Patents by Inventor John A. Gaudette
John A. Gaudette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11413243Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: GrantFiled: November 6, 2018Date of Patent: August 16, 2022Assignee: Nitto Denko CorporationInventors: Kwok Yin Tsang, Bharat Majeti, John Gaudette, Roger Adami, Hao Bai, Wenbin Ying
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Publication number: 20220242820Abstract: Ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, the compounds, compositions and methods are to provide nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: ApplicationFiled: April 5, 2022Publication date: August 4, 2022Inventors: Roger Adami, Hao Bai, John Gaudette, Bharat Majeti, Seiji Nukui, Kwok Yin Tsang, Hai Wang, Haiqing Yin, Wenbin Ying
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Publication number: 20220233445Abstract: Fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, compounds, compositions and methods are to provide nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: ApplicationFiled: April 5, 2022Publication date: July 28, 2022Inventors: Kwok Yin Tsang, Bharat Majeti, John Gaudette, Roger Adami, Hao Bai, Wenbin Ying
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Patent number: 11384051Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: GrantFiled: December 20, 2018Date of Patent: July 12, 2022Assignee: Nitto Denko CorporationInventors: Roger Adami, Hao Bai, John Gaudette, Bharat Majeti, Seiji Nukui, Kwok Yin Tsang, Hai Wang, Haiqing Yin, Wenbin Ying
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Patent number: 11364200Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: GrantFiled: November 6, 2018Date of Patent: June 21, 2022Assignee: Nitto Denko CorporationInventors: Kwok Yin Tsang, Bharat Majeti, John Gaudette, Roger Adami, Hao Bai, Wenbin Ying
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Patent number: 11318099Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: GrantFiled: November 6, 2018Date of Patent: May 3, 2022Assignee: Nitto Denko CorporationInventors: Kwok Yin Tsang, Bharat Majeti, John Gaudette, Roger Adami, Hao Bai, Wenbin Ying
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Patent number: 11103583Abstract: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.Type: GrantFiled: July 2, 2019Date of Patent: August 31, 2021Assignee: Nitto Denko CorporationInventors: Joseph E. Payne, John A. Gaudette, Zheng Hou, Mohammad Ahmadian, Lei Yu, Victor Knopov, Violetta Akopian, Priya Karmali, Richard P. Witte, Neda Safarzadeh, Wenbin Ying, Jun Zhang
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Patent number: 11084779Abstract: Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z? is a counterion.Type: GrantFiled: December 2, 2019Date of Patent: August 10, 2021Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Zheng Hou, John A. Gaudette, Violetta Akopian, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Priya Karmali, Sridhar C. Nagarajan
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Patent number: 10961181Abstract: Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z? is a counterion.Type: GrantFiled: December 2, 2019Date of Patent: March 30, 2021Assignee: NITTO DENKO CORPORATIONInventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Zheng Hou, John A. Gaudette, Violetta Akopian, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Priya Karmali, Sridhar C. Nagarajan
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Publication number: 20200199064Abstract: Here described is a composition comprising a compound of formula I: wherein R1 and R2 is independently selected from a group consisting of C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl group; R3 and R4 are independently selected from a group consisting of C1 to C6 alkyl, and C2 to C6 alkanol; X is selected from a group consisting of —CH2—, —S—, and —O— or absent; Y is selected from —(CH2)n, —S(CH2)n, —O(CH2)n—, thiophene, —SO2(CH2)n—, and ester; n=1-4; a=1-4; b=1-4; c=1-4; and Z? is a counterion.Type: ApplicationFiled: December 2, 2019Publication date: June 25, 2020Inventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Zheng Hou, John A. Gaudette, Violetta Akopian, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Priya Karmali, Sridhar C. Nagarajan
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Patent number: 10669229Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.Type: GrantFiled: May 21, 2018Date of Patent: June 2, 2020Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Joseph E. Payne, John A. Gaudette, Zheng Hou, Victor Knopov, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Violetta Akopian
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Publication number: 20200085957Abstract: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.Type: ApplicationFiled: July 2, 2019Publication date: March 19, 2020Inventors: Joseph E. Payne, John A. Gaudette, Zheng Hou, Mohammad Ahmadian, Lei Yu, Victor Knopov, Violetta Akopian, Priya Karmali, Richard P. Witte, Neda Safarzadeh, Wenbin Ying, Jun Zhang
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Patent number: 10532975Abstract: Here described is a method of delivery of a drug to a stellate cell using a composition comprising a compound of formula I: wherein R1 and R2 are independently selected from C10 to C18 alkyl, C12 to C18 alkenyl, and oleoyl; R3 and R4 are independently selected from C1 to C6 alkyl and C2 to C6 alkanol; X is selected from —CH2—, —S—, and —O—, or X is absent; Y is selected from —(CH2)n, —S(CH2)n—, —O(CH2)n—, -thiophene-, —SO2(CH2)n—, and ester; n?1-4; a?1-4; b?1-4; c?1-4; and Z? is a counterion.Type: GrantFiled: March 12, 2018Date of Patent: January 14, 2020Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Zheng Hou, John A. Gaudette, Violetta Akopian, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Priya Karmali, Sridhar C. Nagarajan
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Patent number: 10441659Abstract: The description is directed to ionizable lipids useful for enhancing the delivery of therapeutic agents in liposomes.Type: GrantFiled: October 1, 2015Date of Patent: October 15, 2019Assignee: Nitto Denko CorporationInventors: Joseph E. Payne, John A. Gaudette, Zheng Hou, Mohammad Ahmadian, Lei Yu, Victor Knopov, Violetta Akopian, Priya Karmali, Richard P. Witte, Neda Safarzadeh, Wenbin Ying, Jun Zhang
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Publication number: 20190133948Abstract: This invention includes fusogenic compounds, and compositions and methods of use thereof. The fusogenic compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to incorporate or encapsulate active agents, to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: ApplicationFiled: November 6, 2018Publication date: May 9, 2019Inventors: Kwok Tsang, Bharat Majeti, John Gaudette, Roger Adami, Hao Bai, Wenbin Ying
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Publication number: 20190127318Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: ApplicationFiled: December 20, 2018Publication date: May 2, 2019Inventors: Roger Adami, Hao Bai, John Gaudette, Bharat Majeti, Seiji Nukui, Kwok Yin Tsang, Hai Wang, Haiqing Yin, Wenbin Ying
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Patent number: 10196637Abstract: What is described is a pharmaceutical composition for treating a fibrotic disease comprising a drug carrier, which comprises a lipid and a retinoid, and a double-stranded nucleic acid molecule, which comprises an antisense sequence to mRNA encoding human hsp47.Type: GrantFiled: October 3, 2016Date of Patent: February 5, 2019Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Victor Knopov, Joseph E. Payne, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Violetta Akopian, Yasunobu Tanaka, Elena Feinstein, Sharon Avkin-Nahum, Hagar Kalinski, Igor Mett, Kenjiro Minomi, Wenbin Ying, Yun Liu, Zheng Hou, John A. Gaudette, Priya Karmali, Sridhar C. Nagarajan
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Patent number: 10167253Abstract: This invention includes ionizable compounds, and compositions and methods of use thereof. The ionizable compounds can be used for making nanoparticle compositions for use in biopharmaceuticals and therapeutics. More particularly, this invention relates to compounds, compositions and methods for providing nanoparticles to encapsulate active agents, such as nucleic acid agents, and to deliver and distribute the active agents to cells, tissues, organs, and subjects.Type: GrantFiled: June 23, 2016Date of Patent: January 1, 2019Assignee: Nitto Denko CorporationInventors: Roger Adami, Hao Bai, John Gaudette, Bharat Majeti, Seiji Nukui, Kwok Yin Tsang, Hai Wang, Haiqing Yin, Wenbin Ying
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Publication number: 20180297938Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.Type: ApplicationFiled: May 21, 2018Publication date: October 18, 2018Inventors: Yoshiro Niitsu, Joseph E. Payne, John A. Gaudette, Zheng Hou, Victor Knopov, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Violetta Akopian
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Patent number: 10100004Abstract: Here described are compounds consisting of the structure (targeting molecule)m-linker-(targeting molecule)n, wherein the targeting molecule is a retinoid or a fat soluble vitamin having a specific receptor on the target cell; wherein m and n are independently 0, 1, 2 or 3; and wherein the linker comprises a polyethylene glycol (PEG) or PEG-like molecule, as well as compositions and pharmaceutical formulations including these compounds which are useful for the targeting and delivery of therapeutic agents; and methods of using these compositions and pharmaceutical formulations.Type: GrantFiled: June 8, 2016Date of Patent: October 16, 2018Assignee: Nitto Denko CorporationInventors: Yoshiro Niitsu, Joseph E. Payne, John A. Gaudette, Zheng Hou, Victor Knopov, Richard P. Witte, Mohammad Ahmadian, Loren A. Perelman, Yasunobu Tanaka, Violetta Akopian