Patents by Inventor John A. Goetz

John A. Goetz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for diagnosing non-small cell lung carcinoma
    Patent number: 8273701
    Abstract: The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.
    Type: Grant
    Filed: August 14, 2006
    Date of Patent: September 25, 2012
    Assignee: Trustees of Dartmouth College
    Inventors: David J. Robbins, Ziqiang Yuan, John A. Goetz
  • METHOD FOR THE ANALYSIS OF O-LINKED OLIOSACHARIDES
    Publication number: 20110143386
    Abstract: A method of analyzing O-linked oligosaccharides in a sample is disclosed. The method comprises the steps of digesting a glycoprotein with a proteolytic enzyme, performing solid-phase permethylation of the oligosaccharide, then analyzing the permethylated and non-reduced O-linked oligosaccharides using MALDI-TOF mass spectrometry.
    Type: Application
    Filed: August 11, 2009
    Publication date: June 16, 2011
    Applicant: Indiana University Research and Technology Corpora
    Inventors: Yehia S. Mechref, Milos V. Novotny, John A. Goetz
  • Method for Diagnosing Non-Small Cell Lung Carcinoma
    Publication number: 20100029580
    Abstract: The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.
    Type: Application
    Filed: April 12, 2006
    Publication date: February 4, 2010
    Inventors: David J. Robbins, Ziqiang Yuan, John A. Goetz
  • Soluble, freely diffusible Sonic hedgehog protein
    Publication number: 20030162227
    Abstract: Isolated native forms of soluble, freely diffusible Sonic hedgehog protein and recombinant forms of soluble, freely diffusible oligomeric Sonic hedgehog protein are produced. Methods of assaying an oligomeric Sonic hedgehog protein derived from a tissue and/or cell comprise measuring a conditioned media to detect the production of the soluble, freely diffusible Sonic hedgehog protein.
    Type: Application
    Filed: February 28, 2003
    Publication date: August 28, 2003
    Inventors: David J. Robbins, John A. Goetz, Xin Zeng