Patents by Inventor John A. Heit

John A. Heit has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150218648
    Abstract: The present invention relates to methods for diagnosing breast cancer; methods for assigning risk of reoccurrence of breast cancer; methods for assigning risk of mortality due to breast cancer, methods of monitoring breast cancer; methods of staging breast cancer; and various devices and kits adapted to perform such methods. These methods comprise measurement gene expression from one or more protein fatty acyl transferase genes in a tissue sample, and preferably in a tumor sample, from the patient.
    Type: Application
    Filed: August 1, 2013
    Publication date: August 6, 2015
    Inventors: Luc Gerard Berthiaume, Ryan John Heit
  • Publication number: 20120058484
    Abstract: This document provides methods and materials involved in assessing a mammal (e.g., a human) for a susceptibility to develop venous thromboembolism. For example, methods and materials for using a genetic variation in an ABO nucleic acid (e.g., rs2519093) to assess an individual's risk for developing venous thromboembolism are provided.
    Type: Application
    Filed: September 1, 2011
    Publication date: March 8, 2012
    Inventor: John A. Heit
  • Patent number: 6451526
    Abstract: The invention involves methods and materials for detecting a mutation in the genome of an organism. Specifically, the invention provides compositions of oligonucleotides and diagnostic kits that can be used to amplify nucleic acid sequences such that if heterologous amplified fragments are present, then stable nucleic acid branching structures are formed and detected from a cell lysate mixture containing the amplified nucleic acid. The formation of stable nucleic acid branching structures is particularly useful for providing a mechanism to detect heterologous alleles verses homozygous alleles since homozygous amplified products do not form stable nucleic acid branching structures. In addition, the invention provides methods of detecting heterologous Factor V alleles as well as homozygous wild-type and homozygous mutant Factor V alleles.
    Type: Grant
    Filed: January 15, 1999
    Date of Patent: September 17, 2002
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Lu Song, Dennis J. O'Kane, Kelly L. Krajnik, John A. Heit