in vitro tissue assembly system and related methods that includes and uses a bioreactor, a porous mandrel disposed in the bioreactor, and components that provide for the circulation of culture media and cell suspensions within the bioreactor and through the porous mandrel. The circulation of the culture media and cell suspensions within the bioreactor produces a radial, convective flow and drag forces that result in the deposition of cells on the mandrel to form a tissue construct. Upon completion of the culture and tissue formation process, the tissue construct may be removed from the mandrel for subsequent in vivo use.Type: GrantFiled: November 16, 2004Date of Patent: October 21, 2008Assignee: La Jolla Bioengineering InstituteInventors: John A. Frangos, Peter Sobolewski
-
Publication number: 20070191944Abstract: Methods and compositions are disclosed for coating a biocompatible medical implant with a surface layer having antioxidant activity. In various embodiments, a surface layer described herein destroys the oxidative activity of a reactive oxygen species (ROS) upon contact. An ROS can be, for example, an ROS generated by neutrophils in vivo. In various embodiments, a surface layer comprises a titanium oxide layer that can comprise a rutile, an anatase or a perovskite crystal structure, and can include defects comprising Ti(III). In some embodiments, the oxide layer can further comprise a dopant such as niobium. In some embodiments, methods for forming a surface layer on a biocompatible medical implant having antioxidant activity are disclosed. These methods include subjecting a surface comprising titanium to anodic spark deposition (ASD).Type: ApplicationFiled: February 8, 2007Publication date: August 16, 2007Applicant: La Jolla Bioengineering InstituteInventors: Ramiro Contreras, Herman Sahlin, John Frangos
-
Publication number: 20060105452Abstract: The present invention provides for an improved in vitro tissue assembly system and related methods that includes and uses a bioreactor, a porous mandrel disposed in the bioreactor, and components that provide for the circulation of culture media and cell suspensions within the bioreactor and through the porous mandrel. The circulation of the culture media and cell suspensions within the bioreactor produces a radial, convective flow and drag forces that result in the deposition of cells on the mandrel to form a tissue construct. Upon completion of the culture and tissue formation process, the tissue construct may be removed from the mandrel for subsequent in vivo use.Type: ApplicationFiled: November 16, 2004Publication date: May 18, 2006Inventors: John Frangos, Peter Sobolewski
-
Publication number: 20060084177Abstract: A device and a method for measuring viscosity that includes attaching molecular rotors to a solid surface, exposing the solid surface to a fluid having a viscosity to be measured, and taking optical measurements to determine viscosity. The solid surface is preferably quartz, polystyrene or silicate glass, such as a fiber optic probe or a glass cuvette. The molecular rotors are of the type that includes an electron-donor group and electron-acceptor group that are linked by a single bond so that the groups may rotate with respect to one another, and that exhibit a fluorescence emission when rotation is hindered.Type: ApplicationFiled: January 20, 2005Publication date: April 20, 2006Inventors: Mark Haidekker, Sheila Grant, Emmanuael Theodorakis, Marcos Intaglietta, John Frangos
-
Publication number: 20050074602Abstract: The present invention relates to a material for implantation, which is characterised in that the surface of the material partially comprises at least one area of an inorganic, catalytical substance for improved biocompatibility of the material. Methods for the manufacturing of the material for implantation and the use thereof is also disclosed.Type: ApplicationFiled: January 31, 2003Publication date: April 7, 2005Inventors: Lars Bjursten, John Frangos
-
Patent number: 5730321Abstract: The invention relates to methods, compositions and apparatuses, such as squirt guns and of the water emitting devices, that eject a flow of aqueous fluid having visible bioluminescence, providing "glow-in-the dark" emissions. The devices contain a population of a mechanical stress-stimulatable bioluminescent organisms, such as Pyrocystis species such as lunula and fusiformis, in suspension in a fluid. The fluid luminesces when ejected from an aperture of the device. The devices may also include a fluid flow generator, such as a mechanical pump, capable of inducing the flow of the fluid through the flow path and a trigger or valve capable of activating said fluid flow generator. In addition, the invention provides containers for viably storing populations of the bioluminescent organisms, methods and media for culturing and diluting the organisms, and kits of an emitter, a storage apparatus, suitable bioluminescent organisms, and culture media.Type: GrantFiled: December 13, 1995Date of Patent: March 24, 1998Inventors: Todd McAllister, John Frangos, Michael Latz