Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS) useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Abstract: A method of determining that a subject electronic device 1021 . . . N is counterfeit. The method involves delivering the web page component to a subject device 1021 . . . N in response to a request. The web page component is adapted to retrieve actual values of a plurality of attributes from the subject device 1021 . . . N. Reference values of the plurality of attributes are retrieved from a device property store 110 and the method determined that the subject device 1021 . . . N is counterfeit when at least one of the actual values of the plurality of attributes is different to the reference value of that attribute.

Abstract: Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A method of preventing a subject communication device 1021 . . . N from accessing a resource when it is determined to be counterfeit. The method involves delivering the web page component to a subject communication device 1021 . . . N in response to a request. The web page component is adapted to retrieve actual values of a plurality of attributes from the subject communication device 1021 . . . N. Reference values of the plurality of attributes are retrieved from a device property store 110 and the method determines that the subject communication device 1021 . . . N is counterfeit when at least one of the actual values of the plurality of attributes is different to the reference value of that attribute.

Abstract: Finding care plan(s) matching desired aspects includes receiving a selection of a model care plan from a user; generating a feature hash vector representing the model care plan, resulting in a model feature hash vector; comparing feature hash vectors of existing care plans to the model feature hash vector to find care plan(s) best matching the desired aspect(s) of a user, resulting in best match(es); and providing one or more care plan recommendation(s) to the user based on the best match(es).

Abstract: Multifunctional molecules that include i) an antigen binding domain that binds to a calreticulin mutant protein; and one, two or all of: (ii) an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); (iii) a cytokine molecule or a modulator of a cytokine molecule; and/or (iv) a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A method for measuring furnace temperatures. The method includes obtaining radiance measurements from a plurality of regions of interest (ROIs) using a plurality of thermal imaging cameras, and measuring a surface temperature using a radiance measurement obtained from an ROI selected from the plurality of ROIs. Measuring the surface temperature includes determining an effective background radiance affecting the selected ROI using radiance measurements obtained from ROIs different from the selected ROI, obtaining a compensated radiance by removing the effective background radiance from the radiance measurement obtained from the selected ROI, and converting the compensated radiance to the measured surface temperature.

Abstract: Systems and methods are disclosed, and one includes determining a network resource state, based at least in part on a delay level of the network resource, determining a first priority user demand and a second priority user demand for the network resource, and upon the network resource state meeting a condition, adjusting an allocation of network resource bandwidth to the first priority user and an allocation of network resource bandwidth to the second priority user adjusting. The update of the allocation of network resource bandwidth to the first priority user is based at least in part on a combination of the first priority user demand, the second priority user demand, a first priority user guaranteed bandwidth, and a capacity of the network resource. The update of the allocation of network resource bandwidth to the second priority user is based at least in part on the adjusted allocation of network resource bandwidth to the first priority user.

Abstract: A method of switching from a first gateway within a plurality of first gateways to a second gateway in a network includes precaching configuration information on the second gateway, that is within the first gateways, prior to switch-over to the second gateway. The first gateway from which the second gateway is being switched is identified. The second gateway is configured in accordance with the configuration of the first gateway based on the precached configuration information prior to the switch-over to the second gateway. Data traffic from data applications using the network is replicated and sent to the first gateway and the second gateway. Bandwidths allocated to terminals in the network are frozen in association with the switch-over to the second gateway. The bandwidths allocated to the terminals in the network are unfrozen based at least in part on an indication of completion of the switch-over to the second gateway.

Abstract: The invention relates to inhibitors of glucosylceramide synthase (GCS), such as Compound of Formula I, shown below, as defined herein, useful for the treatment of metabolic diseases, such as lysosomal storage diseases, either alone or in combination with enzyme replacement therapy, cystic disease and for the treatment of cancer.

Abstract: A method of preventing a subject communication device 1021 . . . N from accessing a resource when it is determined to be counterfeit. The method involves delivering the web page component to a subject communication device 1021 . . . N in response to a request. The web page component is adapted to retrieve actual values of a plurality of attributes from the subject communication device 1021 . . . N. Reference values of the plurality of attributes are retrieved from a device property store 110 and the method determines that the subject communication device 1021 . . . N is counterfeit when at least one of the actual values of the plurality of attributes is different to the reference value of that attribute.

Abstract: An interface generator 6 generates a user interface for a mobile communication device 2 by providing, at step S2, a menu of functional components to a website owner 5 and receiving an indication of which of the functional components are selected for inclusion in the user interface from the website owner, at step S3. When the interface generator 6 receives a request for the user interface from the mobile communication device 2, at step S7, it delivers the user interface to the mobile communication device, at step S8, for display by the mobile communication device 2. The generated user interface includes the selected functional components and selection of a functional component included in the displayed user interface by a user of the mobile communication device 2 causes the mobile communication device 2 to carry out a task.

Abstract: A method of switching from a first gateway within a plurality of first gateways to a second gateway in a network includes precaching configuration information on the second gateway, that is within the first gateways, prior to switch-over to the second gateway. The first gateway from which the second gateway is being switched is identified. The second gateway is configured in accordance with the configuration of the first gateway based on the precached configuration information prior to the switch-over to the second gateway. Data traffic from data applications using the network is replicated and sent to the first gateway and the second gateway. Bandwidths allocated to terminals in the network are frozen in association with the switch-over to the second gateway. The bandwidths allocated to the terminals in the network are unfrozen based at least in part on an indication of completion of the switch-over to the second gateway.

Abstract: A method of switching from a first gateway within a plurality of first gateways to a second gateway in a network includes precaching configuration information on the second gateway, that is within the first gateways, prior to switch-over to the second gateway. The first gateway from which the second gateway is being switched is identified. The second gateway is configured in accordance with the configuration of the first gateway based on the precached configuration information prior to the switch-over to the second gateway. Data traffic from data applications using the network is replicated and sent to the first gateway and the second gateway. Bandwidths allocated to terminals in the network are frozen in association with the switch-over to the second gateway. The bandwidths allocated to the terminals in the network are unfrozen based at least in part on an indication of completion of the switch-over to the second gateway.

Abstract: Multispecific molecules that include a first tumor-targeting moiety; a second tumor-targeting moiety; and one, two or all of: an immune cell engager (e.g., chosen from an NK cell engager, a T cell engager, a B cell engager, a dendritic cell engager, or a macrophage cell engager); a cytokine molecule or a modulator of a cytokine molecule; and/or a stromal modifying moiety are disclosed. Additionally disclosed are nucleic acids encoding the same, methods of producing the aforesaid molecules, and methods of treating a cancer using the aforesaid molecules.

Abstract: A user interface system includes an extraction engine in communication with a managed infrastructure. The extraction engine in operation receives messages from the managed infrastructure and produces events that relate to the managed infrastructure and converts the events into words and subsets used to group the events into clusters that relate to failures or errors in the managed infrastructure includes managed infrastructure physical hardware. The managed infrastructure supports the flow and processing of information. A sigalizer engine includes one or more of an NMF engine, a k-means clustering engine and a topology proximity engine. The sigalizer engine determines one or more common steps from events and produces clusters relating to events. The sigalizer engine determines one or more common characteristics of events and produces clusters of events relating to the failure or errors in the managed infrastructure.

Abstract: A system for X-ray topography, the system includes a source assembly, a detector assembly, a filter and a processor. The source assembly is configured to direct at least an X-ray beam to impinge, at an angle, on a first surface of a sample, the X-ray beam is divergent when impinging on the first surface. The detector assembly is configured to detect the X-ray beam that had entered the sample at the first surface, diffracted while passing through the sample and exited the sample at a second surface that is opposite to the first surface, and to produce an electrical signal in response to the detected X-ray beam. The filter is mounted between the source assembly and the first surface, and is configured to attenuate an intensity of a selected spectral portion of the X-ray beam. The processor is configured to detect one or more defects in the sample based on the electrical signal.

Abstract: A method of preventing a subject communication device 1021 . . . N from accessing a resource when it is determined to be counterfeit. The method involves delivering the web page component to a subject communication device 1021 . . . N in response to a request. The web page component is adapted to retrieve actual values of a plurality of attributes from the subject communication device 1021 . . . N. Reference values of the plurality of attributes are retrieved from a device property store 110 and the method determines that the subject communication device 1021 . . . N is counterfeit when at least one of the actual values of the plurality of attributes is different to the reference value of that attribute.

Abstract: A payment system for a transaction between a user and a merchant includes establishing user account and merchant accounts with an mCreds processing agent, loading consumer credit into a consumer account of a user computing device associated with a permanent identifier, identifying a desired transaction by the user on a computer server; accessing a merchant account, authenticating the user by comparing a provided user credential provided by the user with the user credential present in the database, authenticating the user computing device by comparing a provided user device identifier with the permanent user device identifier present in the database, and processing a debit to the user mCreds account and a credit to the merchant mobile credit account.

Abstract: Finding care plan(s) matching desired aspects includes receiving a selection of a model care plan from a user; generating a feature hash vector representing the model care plan, resulting in a model feature hash vector; comparing feature hash vectors of existing care plans to the model feature hash vector to find care plan(s) best matching the desired aspect(s) of a user, resulting in best match(es); and providing one or more care plan recommendation(s) to the user based on the best match(es).