Patents by Inventor John A. Kepler

John A. Kepler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Androstane and pregnane steroids with potent allosteric gaba receptor chloride ionophore modulating properties
    Patent number: 10087211
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 2, 2018
    Assignees: RESEARCH TRIANGLE INSTITUTE, THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
    Inventors: Scott P. Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20170051008
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: November 2, 2016
    Publication date: February 23, 2017
    Applicants: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Herman NAVARRO, Rafal KAMINSKI, Matthew ORR
  • Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
    Patent number: 9518080
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: August 23, 2013
    Date of Patent: December 13, 2016
    Assignees: RESEARCH TRIANGLE INSTITUTE, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Scott P Runyon, Michael Rogawski, Edgar Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20140094619
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: August 23, 2013
    Publication date: April 3, 2014
    Applicants: US GOV BY THE SEC. OF DEPT. OF HEALTH & HUMAN SERV, RESEARCH TRIANGLE INSTITUTE
    Inventors: Scott P. RUNYON, Michael ROGAWSKI, Edgar COOK, John KEPLER, Hernan NAVARRO, Rafal KAMINSKI, Matthew ORR
  • Androstane and pregnane steroids with potent allosteric GABA receptor chloride ionophore modulating properties
    Patent number: 8575375
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Grant
    Filed: June 16, 2008
    Date of Patent: November 5, 2013
    Assignees: Research Triangle Institute, The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: Scott P. Runyon, Michael A. Rogawski, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr, Kevin M. Cook
  • ANDROSTANE AND PREGNANE STEROIDS WITH POTENT ALLOSTERIC GABA RECEPTOR CHLORIDE IONOPHORE MODULATING PROPERTIES
    Publication number: 20110092473
    Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.
    Type: Application
    Filed: June 16, 2008
    Publication date: April 21, 2011
    Applicants: Research Triangle Institute, US GOV BY THE SEC. OF DEPT. OF HEALTH & HUMAN SERV.
    Inventors: Scott P. Runyon, Michael Rogawski, Edgar Cook, Kevin M. Cook, John Kepler, Hernan Navarro, Rafal Kaminski, Matthew Orr
  • Storing and handling liquid reagents
    Patent number: 7753095
    Abstract: A liquid storage apparatus provides a safe and easy to use device for efficiently managing liquid reagents used in a variety of laboratory equipment. The liquid storage apparatus helps reduce the likelihood of accidental sticks to laboratory personnel, allows for flexibility of experimental design, and helps maximize the use of chemical regents to prevent waste. The apparatus includes a plurality of containers of liquid with a pierceable septum interface at each end. The apparatus also includes a lower array of needles with each of the lower needles in the lower array of needles arranged to penetrate the bottom pierceable septum of a different one of the containers. Each of the needles includes a passage so the liquid can flow out of the pierced container. The apparatus further includes an upper array of needles with each of the upper needles in the upper array of needles arranged to penetrate the top pierceable septum of a different one of the containers.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: July 13, 2010
    Assignee: Helicos Biosciences Corporation
    Inventors: Sepehr Kiani, John Kepler
  • Resist trim process to define small openings in dielectric layers
    Patent number: 7737021
    Abstract: The present invention is directed to a method of forming semiconductor devices. In one illustrative embodiment, the method comprises defining a photoresist feature having a first size in a layer of photoresist that is formed above a layer of dielectric material. The method further comprises reducing the first size of the photoresist feature to produce a reduced size photoresist feature, forming an opening in the layer of dielectric material under the reduced size photoresist feature, and forming a conductive material in the opening in the layer of dielectric material.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: June 15, 2010
    Assignee: Globalfoundries Inc.
    Inventors: Srikanteswara Dakshina-Murthy, Paul R. Besser, Jonathan B. Smith, Eric M. Apelgren, Christian Zistl, Jeremy I. Martin, Lie Larry Zhao, Nicholas John Kepler
  • METHODS AND DEVICES FOR BUBBLE MITIGATION
    Publication number: 20090249949
    Abstract: The invention relates to methods, systems and devices for mitigation of bubbles in a micro-fluidic environment. For example, the invention relates to methods, systems and devices for mitigation of bubbles from reagents, solvents, formulations and for improving chemical reactions in micro-fluidic systems, such as for fluorescence detection and polynucleotide sequencing.
    Type: Application
    Filed: March 4, 2009
    Publication date: October 8, 2009
    Applicant: Helicos BioSciences Corporation
    Inventors: John Kepler, Alexander Watson
  • Liquid Handling System and Methods for Mixing and Delivering Liquid Reagents
    Publication number: 20090246085
    Abstract: A liquid storage apparatus provides a safe and easy to use device for efficiently managing liquid reagents used in a variety of laboratory equipment. The liquid storage apparatus helps reduce the likelihood of accidents, allows for flexibility of experimental design, and helps maximize the use of chemical regents to prevent waste. The apparatus includes a plurality of containers with a pierceable septum interface at each end. The apparatus also includes a lower array of needles with each of the lower needles in the lower array of needles arranged to penetrate the bottom pierceable septum of a different one of the containers. The apparatus further includes a piercing device arranged to penetrate the top pierceable septum of a different one of the containers. Each of the piercing devices include a passageway so gas can flow into the pierced container.
    Type: Application
    Filed: March 31, 2008
    Publication date: October 1, 2009
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Alexander Watson, John Price, Parris Wellamn, John Kepler
  • Methods for Reducing Contaminants in Nucleic Acid Sequencing by Synthesis
    Publication number: 20090226900
    Abstract: The disclosure provides methods that improve fidelity of the sequencing-by-synthesis reactions, including methods that reduce impurities and contamination in various reagents, reaction mixtures, and other components of the sequencing systems.
    Type: Application
    Filed: March 5, 2008
    Publication date: September 10, 2009
    Applicant: HELICOS BIOSCIENCES CORPORATION
    Inventors: Hazen Babcock, Mirna Jarosz, Jennifer Colonell, Parris Wellman, Geoff Lowman, Jayson Bowers, John Kepler
  • Storing and handling liquid reagents
    Publication number: 20080142113
    Abstract: A liquid storage apparatus provides a safe and easy to use device for efficiently managing liquid reagents used in a variety of laboratory equipment. The liquid storage apparatus helps reduce the likelihood of accidental sticks to laboratory personnel, allows for flexibility of experimental design, and helps maximize the use of chemical regents to prevent waste. The apparatus includes a plurality of containers of liquid with a pierceable septum interface at each end. The apparatus also includes a lower array of needles with each of the lower needles in the lower array of needles arranged to penetrate the bottom pierceable septum of a different one of the containers. Each of the needles includes a passage so the liquid can flow out of the pierced container. The apparatus further includes an upper array of needles with each of the upper needles in the upper array of needles arranged to penetrate the top pierceable septum of a different one of the containers.
    Type: Application
    Filed: December 15, 2006
    Publication date: June 19, 2008
    Inventors: Sepehr Kiani, John Kepler
  • 17?-amino and hydroxylamino-11 ?-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 7018991
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: July 2, 2003
    Date of Patent: March 28, 2006
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6864248
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: November 4, 2003
    Date of Patent: March 8, 2005
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17&bgr;-acyl-17&agr;-propynyl-11&bgr;-(cyclic amino) aryl steroids and their derivatives having antagonist hormonal properties
    Patent number: 6740645
    Abstract: The invention is directed to a novel class of 17&bgr;-acyl-17&agr;-propynyl steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: September 3, 1999
    Date of Patent: May 25, 2004
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Jill M. O'Reilly
  • Androgenic steroid compounds and a method of making and using the same
    Publication number: 20040097477
    Abstract: An androgenic steroid compound of the formula: 1
    Type: Application
    Filed: November 4, 2003
    Publication date: May 20, 2004
    Applicant: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17 Beta-amino and hydroxylamino-11 beta-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Publication number: 20040023936
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Application
    Filed: July 2, 2003
    Publication date: February 5, 2004
    Applicant: RESEARCHTRIANGLE INSTITUTE
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Androgenic steroid compounds and a method of making and using the same
    Patent number: 6670352
    Abstract: An androgenic steroid compound of the formula: wherein: X, Y, Z, R1, R2, R3, R5 and R6 are as defined herein.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: December 30, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Yue-Wei Lee, Mansukh C. Wani
  • 17&bgr;-amino and hydroxylamino-11&bgr;-arylsteroids and their derivatives having agonist or antagonist hormonal properties
    Patent number: 6620801
    Abstract: The invention is directed to a novel class of steroids which exhibit potent antiprogestational activity.
    Type: Grant
    Filed: July 2, 2001
    Date of Patent: September 16, 2003
    Assignee: Research Triangle Institute
    Inventors: C. Edgar Cook, John A. Kepler, Gary S. Bartley, Rupa S. Shetty
  • Resist trim process to define small openings in dielectric layers
    Patent number: 6500755
    Abstract: The present invention is directed to a method of forming semiconductor devices. In one illustrative embodiment, the method comprises defining a photoresist feature having a first size in a layer of photoresist that is formed above a layer of dielectric material. The method further comprises reducing the first size of the photoresist feature to produce a reduced size photoresist feature, forming an opening in the layer of dielectric material under the reduced size photoresist feature, and forming a conductive material in the opening in the layer of dielectric material.
    Type: Grant
    Filed: December 6, 2000
    Date of Patent: December 31, 2002
    Assignee: Advanced Micro Devices, Inc.
    Inventors: Srikanteswara Dakshina-Murthy, Paul R. Besser, Jonathan B. Smith, Eric M. Apelgren, Christian Zistl, Jeremy I. Martin, Lie Larry Zhao, Nicholas John Kepler