Abstract: A valving arrangement is provided herein for regulating fluidics of modules usable in a combinatorial drug delivery device. The valving includes a slidable piston valve, adjustable to selectively seal an outlet path from a drug vial and a sealing port, in parallel to a vent, for selectively sealing an inlet path to the drug vial. Advantageously, the subject invention allows for applied negative pressure to adjust the valving to allow flow between serially-connected modules forming a drug delivery device.

Abstract: An antenna array is provided having multiple antenna elements mountable to the roof of a locomotive. Each of the antenna elements has a separate signal path of one or more conductive elements in a housing and shares a common hole or opening to outside the housing through which the signal path of each antenna element is extendable. The signal path of each antenna element then extends via a common access hole in the roof of the locomotive for enabling one or more of passage of signals to or from the antenna element. The access hole is below the array when the common hole is along the bottom of the housing, and elsewhere along the roof when the common hole is along a side of the housing. Two of the antenna arrays may be mounted in a parallel relationship spaced from each other along the locomotive roof and share the same or a different access hole in such roof.

Abstract: An antenna array is provided having multiple antenna elements mountable to the roof of a locomotive. Each of the antenna elements has a separate signal path of one or more conductive elements in a housing and shares a common hole or opening to outside the housing through which the signal path of each antenna element is extendable. The signal path of each antenna element then extends via a common access hole in the roof of the locomotive for enabling one or more of passage of signals to or from the antenna element. The access hole is below the array when the common hole is along the bottom of the housing, and elsewhere along the roof when the common hole is along a side of the housing. Two of the antenna arrays may be mounted in a parallel relationship spaced from each other along the locomotive roof and share the same or a different access hole in such roof.

Abstract: An antenna array is provided having multiple antenna elements mountable to the roof of a locomotive. Each of the antenna elements has a separate signal path of one or more conductive elements in a housing and shares a common hole or opening to outside the housing through which the signal path of each antenna element is extendable. The signal path of each antenna element then extends via a common access hole in the roof of the locomotive for enabling one or more of passage of signals to or from the antenna element. The access hole is below the array when the common hole is along the bottom of the housing, and elsewhere along the roof when the common hole is along a side of the housing. Two of the antenna arrays may be mounted in a parallel relationship spaced from each other along the locomotive roof and share the same or a different access hole in such roof.

Abstract: A tri-band antenna (10) is provided having a pair of antenna elements (12, 14), in which the first antenna element (14) operates in a first UHF frequency band, and the second antenna element (12) operates in a second VHF band and a third cellular frequency band. The bottom end (12a, 14a) of each of the antenna elements (12, 14) is fixed into a first member (16) from which the antenna elements extend parallel and spaced apart from each other to their different respective heights. A second member (13) couples the antenna elements (12, 14) to each other at a distance from the first member (16) to adjust the operation of the tri-band antenna (10) in at least the UHF band. A base member (19) is provided for mounting the tri-band antenna (10) along a surface of a vehicle. A signal feed member (20) extends through the base member (19) and has one end (20a) attached to the first member (16) and another end (20b) providing a RF connector.

Abstract: A tri-band antenna is provided having a pair of antenna elements, in which the first antenna element operates in a UHF band, and the second antenna element operates in VHF and cellular bands. The antenna elements are fixed into a first member from which the antenna elements extend parallel and spaced apart from each other to their different respective heights. A second member couples the antenna elements to each other at a distance from the first member to adjust at least the UHF band. A base member is provided for mounting the tri-band antenna on a vehicle. A signal feed member extends through the base member and has one end attached to the first member and another end providing a RF connector. The signal feed member provides the antennal elements, via the first member, with a common signal path for transmission and reception of RF signals in all three bands.

Abstract: The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.

Abstract: A method of analyzing O-linked oligosaccharides in a sample is disclosed. The method comprises the steps of digesting a glycoprotein with a proteolytic enzyme, performing solid-phase permethylation of the oligosaccharide, then analyzing the permethylated and non-reduced O-linked oligosaccharides using MALDI-TOF mass spectrometry.

Abstract: The present invention relates to the constitutive activity of the Hedgehog pathway in non-small cell lung carcinoma (NSCLC). A method for diagnosing NSCLC by detecting the level of a component of the Hedgehog pathway is provided, as is a method for identifying subjects that will respond positively to treatment with a Hedgehog pathway antagonist. Methods for treating subjects with cancer or cancers resistant to Hedgehog pathway antagonists are also provided.

Abstract: The present invention relates to abrasive composites having improved abrasive particle retention due to unique coating designs. The present invention describes coated abrasive particles having tortuous surface topography, a process for producing such coated abrasive particles, and products comprising such coated abrasive particles. The coated abrasive particles have an outer layer coating with highly tortuous surface comprising about 5 spikes and have a tortuosity of at least about 1.1. The coated abrasive particles may be used in composites including metal/metal alloy matrix composites, ceramic/glass matrix composites, and polymer based matrix composites.

Abstract: The present invention relates to the use of sonic hedgehog antagonists in the prevention and treatment of cancer and other hyperproliferative diseases or disorders. Methods for identifying such antagonists are also provided.

Abstract: A method for preparing coated diamond particles comprising the steps of coating the diamond particles with nickel in the presence of a reducing agent having a pH ranging of from about 6 to 10, and recovering the diamond particles coated with nickel/boron (Ni/B) wherein the Ni/B coating contains less than about 5 wt-% boron content. Coated diamond particles are used in abrasive tools/cutting elements such as grinding wheels, saw segments, drill bits and the like.

Abstract: Isolated native forms of soluble, freely diffusible Sonic hedgehog protein and recombinant forms of soluble, freely diffusible oligomeric Sonic hedgehog protein are produced. Methods of assaying an oligomeric Sonic hedgehog protein derived from a tissue and/or cell comprise measuring a conditioned media to detect the production of the soluble, freely diffusible Sonic hedgehog protein.