Abstract: This invention and relates to polynucleotide and polypeptide sequences of the Early Onset Alzheimer's Disease gene (herein "EOAD gene"). More particularly, this invention relates to fragments and mutants EOAD gene useful as probes and amplification primers for the identification of a predisposition or diagnosis of Alzheimer's Disease.

Abstract: The invention provides novel mutant S182 sequences, methods of diagnosing Alzheimer's disease using these novel mutant S182 genes, a model system for Alzheimer's disease comprising a mutant S182 gene, and methods of identifying mutations in genes homologous to the S182 gene.

Abstract: A method of preparing a transgenic animal model with enhanced, accelerated pathology for Alzheimer's Disease (AD) and the transgenic animal made by the method is disclosed. The method includes producing an F.sub.1 generation by crossing a first and second transgenic parent each carrying a different expressible transgene for differing aspects of the same desired phenotype associated with AD pathology. The offspring of the F.sub.1 generation are then screened and those which carry a transgene from each parental transgenic animal resulting in an enhanced pathology for Alzheimer's Disease are selected. In a preferred embodiment the AD-associated pathology is for amyloid accumulation. In an embodiment a mutant presenilin transgene and a transgene for a mutant amyloid precursor protein are used.

Abstract: In order to provide a block (1) of solid fuel material which has good burning time, good flame form and a clean flame, the block (1) is comprised of a mixture of solid particulate, cellulosic, organic combustible material, and stearic or palmitic acid together with, optionally, one or more fatty acids or esters. The mixture has a density of from 0.94 to 1.01 gm/cc. The block (1) has a slit (2) extending longitudinally of the block. The slot (2) communicates with a space (3). Combustible gases collect in the space (3) and form a flame at the mouth of the slit (2).