Patents by Inventor John A. Howe

John A. Howe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cell lines for production of replication-defective adenovirus
    Patent number: 7851218
    Abstract: The present invention provides cell lines for the production of E1-deleted adenovirus (rAd) vectors that complement E1A and E1B functions. The present invention also provides cell lines for the production of E1- and E2-deleted adenovirus vectors that complement E1A, E1B and E2B polymerase functions. The invention provides particular cell lines that complement E1A function by insertion of an E1A sequence containing mutations in the 243R and 289R proteins and an E1B sequence comprising the E1B-55K gene. Production yields in the resulting producer cell lines, designated SL0003 and SL0006, were similar to those obtained from 293 cells without generation of detectable recombinant replication competent adenovirus (“RCA”).
    Type: Grant
    Filed: December 12, 2005
    Date of Patent: December 14, 2010
    Assignee: Schering Corporation
    Inventors: John A. Howe, Ken N. Wills, Robert Orville Ralston, II, Scott Joseph Sherrill
  • HIV GENE CLONING STRATEGY
    Publication number: 20080220528
    Abstract: The invention relates to methods for cloning Human Immunodeficiency Virus (HIV) genes, in particular HIV envelope genes. The invention also relates to cloning strategies for mapping resistance determinants for HIV genes, in particular HIV envelope genes.
    Type: Application
    Filed: December 21, 2007
    Publication date: September 11, 2008
    Inventors: John A. Howe, Robert O. Ralston