Abstract: Some embodiments provide for an inspiratory limb for a breathing circuit that includes a first segment that comprises a first heater wire circuit and a second segment that comprises a second heater wire circuit. The inspiratory limb can include an intermediate connector that includes a connection circuit that electrically couples the first heater wire circuit to the second heater wire circuit. The inspiratory limb can be configured to operate in two modes wherein, in a first mode, electrical power passes through the first electrical connection to provide power to the first heater wire circuit without providing power to the second heater wire circuit, and in a second mode, electrical power pass through the first electrical connection to provide power to both the first heater wire circuit and the second heater wire circuit.

Abstract: The present disclosure relates to a fluid dispensing device (10), the fluid dispensing device (1) comprising: a housing (10) to accommodate a container (110) filled with a fluid, wherein the housing (10) comprises a sidewall 118) extending along a longitudinal direction (z), —an outlet orifice (3), —a discharge mechanism (130) operable for spray discharging at least one or multiple doses of the fluid via the outlet orifice (3), —a protective cap (12) pivotally supported on or by the housing (10) between an open position and a closed position, wherein when in the closed position the outlet orifice (3) is effectively covered by the protective cap (12), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a biasing mechanism (150) comprising a biasing member (160) operationally coupled to the prote

Abstract: The present disclosure relates to a fluid dispensing device (1) comprising: —a housing (10) to accommodate a container (110) filled a fluid, —a outlet orifice (3), —a discharge mechanism (130) operable for spray discharging multiple doses of the fluid via the outlet orifice (3), —a mechanical energy storage (50) coupled to the discharge mechanism (130), reversibly transferable between a preloaded state and an unloaded state and configured to store mechanical energy in the preloaded state effective to produce the spray discharging of the fluid, —a releasable interlock (70) configured to retain the mechanical energy storage (50) in the preloaded state, —a trigger mechanism (90) operationally engageable with the interlock (70) and operable i) to release a first portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a first time and ii) to release at least a second portion of the mechanical energy stored in the mechanical energy storage (50) when actuated for a second time

Abstract: The present disclosure relates to a mechanical energy storage for a fluid dispensing device (10), the mechanical energy storage comprising:—a first drive spring (51) extending along a longitudinal direction (z),—the drive spring (51) comprising a first longitudinal end (53) to engage with a housing (10) of the fluid dispensing device (1) and a second longitudinal end (54) opposite to the first longitudinal end (53) to engage with a driver (30) movable relative to the housing (10) along the longitudinal direction (z),—wherein the mechanical energy storage (50) is reversibly transferable into a pre-loaded state by resiliently compressing the first drive spring (51) in the longitudinal direction (z) to thereby induce a resilient deformation of the first drive spring (51) in a first direction (y) transverse to the longitudinal direction (z), and-wherein the mechanical energy storage (50) is transferable from the pre-loaded state into an unloaded state by allowing the first drive spring (51) to relax into or towar

Abstract: The invention relates to administration at particular dosages of a compound which is a substituted 2-oxo-1-pyrrolidinyl triazole of formula (I) or an isomer or a pharmaceutically acceptable salt thereof.

Abstract: Improved computer modeling techniques, and uses thereof, are described herein. A set of unstructured textual data is received. Certain textual data is removed from the set of unstructured data to form an initial vocabulary set of textual data. One or more bigrams are added to the vocabulary set of textual data to form a final vocabulary set of textual data. The final vocabulary set of textual data is divided into a plurality of subsets of textual data based on type. A model is trained using each of the plurality of subsets of textual data to form a plurality of trained models, each corresponding to one of the types.

Abstract: A sectional inner liner of a pressure vessel comprising the sectional inner liner and an outer layer disposed around the sectional inner liner, the sectional inner liner comprising: at least two inner liner sections, wherein each inner liner section comprises an internal network structure; and at least two cap sections, wherein, the at least two cap sections and at least two inner liner sections are configured to assemble into a sectional inner liner.

Abstract: The shower system has a heat exchanger located in compartment vertically adjacent to the wall of the shower space and closed off by an openable or removable panel. The heat exchanger comprising a helically winding heat exchange conduit with successive windings around a vertical axis in said compartment above the floor of the shower space. A pump coupled to the shower drain pumps warm water to a warm water feed of the heat exchanger, from where it is sprayed on a top winding of the heat exchange conduit. Tap water is fed to the shower head successively via the heat exchange conduit and a heater and/or a mixing element for mixing water from the heat exchanger with water from a supply input for external hot water.

Abstract: The shower system has a heat exchanger located in compartment vertically adjacent to the wall of the shower space and closed off by an openable or removable panel. The heat exchanger comprising a helically winding heat exchange conduit with successive windings around a vertical axis in said compartment above the floor of the shower space. A pump coupled to the shower drain pumps warm water to a warm water feed of the heat exchanger, from where it is sprayed on a top winding of the heat exchange conduit. Tap water is fed to the shower head successively via the heat exchange conduit and a heater and/or a mixing element for mixing water from the heat exchanger with water from a supply input for external hot water.

Abstract: Improved computer modeling techniques, and uses thereof, are described herein. A set of unstructured textual data is received. Certain textual data is removed from the set of unstructured data to form an initial vocabulary set of textual data. One or more bigrams are added to the vocabulary set of textual data to form a final vocabulary set of textual data. The final vocabulary set of textual data is divided into a plurality of subsets of textual data based on type. A model is trained using each of the plurality of subsets of textual data to form a plurality of trained models, each corresponding to one of the types.

Abstract: The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

Abstract: The present invention pertains generally to the field of chemical synthesis, and more particularly to methods of chemical synthesis which include the step of preparing a substituted 10H-phenothiazine-3,7-diamine compound of Formula (1) by a step of selective alkylation by reductive amination, in which the corresponding unsubstituted diamine of Formula (4) is reacted with aldehyde/ketone, under reductive amination conditions. The present invention also relates to such methods which incorporate additional subsequent and/or preceding steps, for example, to prepare compounds of Formulae (2) and (3) from compounds of Formula (1), and to prepare compounds of Formula (4) from, for example, compounds of Formulae (5), (6), (7), (8), and (9). Compounds of Formula (1), Formula (2), and Formula (3) are useful, for example, in the treatment of diseases of protein aggregation, such as Alzheimer's disease.

Abstract: A shielded power feeder system may include at least one unshielded power feeder conductor, and at least one grounded guard wire conductor positioned adjacent to the at least one unshielded power feeder conductor, the at least one unshielded power feeder conductor and the at least one grounded guard wire forming a bundle.

Abstract: A shielded power feeder system may include at least one unshielded power feeder conductor having first and second ends, a neutral conductor positioned adjacent the power feeder conductor, the power feeder conductor and neutral conductor forming a bundle, and the neutral conductor having a grounded conductive shield.

Abstract: Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.

Abstract: A shielded power feeder system may include at least one unshielded power feeder conductor, and at least one grounded guard wire conductor positioned adjacent to the at least one unshielded power feeder conductor, the at least one unshielded power feeder conductor and the at least one grounded guard wire forming a bundle.

Abstract: Described are methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylhioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the method comprises the steps of, in order: a thiosulfonic acid formation (TSAF); an oxidative coupling (OC); and a ring closure (RC). Also described are resulting compounds and compositions comprising them (e.g., tablets, capsules) for use in methods of medical treatment and diagnosis, etc., for example, for tauopathies, or Alzheimer's disease (AD).

Abstract: This invention pertains generally to the field of chemical synthesis and purification, and more specifically to methods of synthesizing and purifying certain 3,7-diamino-phenothiazin-5-ium compounds (referred to herein as “diaminophenothiazinium compounds”) including Methylthioninium Chloride (MTC) (also known as Methylene Blue). In one embodiment, the e//i method comprises the steps of in order: a thiosulfonic acid formation (TSAF) as illustrated below, wherein the reaction is carried out in the presence of a thio sulfate and an oxidizing agent that is or comprises persulfate an oxidative coupling (OC); and a ring closure (RC). The resulting compounds and compositions comprising them (e.g., tablets, capsules) are useful in methods of medical treatment and diagnosis, etc., for example, tauopathies, or Alzheimer's disease (AD).

Abstract: Provided are certain benzothiazole, imidazothiazole, imidazopyrimidine and imidazopyridine compounds, including, for example: formula (I) and pharmaceutically and physiologically acceptable salts, hydrates, and solvates thereof. Such compounds can be used as diagnostic ligands or labels of tau protein and PHF.