Patents by Inventor John A. Hossack

John A. Hossack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10507315
    Abstract: A catheter system including an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion of a length of the elongate tubular member. The distal end portion of the elongate member is dimensioned and adapted to advance to or in proximity to a treatment site of a subject. A microbubble device is in fluid communication with the lumen. The microbubble device includes at least one input port for receiving a flow of material into the device and an output port configured to output microbubbles from the microbubble device. A second tubular member is in fluid communication with one of the at least one input ports. A pressure fitting arrangement is adapted to maintain a seal between the second tubular member and the input port.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: December 17, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: John A. Hossack, Brian R. Wamhoff, Alexander L. Klibanov, Johnny Chen, Brent A. French
  • Publication number: 20190336792
    Abstract: Apparatus or techniques can include an applicator that can include an expandable element and an ultrasonic transducer. The applicator can be inserted into a cavity of a tissue region of a patient and images of the cavity and the applicator can be generated based on signals obtained from the ultrasonic transducer. Dosing of radiation can be determined based on the images and a dose of radiation can be delivered to the tissue region by a radiation source located in the applicator.
    Type: Application
    Filed: May 2, 2019
    Publication date: November 7, 2019
    Inventors: David R. Brenin, Timothy Norman Showalter, John A. Hossack
  • Patent number: 10401327
    Abstract: A reflection-mode multispectral photoacoustic microscopy (PAM) system and related method is disclosed, based on an optical-acoustic objective in communication with an ultrasonic transducer. In some embodiments of the disclosed technology, when aligned and positioned in a predetermined manner, little to no chromatic aberration is provided, and with convenient confocal alignment of the optical excitation and acoustic detection.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: September 3, 2019
    Assignee: UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Song Hu, Rui Cao, John A. Hossack, Joseph P. Kilroy
  • Patent number: 10368834
    Abstract: An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4?2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about ½?, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.
    Type: Grant
    Filed: April 25, 2012
    Date of Patent: August 6, 2019
    Assignee: University of Virginia Patent Foundation
    Inventors: F. William Mauldin, Jr., John A. Hossack, Kevin Owen
  • Publication number: 20190083817
    Abstract: Disclosed are methods, systems, and non-transitory computer readable media having stored thereon executable instructions that when executed by the processor of a computer control the computer to perform therapeutic ultrasound, such for the treatment of Ischemic reperfusion injury (IRI). The methods, systems, and non-transitory computer readable media can involve steps comprising: imaging a target tissue region within said subject, such as wherein the target tissue region comprises spleen tissue; identifying a volume region of interest (ROI) in said target tissue; and applying ultrasonic energy to the ROI, wherein applying the ultrasonic energy comprises emitting a sequence of ultrasonic pulses from an ultrasound transducer, the sequence of ultrasound pulses having predetermined frequency, mechanical index, pulse lengths, and pulse spacings, while performing a volumetric sweep through the ROI systematically for a selected total time duration, such as between about 3 minutes and about 15 minutes.
    Type: Application
    Filed: May 3, 2017
    Publication date: March 21, 2019
    Inventors: Mark D. Okusa, Joseph C. Gigliotti, John A. Hossack
  • Publication number: 20180214130
    Abstract: Aspects of various examples described herein can include using a wearable ultrasound device (e.g., a device wearable or manipulated using a fingertip). The wearable ultrasound device can include an ultrasound transducer element array, and can have a housing providing circuitry to process signals to or from the array, such as digitizing such signals. For example, a channel count of the analog signal channels corresponding to individual sensors in the array can be converted to a single digital channel (e.g., a serial channel), or at least a reduced channel count as compared to a count of transducer elements. In this manner, a wired or wireless coupling between the ultrasound “front end” circuitry in the wearable device and processing or display hardware elsewhere need not accommodate a large number of analog channels, and can instead, for example, have a digital communication interface.
    Type: Application
    Filed: July 28, 2016
    Publication date: August 2, 2018
    Inventors: John A. Hossack, Gorav Ailawadi
  • Patent number: 9989497
    Abstract: Pulse-echo imaging systems and methods are provided, including a transmit code sequencer and a pulse generation circuit, The transmit code sequencer is configured to input a transmit code sequence to the pulse generation circuit. A transducer is configured to receive electrical signals provided as pulses using coded excitation according to the transmit code sequence, and to transduce the electrical signals to pulses of energy other than electrical signals. The transducer is further configured to receive echoes of the pulses of energy other than electrical signals and convert the echoes to received electrical signals generate using coded excitation. A receive circuit is configured to receive the received electrical signals generate using coded excitation, perform analog sampling of the received electrical signals generate using coded excitation, and provide a weighted, summed digital signal by processing the analog samples.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: June 5, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: William F. Walker, Michael I. Fuller, Karthik Ranganathan, John A. Hossack, Travis N. Blalock
  • Patent number: 9960019
    Abstract: The present invention generally relates to a ring assembly that may be used in an etching or other plasma processing chamber. The ring assembly generally includes an inner ring body having a top planar surface and a bottom planar surface, and an outer ring body having a top surface, a bottom surface substantially parallel to the top surface, and an inside surface that extends between the top surface and the bottom surface, the inside surface having a roof covering a portion of the inner ring body when the inner ring body is disposed adjacent the roof, wherein the inner ring body can be flipped into a different position so that a portion of the inner ring body that is not covered by the roof provides a substantially planar surface.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: May 1, 2018
    Assignee: Applied Materials, Inc.
    Inventors: Sandhya Arun, Prashanth Kodigepalli, Padma Gopalakrishnan, Ashish Bhatnagar, Dan Martin, Christopher Heath John Hossack
  • Patent number: 9949722
    Abstract: An ultrasound system and method that can include: a receive beamformer configured to receive signals from a transducer; a processor coupled to the receive beamformer, the processor configured to: analyze echo data reflected from a region of interest, the echo data elicited by a transmitted pulse sequence; using the echo data, determine a central tendency of a signal magnitude from regions of adherent microbubbles over time within the region of interest; determine a time series of the signal magnitude; using the time series, determine an initial signal magnitude parameter; obtain a saturated signal parameter and a residual signal parameter using the time series; and determine a relative indication of information indicative of the residual signal magnitude versus the saturated signal magnitude.
    Type: Grant
    Filed: December 3, 2014
    Date of Patent: April 24, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: F. William Mauldin, Jr., Shiying Wang, John A. Hossack, Alexander L. Klibanov
  • Publication number: 20180099059
    Abstract: A composition for cell tracking and molecular imaging containing perfluorocarbon (“PFC”) droplets having a liquid PFC core enclosed within a stabilizing shell and embedded with solid nanoparticles. The solid nanoparticles act as nucleating agents for reducing the activation pressure of the liquid PFC core required to transition the liquid PFC core to a gaseous microbubble thereby permitting the use of more body-temperature stable longer chain PFCs in the liquid PFC core. The improved stability of the PFC droplets with a reduced or limited increase in the activation pressure required due to the nucleating nanoparticles improves the efficacy of using the PFC droplets as phase-change contrast agents.
    Type: Application
    Filed: October 10, 2017
    Publication date: April 12, 2018
    Inventors: John A. Hossack, Adam Joseph Dixon, Edwin Lu
  • Patent number: 9924923
    Abstract: Ultrasound apparatus or techniques can include obtaining reflected ultrasound echo information, which can be used to construct a two-dimensional or three-dimensional representation of an at least approximately specular reflected target, such as bone. In an example, echo information can be obtained from spatially-overlapping tissue regions, such as using one or more of an array of ultrasonic transducers, or mechanically-scanning one or more ultrasonic transducers. In an example, one or more of a deformable housing or a deformable coupling pad can be used, such as to couple ultrasonic energy between one or more transducers and a tissue region.
    Type: Grant
    Filed: June 13, 2013
    Date of Patent: March 27, 2018
    Assignee: University of Virginia Patent Foundation
    Inventors: F. William Mauldin, Jr., John A. Hossack, Kevin Owen
  • Publication number: 20180035979
    Abstract: An apparatus can be used to generate acoustic imaging pulse sequences and receive corresponding echoes elicited by the acoustic imaging pulse sequences. An acoustic radiation force (ARF) pulse sequence can be generated to agitate a contrast medium in a tissue region between the acoustic imaging pulse sequences. A decorrelation between images corresponding to the received echoes can be determined. A weighting map can be applied to an image to weight a region of the image corresponding to a spatial location of the contrast medium using the determined decorrelation. In an example, the receiving of corresponding echoes elicited by the acoustic imaging pulse sequences can include receiving acoustic energy having a range of frequencies offset from a fundamental frequency associated with the acoustic imaging pulse sequences. An acoustic imaging pulse sequence can include a pulse having an inverted amplitude envelope with respect to another pulse included in the sequence.
    Type: Application
    Filed: August 3, 2017
    Publication date: February 8, 2018
    Inventors: Elizabeth Bronwyn Herbst, John A. Hossack, Shiying Wang, F. William Mauldin, JR.
  • Publication number: 20170356884
    Abstract: A reflection-mode multispectral photoacoustic microscopy (PAM) system and related method is disclosed, based on an optical-acoustic objective in communication with an ultrasonic transducer. In some embodiments of the disclosed technology, when aligned and positioned in a predetermined manner, little to no chromatic aberration is provided, and with convenient confocal alignment of the optical excitation and acoustic detection.
    Type: Application
    Filed: December 8, 2015
    Publication date: December 14, 2017
    Inventors: Song HU, Rui CAO, John A. HOSSACK, Joseph P. KILROY
  • Publication number: 20170196534
    Abstract: A medical imaging apparatus, such as including a processor circuit, can be used to construct a first image of a plane parallel to the surface of an ultrasonic imaging transducer, the plane corresponding to a locus at a specified depth within a first region of tissue. The apparatus can obtain information about a location of a vessel in the first image, then obtain, from a second region of tissue, imaging information corresponding to loci in planes parallel to the surface of the transducer, the planes at depths automatically determined at least in part using the obtained information about the location of the vessel in the first image. In an example, the apparatus can automatically determine an adjusted depth corresponding to the location of the vessel in the second region, and construct a second image of a plane corresponding to the adjusted depth within the tissue.
    Type: Application
    Filed: September 19, 2016
    Publication date: July 13, 2017
    Inventors: John A. Hossack, Michael I. Fuller, Travis N. Blalock
  • Publication number: 20170000458
    Abstract: In some illustrative embodiments, an incoming signal from a transducer in an ultrasound imaging beam-former apparatus is applied to an in-phase sample-and-hold and a quadrature sample-and-hold. The quadrature sample-and-hold may be clocked a quarter period behind the in-phase sample-and-hold. The output of the sample-and-holds are applied to in-phase and quadrature analog-to-digital converters. A magnitude calculator receives the in-phase and quadrature digital values, and outputs a magnitude. A phase calculator receives the in-phase and quadrature digital values, and outputs a phase. An apodizer applies a difference between an amplitude of the outgoing signal and the magnitude and applies a first illumination to a image point in substantial proportion to the difference, and a phase rotator applies a second illumination to the image point in substantial proportion to the phase.
    Type: Application
    Filed: February 29, 2016
    Publication date: January 5, 2017
    Inventors: Travis N. Blalock, William F. Walker, John A. Hossack
  • Patent number: 9526922
    Abstract: A method and related system for providing therapy to a treatment site, such as stenosis or other vasculature disease, at one or more locations of a subject, such as the vasculature. The method includes: advancing an ultrasound catheter to or in proximity to the subject's treatment site; infusing microbubbles into or proximal to the treatment site; and delivering ultrasonic energy from the ultrasound catheter. The ultrasonic energy may be adapted for: imaging the treatment site, translating the microbubbles into or in the vicinity of the treatment site and/or rupturing the microbubbles.
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: December 27, 2016
    Assignee: University of Virginia Patent Foundation
    Inventors: John A. Hossack, Brian R. Wamhoff, Alexander L. Klibanov
  • Patent number: 9445780
    Abstract: A medical imaging apparatus, such as including a processor circuit, can be used to construct a first image of a plane parallel to the surface of an ultrasonic imaging transducer, the plane corresponding to a locus at a specified depth within a first region of tissue. The apparatus can obtain information about a location of a vessel in the first image, then obtain, from a second region of tissue, imaging information corresponding to loci in planes parallel to the surface of the transducer, the planes at depths automatically determined at least in part using the obtained information about the location of the vessel in the first image. In an example, the apparatus can automatically determine an adjusted depth corresponding to the location of the vessel in the second region, and construct a second image of a plane corresponding to the adjusted depth within the tissue.
    Type: Grant
    Filed: December 4, 2010
    Date of Patent: September 20, 2016
    Assignee: University of Virginia Patent Foundation
    Inventors: John A. Hossack, Michael I. Fuller, Travis N. Blalock
  • Publication number: 20160206867
    Abstract: A catheter system including an elongate tubular member having a proximal end portion, a distal end portion and a lumen extending through at least a portion of a length of the elongate tubular member. The distal end portion of the elongate member is dimensioned and adapted to advance to or in proximity to a treatment site of a subject. A microbubble device is in fluid communication with the lumen. The microbubble device includes at least one input port for receiving a flow of material into the device and an output port configured to output microbubbles from the microbubble device. A second tubular member is in fluid communication with one of the at least one input ports. A pressure fitting arrangement is adapted to maintain a seal between the second tubular member and the input port.
    Type: Application
    Filed: December 9, 2015
    Publication date: July 21, 2016
    Inventors: John A. Hossack, Brian R. Wamhoff, Alexander L. Klibanov, Johnny Chen, Brent A. French
  • Patent number: 9275630
    Abstract: In some illustrative embodiments, an incoming signal from a transducer in an ultrasound imaging beam-former apparatus is applied to an in-phase sample-and-hold and a quadrature sample-and-hold. The quadrature sample-and-hold may be clocked a quarter period behind the in-phase sample-and-hold. The output of the sample-and-holds are applied to in-phase and quadrature analog-to-digital converters. A magnitude calculator receives the in-phase and quadrature digital values, and outputs a magnitude. A phase calculator receives the in-phase and quadrature digital values, and outputs a phase. An apodizer applies a difference between an amplitude of the outgoing signal and the magnitude and applies a first illumination to a image point in substantial proportion to the difference, and a phase rotator applies a second illumination to the image point in substantial proportion to the phase.
    Type: Grant
    Filed: August 16, 2011
    Date of Patent: March 1, 2016
    Assignee: University of Virginia Patent Foundation
    Inventors: Travis N Blalock, William F Walker, John A Hossack
  • Patent number: 9244160
    Abstract: In some illustrative embodiments, an ultrasonic transducer drive includes a signal generator for producing an outgoing signal and a transducer for converting the outgoing signal to outgoing ultrasound. The transducer may also convert at least a portion of ultrasound reflected by an object to an incoming signal. The transducer may have a transmit side connected conductably to the signal generator during at least a first predetermined period of time and a receive side connected conductably to a signal receiver during at least a second predetermined period of time. A shunt may be connectable between the receive side and a reference potential. The signal generator may generate the outgoing signal during at least substantially the first predetermined period of time while the shunt connects the receive side to the reference potential. The signal receiver may receive the incoming signal during substantially the second predetermined period of time while the shunt is substantially open.
    Type: Grant
    Filed: July 14, 2005
    Date of Patent: January 26, 2016
    Assignee: University of Virginia Patent Foundation
    Inventors: Travis N. Blalock, William F. Walker, John A. Hossack