Abstract: A method of cryopreservation of biological material includes the steps of providing an apparatus including a vessel having a reservoir wherein the vessel has a channel formed in a portion of the reservoir, the channel including an intermediate restriction dimensioned to resist passage of the biological material but allow passage of liquid treatment solutions, and the channel including sub-reservoirs at either end of the restriction; introducing the biological material into a reservoir region of the apparatus for capture in a channel region of the vessel; irrigating and draining the biological material with a series of vitrification solutions introduced into a first of the sub-reservoirs and removed from a second of the sub-reservoirs; final draining the irrigation solutions from the vessel; and vitrifying the vessel and captive biological material.

Abstract: A hybrid pressure and flowguage regulator apparatus includes a regulator body, an inlet, and an outlet assembly. The outlet assembly includes a first orifice of a first size, a second orifice of a second size that is larger than the first size, and a mechanism that automatically moves the first orifice between a first position and a second position. When the first orifice is in the first position, the flow of gas passes through both the first orifice and second orifice. When the first orifice is in the second position, the flow of gas bypasses the first orifice and flows through the second orifice with a specific flow rate or a second pressure that is less than the first pressure. The apparatus may also include a gauge that provides a visual indication of both the specific flow rate and the second pressure.

Abstract: An apparatus comprises a horizontal array of emitter/detector pairs; an array of lens pairs mounted above and aligned with emitter/detector pairs; and a first curved reflective surface positioned such that for each emitter/detector pair and corresponding lens pair, light from the emitter that passes through a lens of the lens pair is redirected into the far field, and light arriving from the far field is redirected through the other lens of the lens pair onto the detector. Light from each emitter is emitted upwards along a vertical axis, and light received by each detector is incident on the detector downwards along a vertical axis. If light emitted from the first array and reflected by the first surface into the far field reflects off an object in the far field and returns to the apparatus, the returning light is reflected off the first surface and detected by the first array.

Abstract: A tissue embedder comprising a transport mechanism for an input member, the input member adapted to hold a plurality of tissue supports, with each tissue support associated with a mould, a wax bath and a cooling station wherein the transport mechanism moves the input member from a wax bath to a cooling station.

Abstract: Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(?O)—R6, —C(?O)—O—R7, or —C(?O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH?CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

Abstract: Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(?O)—R6, —C(?O)—O—R7, or —C(?O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH?CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

Abstract: An apparatus for micromanipulation of biological material, said apparatus including a vessel 1 having a reservoir 2 wherein said vessel has a channel 3 formed in a portion of said reservoir, said channel including an intermediate restriction 4 dimensioned to resist passage of said biological material but allow passage of liquid treatment solutions.

Abstract: Disclosed are systems and methods for predicting demographics about authors of social media. A dataset relates features from social media messages to known demographic information about authors of the social media messages. The social media messages and known demographics may be retrieved from different social media services. Adjustable weights are associated with alternative demographic values for the features. The dataset is used to predict unknown demographics of users based on the adjustable weights associated with the alternative demographic values for extracted features from social media messages. A confidence level may be output for a predicted demographic that corresponds to a difference between a sum of weights associated with the predicted value and another demographic value. The predicted demographic value may be output when the confidence level exceeds a threshold. The weights may be updated when the confidence level is below the threshold even when the prediction is correct.

Abstract: An apparatus for micromanipulation of biological material, includes a vessel (1) having a reservoir (2) wherein the vessel has a channel (3) formed in a portion of the reservoir, the channel including an intermediate restriction (4) dimensioned to resist passage of the biological material but allow passage of liquid treatment solutions.

Abstract: Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(?O)—R6, —C(?O)—O—R7, or —C(?O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH?CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

Abstract: Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(?O)—R6, —C(?O)—O—R7, or —C(?O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH?CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

Abstract: A tissue handling apparatus is provided comprising a support and a locator, for processing and embedding tissue samples. The support and cover form a chamber, within which a tissue sample is oriented prior to processing. After processing, the tissue sample within the chamber is embedded and the locator is removed, leaving the tissue sample correctly oriented in embedding material, mounted to a support, ready for microtoming.

Abstract: Disclosed are systems and methods for predicting demographics about authors of social media. A dataset relates features from social media messages to known demographic information about authors of the social media messages. The social media messages and known demographics may be retrieved from different social media services. Adjustable weights are associated with alternative demographic values for the features. The dataset is used to predict unknown demographics of users based on the adjustable weights associated with the alternative demographic values for extracted features from social media messages. A confidence level may be output for a predicted demographic that corresponds to a difference between a sum of weights associated with the predicted value and another demographic value. The predicted demographic value may be output when the confidence level exceeds a threshold. The weights may be updated when the confidence level is below the threshold even when the prediction is correct.

Abstract: A method of operator competency management includes providing a computing system having a processor running a software application. The software application implements an Operator Competency Model (OCM) which includes a simulated competency exercise including a plurality of simulated tasks for an operator in a processing facility running a physical process, wherein a competency for each simulated task is mapped to an assessment tool, wherein the assessment tools collectively include at least one subjective assessment tool and at least one automatically generated assessment tool. Responsive to the operator performing the simulated competency exercise, the performance of the operator is evaluated using respective ones of the assessment tools for the simulated tasks to generate competency data for the operator.

Abstract: Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5 is H, optionally substituted alkyl, optionally substituted heterocycle, —C(?O)—R6, —C(?O)—O—R7, or —C(?O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH?CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

Abstract: Substituted pyridoindoles for incorporation in pharmaceutical compositions employed in the treatment of various diseases correspond to formula (I) wherein R1 is H or optionally substituted alkyl; R2, R3, R4 are each independently selected from H, —O-alkyl, —S-alkyl, alkyl, halo, —CF3, and —CN; G is —CR12R13—NR5— or —NR5—CR12R13; R5; is H, optionally substituted alkyl, optionally substituted heterocycle, —C(?O)—R6, —C(?O)—O—R7, or —C(?O)—NR19R20; R6 and R7 are each optionally substituted alkyl or optionally substituted heterocycle; R8, R9, R10, R11, R12, R13, R19 and R20 are each independently selected from H or optionally substituted alkyl; R14 and R15 are each independently H or halogen; L is —CH2—O—, —CH2CH2—, —CH?CH— or a bond; and B is aryl or heteroaryl or cycloalkyl; with the proviso that, when L is a direct bond, B cannot be unsubstituted heteroaryl or heteroaryl monosubstituted with fluorine.

Abstract: An apparatus and method for providing a work surface proximate to a seat in a vehicle. The apparatus comprises a base support connectable to the vehicle, a substantially planar member and a parallel linkage extending between the base support and the planar member for planar translational movement from a first position to a second position about an arcuate path defining a first plane. The first position is substantially proximate to the seat and the second position is above the seat and forward of the first position. The planar member is also pivotable about an axis parallel to the first plane away from the seat. The apparatus further comprises a support for selectably maintaining the planar member at a substantially horizontal orientation. The method comprises moving the planar member from the first position to the second position, rotating the planar member to the horizontal orientation and supporting the planar member with the support.

Abstract: Novel MCH-1 receptor antagonists are disclosed. These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.

Abstract: MCH-1 receptor antagonists are disclosed having the general formula These compounds are used in the treatment of various disorders, including obesity, anxiety, depression, non-alcoholic fatty liver disease, and psychiatric disorders. Methods of making these compounds are also described in the present invention.