Abstract: Metering structure includes a rigid strut configured to support an optical element. A rigid shield mounted on the strut has a shield length which is substantially coextensive with the elongated length of the rigid strut such that rigid shield substantially encloses the strut along the entire shield length. The rigid shield has a surface finish which is highly absorptive of electromagnetic radiation in the optical spectrum. One or more thermal insulating material layers comprise a multi-layer insulation (MLI) system disposed between the rigid strut and the rigid shield. Rigid and flexure brackets secure the rigid shield to the strut.

Abstract: The invention is related to the preparation of protected piperidine carboxylates suitable for use as intermediates that lead, via a series of additional process steps, including a sulfation of a hydroxy urea compound, to the preparation of the beta lactamase inhibitor (2S,5R)-7-oxo-N-piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide.

Abstract: An ultrasound probe for percutaneous insertion into an incision and related methods are disclosed herein, e.g., for imaging neural structures at a surgical site of a patient. An exemplary ultrasound probe can be a portable ultrasound probe configured to be passed percutaneously into an incision and can have an imaging region extending distally from a distal tip of the probe. In one embodiment the ultrasound probe can be a navigated portable ultrasound probe. The ultrasound probe can be connected to a computing station and configured to transmit images to the computing station for processing. In another embodiment, an ultrasound probe can be part of a network of sensors, including at least one external sensor, where the network of sensors is configured to transmit images to the computing station for processing. The computing station can process and display images to visualize and/or highlight neurological structures in an imaged region.

Abstract: Metering structure includes a rigid strut configured to support an optical element. A rigid shield mounted on the strut has a shield length which is substantially coextensive with the elongated length of the rigid strut such that rigid shield substantially encloses the strut along the entire shield length. The rigid shield has a surface finish which is highly absorptive of electromagnetic radiation in the optical spectrum. One or more thermal insulating material layers comprise a multi-layer insulation (MLI) system disposed between the rigid strut and the rigid shield. Rigid and flexure brackets secure the rigid shield to the strut.

Abstract: A patient interface includes a hollow base with an air inlet configured to be connected to an air delivery tube and receive the pressurized flow of respiratory gas. The hollow base further includes a pair of nozzles extending from the hollow base. Each nozzle is configured to receive the pressurized flow of respiratory gas from a respective one of the pair of air outlets. A continuous flexible adhesive strip of material configured to adhere to a side of the patient's nose and support the hollow base and the pair of nozzles on the patient's face to form a sealed airpath from the hollow base to the patient's nasal airways. The hollow base comprises a first portion from which the pair of nozzles extend and a second portion that is attachable to the air delivery tube. The second portion is more rigid than the first portion.

Abstract: A patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to the patient's airways including at least entrance of a patient's nares to ameliorate sleep disordered breathing may include a seal-forming structure comprising a foam undercushion and a textile membrane for contact with the patient's face; a positioning and stabilising structure to maintain the seal-forming structure in sealing contact with an area surrounding an entrance to the patient's airways while maintaining a therapeutic pressure at the entrance to the patient's airways; and a plenum chamber pressurised at a pressure above ambient pressure in use.

Abstract: A beverage dispenser maintains a profile queue with profile data of “close” consumer mobile computing devices. Each profile in the profile queue maintains one or more beverages previously selected by a consumer, such as favorite beverage(s), mixed or blended beverages, and/or past or future beverage order(s). Each profile in the profile queue is additionally associated with a profile identifier, such as a name, screen name, social media picture, avatar, alphanumeric identifier, other such text or graphics recognizable by a consumer to be associated with their corresponding profile. Upon navigation to an appropriate screen on the beverage dispenser, a display on the beverage dispenser shows the profile identifiers or one or more of the previously selected beverages in the profiles of “close” consumer mobile computing devices. In this way, a consumer is able to quickly access their previously selected beverages without actively manipulating their mobile device.

Abstract: The following relates generally to determining and/or displaying home scores. In some embodiments, one or more processors: (1) receive imagery data; (2) determine a new device based upon the imagery data; (3) determine a home score improvement that adding the new device to the home would make for the overall home score, the home safety subscore, the fire protection subscore, the sustainability subscore, and/or the home automation subscore; and/or (4) display the home score improvement on a display.

Abstract: The following relates generally to determining and/or displaying home scores. In some embodiments, one or more processors: (1) display, in a first portion of a display, identifying information of a home; and (2) display, in a second portion of the display: (a) an overall home score determined based upon a plurality of home subscores; (b) the plurality of home subscores comprising: a home safety subscore determined via a home safety subscore machine learning algorithm, a fire protection subscore determined via a fire protection subscore machine learning algorithm, a sustainability subscore determined via a sustainability subscore machine learning algorithm, and/or a home automation subscore determined via a home automation subscore machine learning algorithm; and (c) a relative home score comprising a comparison between the overall home score and scores of other homes.

Abstract: The following relates generally to determining and/or displaying home scores. In some embodiments, one or more processors: (1) identify an upgrade and/or service to a home; (2) determine a home score improvement that the upgrade and/or service would make for an overall home score, a home safety subscore, a fire protection subscore, a sustainability subscore, and/or a home automation subscore; and/or (3) display the home score improvement along with an indication of the upgrade and/or service on a display.

Abstract: Systems and methods disclosed herein relates generally to using virtual reality (VR) for creating a digital twin of a home. In some embodiments, image data of a structure and an indication of a modification may be received, a virtual reality (VR) feed including a virtual representation of the modification proximate the structure may be generated, and the VR feed may be provided for presentation to a user within a VR display.

Abstract: The following relates generally to determining and/or displaying home scores. In some embodiments, one or more processors: (1) determine at least one of an overall home score, a home safety subscore, a fire protection subscore, a sustainability subscore, and/or a home automation subscore for a home; (2) identify a device; (3) determine a home score improvement that adding the device to the home would make for the overall home score, the home safety subscore, the fire protection subscore, the sustainability subscore, and/or the home automation subscore; and/or (4) display the home score improvement on a display, and/or otherwise visually, graphically, textually, audibly, or verbally outputting the home score improvement, such as via a processor, screen, voice bot, chatbot, or other bot.

Abstract: Presented herein are techniques for monitoring the insertion of an intra-cochlear stimulating assembly for the occurrence of one or more insertion stop conditions. The insertion stop conditions are detectable events indicating that movement of the stimulating assembly into a recipient's cochlea should be at least temporarily stopped. The insertion monitoring is based on objectively measured inner ear potentials, such as acoustically-evoked potentials.

Abstract: Presented herein are techniques that make use of objective measurements obtained in response to acoustic stimulation signals. More specifically, at least one measure of outer hair cell function and at least one measure of auditory nerve function are obtained from a tonotopic region of an inner ear of a recipient of a hearing prosthesis. The at least one measure of auditory nerve function and the least one measure of outer hair cell function are then analyzed relative to one another.

Abstract: A method comprising determining a sleep state of a test subject using input data from the test subject. The input data comprise: at least one measure of test subject movement; and at least one cardiorespiratory feature of the test subject and are derived from video images of the test subject. The at least one cardiorespiratory feature of the test subject is derived using a feature extractor trained using reference cardiorespiratory signals for each of a plurality of reference subjects derived from time-resolved measurements from a plurality of sensors worn by the reference subjects, the feature extractor comprising a neural network, and the reference cardiorespiratory signals. Also provided a method of training a machine-learning algorithm to determine a sleep state of a subject using training data in respect of a plurality of training subjects derived from video images of the training subjects using the feature extractor.

Abstract: Presented herein are techniques for monitoring a recipient's cochlea health via a photoplethysmography (PPG) sensor to proactively identify (i.e., predict) changes to the recipient's cochlea health outside of a clinical setting. The cochlea health monitoring techniques presented herein obtain, via either an external or implanted PPG sensor, one or more cardiovascular health biomarkers associated with a recipient's cochlea health, and analyze these biomarkers to predict that a recipient health change is likely to occur.

Abstract: A patient interface for sealed delivery of a flow of air at a continuously positive pressure with respect to ambient air pressure to an entrance to the patient's airways including at least entrance of a patient's nares to ameliorate sleep disordered breathing may include a seal-forming structure comprising a foam undercushion and a textile membrane for contact with the patient's face; a positioning and stabilising structure to maintain the seal-forming structure in sealing contact with an area surrounding an entrance to the patient's airways while maintaining a therapeutic pressure at the entrance to the patient's airways; and a plenum chamber pressurised at a pressure above ambient pressure in use.

Abstract: A beverage dispenser and method for operating a beverage dispenser may include receiving a handshake request from a mobile device of a user. A communications link may be established with the mobile device. Responsive to receiving control data associated with a beverage order from the mobile device, a physical function may be caused to be performed by the beverage dispenser.

Abstract: The present disclosure relates to compounds of Formula (I): and to their prodrugs, pharmaceutically acceptable salts, pharmaceutical compositions, methods of use, and methods for their preparation. The compounds disclosed herein are useful for modulating orexin-2 receptor activity and may be used in the treatment of disorders in which orexin-2 receptor activity is implicated, such as a neurodegenerative disorder, a symptom of a rare genetic disorder, a mental health disorder, a metabolic syndrome, osteoporosis, cardiac failure, coma, or a complication in emergence from anaesthesia.

Abstract: A push-in catalyst assembly for a home cooking appliance, and a home cooking appliance having a push-in catalyst assembly, are provided. The push-in catalyst assembly includes a body configured to support a catalytic material, the body having a distal end and a proximal end, a flange extending from a region of the proximal end of the body and configured to abut an inner surface of a wall of the cooking compartment, and a plurality of locking spring tabs extending outward from the body. The locking spring tabs have an end portion spaced from the flange by a predetermined distance. The flange and the end portion of each of the locking spring tabs are configured to secure the wall of the cooking compartment therebetween without a fastener.